Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites

(2018) Björn D.M. Bean et al.   JOURNAL OF CELL BIOLOGY

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate

(2017) Weronika Rzepnikowska et al.   HUMAN MOLECULAR GENETICS

Vps13-Mcp1 interact at vacuole–mitochondria interfaces and bypass ER–mitochondria contact sites

(2017) Arun T. John Peter et al.   JOURNAL OF CELL BIOLOGY

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space

(2017) Sevan Mattie et al.   JOURNAL OF CELL BIOLOGY

The Vps13p–Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

(2017) Mithu De et al.   JOURNAL OF CELL BIOLOGY

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Piecing Together the Patchwork of Contact Sites

(2017) Alberto T. Gatta et al.   TRENDS IN CELL BIOLOGY

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation

(2017) Victoria Hung et al.   eLife

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

(2017) Jan J. Vonk et al.   PLoS One

Lithium Sensitive ORAI1 Expression, Store Operated Ca2+ Entry and Suicidal Death of Neurons in Chorea-Acanthocytosis

(2017) Lisann Pelzl et al.   Scientific Reports

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome

(2016) Sarah E. Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The physics of lipid droplet nucleation, growth and budding

(2016) Abdou Rachid Thiam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis

(2016) F. Lupo et al.   BLOOD

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells

(2016) Willi Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

(2016) Emily R. Eden et al.   DEVELOPMENTAL CELL

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites

(2016) Jae-Sook Park et al.   MOLECULAR BIOLOGY OF THE CELL

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis

(2016) Ri-Yao Yang et al.   PLoS One

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Chorein Sensitive Arrangement of Cytoskeletal Architecture

(2015) Sabina Honisch et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Diagnosis and Treatment of Chorea Syndromes

(2015) Andreas Hermann et al.   Current Neurology and Neuroscience Reports

Membrane contact sites, gateways for lipid homeostasis

(2015) Sujoy Lahiri et al.   CURRENT OPINION IN CELL BIOLOGY

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition

(2015) Nora Kory et al.   DEVELOPMENTAL CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering

(2015) O. Idevall-Hagren et al.   EMBO JOURNAL

ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

(2015) Alexander B. Lang et al.   JOURNAL OF CELL BIOLOGY

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA

(2014) Junfeng Bi et al.   Cell Metabolism

Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast

(2014) Stefan Böckler et al.   DEVELOPMENTAL CELL

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

(2014) J. M. Inloes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells

(2013) Ioana Alesutan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Chorein sensitivity of cytoskeletal organization and degranulation of platelets

(2013) Eva-Maria Schmidt et al.   FASEB JOURNAL

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER

(2013) F. Alpy et al.   JOURNAL OF CELL SCIENCE

The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage

(2013) K. Thiel et al.   JOURNAL OF CELL SCIENCE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis

(2012) Michael Föller et al.   FASEB JOURNAL

VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae

(2012) Jae-Sook Park et al.   JOURNAL OF CELL SCIENCE

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Vacuolar Protein Sorting Protein 13A, TtVPS13A, Localizes to the Tetrahymena thermophila Phagosome Membrane and Is Required for Efficient Phagocytosis

(2011) Haresha S. Samaranayake et al.   EUKARYOTIC CELL

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteome of Skeletal Muscle Lipid Droplet Reveals Association with Mitochondria and Apolipoprotein A-I

(2011) Huina Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reticulon Short Hairpin Transmembrane Domains Are Used to Shape ER Tubules

(2010) Nesia Zurek et al.   TRAFFIC

Promotion of Neurite Extension by Protrudin Requires Its Interaction with Vesicle-associated Membrane Protein-associated Protein

(2009) Shotaro Saita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Expanded mutational spectrum in Cohen syndrome, tissue expression, and transcript variants ofCOH1

(2008) Wenke Seifert et al.   HUMAN MUTATION

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY