Local structural unfolding at the edge-strands of beta sheets is the molecular basis for instability and aggregation of G85R and G93A mutants of superoxide dismutase 1

Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation

(2018) Debasish Kumar Ghosh et al.   BIOCHEMISTRY

Aggregation-prone Regions in HYPK Help It to Form Sequestration Complex for Toxic Protein Aggregates

(2018) Debasish Kumar Ghosh et al.   JOURNAL OF MOLECULAR BIOLOGY

Metastable states of HYPK-UBA domain's seeds drive the dynamics of its own aggregation

(2018) Debasish Kumar Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis

(2018) Ramu Manjula et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

(2017) Sanaz Rasouli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular dynamics of a far positioned SOD1 mutant V14M reveals pathogenic misfolding behavior

(2017) Dharma Rao Tompa et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Solvent sensitivity of protein aggregation in Cu, Zn superoxide dismutase: a molecular dynamics simulation study

(2017) Amresh Prakash et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Exploring the cause of aggregation and reduced Zn binding affinity by G85R mutation in SOD1 rendering amyotrophic lateral sclerosis

(2017) E. Srinivasan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Destabilization of the metal site as a hub for the pathogenic mechanism of five ALS-linked mutants of copper, zinc superoxide dismutase

(2016) Raúl Mera-Adasme et al.   Metallomics

Conformational Disorder of the Most Immature Cu, Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis

(2015) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures

(2015) Rafael Zambrano et al.   NUCLEIC ACIDS RESEARCH

SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis

(2015) Francesco Tafuri et al.   Frontiers in Cellular Neuroscience

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

(2015) Vladimir N. Uversky   Frontiers in Aging Neuroscience

SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology

(2014) Rosie K. A. Bunton-Stasyshyn et al.   NEUROSCIENTIST

Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations

(2014) M. C. Baxa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein charge ladders reveal that the net charge of ALS-linked superoxide dismutase can be different in sign and magnitude from predicted values

(2014) Yunhua Shi et al.   PROTEIN SCIENCE

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

(2013) Rachele A. Saccon et al.   BRAIN

Intrinsically Semi-disordered State and Its Role in Induced Folding and Protein Aggregation

(2013) Tuo Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

(2013) Yuewei Sheng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Study of mutation and misfolding of Cu-Zn SOD1 protein

(2013) S.P. Keerthana et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

(2013) Julie D. Atkin et al.   JOURNAL OF NEUROCHEMISTRY

Analyzing Effects of Naturally Occurring Missense Mutations

(2012) Zhe Zhang et al.   Computational and Mathematical Methods in Medicine

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Intrinsic disorder modulates protein self-assembly and aggregation

(2012) A. De Simone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Seeds of Neurodegeneration: Prion-like Spreading in ALS

(2011) Magdalini Polymenidou et al.   CELL

Intrinsically unstructured proteins and neurodegenerative diseases: Conformational promiscuity at its best

(2011) Samir Das et al.   IUBMB LIFE

Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport

(2010) Ping Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2Struc: the secondary structure server

(2010) D. P. Klose et al.   BIOINFORMATICS

Copper and Zinc Metallation Status of Copper-Zinc Superoxide Dismutase from Amyotrophic Lateral Sclerosis Transgenic Mice

(2010) Herman L. Lelie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New methods allowing the detection of protein aggregates

(2010) Barthélemy Demeule et al.   mAbs

A Role for Copper in the Toxicity of Zinc-Deficient Superoxide Dismutase to Motor Neurons in Amyotrophic Lateral Sclerosis

(2009) Kari A. Trumbull et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A

(2009) Ahmad Galaleldeen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The structural biochemistry of the superoxide dismutases

(2009) J.J.P. Perry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

(2009) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants

(2009) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Protein Folding Problem

(2008) Ken A. Dill et al.   Annual Review of Biophysics

Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis

(2008) Xiaohang Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization

(2008) Lucia Banci et al.   PLoS One