Structure-Activity Relationship in TLR4 Mutations: Atomistic Molecular Dynamics Simulations and Residue Interaction Network Analysis

Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis

(2016) Jingxu Yang et al.   Journal of Chemical Information and Modeling

Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies

(2015) Olaposi Omotuyi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response

(2015) Masaud Shah et al.   Scientific Reports

Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection

(2015) Muhammad Ayaz Anwar et al.   Scientific Reports

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

(2014) Jie Li et al.   HUMAN MUTATION

Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

(2014) Katherine L. Irvine et al.   PLoS One

The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes

(2014) Georgina L. Hold et al.   PLoS One

Allosteric signalling in the outer membrane translocation domain of PapC usher

(2014) Irene Farabella et al.   eLife

Structure and dynamic behavior of Toll-like receptor 2 subfamily triggered by malarial glycosylphosphatidylinositols ofPlasmodium falciparum

(2013) Prasannavenkatesh Durai et al.   FEBS Journal

The Structural Basis for Endotoxin-induced Allosteric Regulation of the Toll-like Receptor 4 (TLR4) Innate Immune Receptor

(2013) Teresa Paramo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid a from lipopolysaccharide recognition: Structure, dynamics and cooperativity by molecular dynamics simulations

(2013) Jose Antonio Garate et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

REVIEWING AND IDENTIFYING AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4 / MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC INNATE IMMUNITY ACTIVATION BY LPS/LIPID A, OR ANTAGONISTIC EFFECTS BY ERITORAN, IN CONTRAST TO SPECIES-DEPENDENT MODULATION BY LIPID IVA

(2013) Thomas Scior et al.   Computational and Structural Biotechnology Journal

clusterMaker: a multi-algorithm clustering plugin for Cytoscape

(2012) John H Morris et al.   BMC BIOINFORMATICS

Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

(2012) Badrinarayanan Raghavan et al.   EMBO REPORTS

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

(2012) Umeharu Ohto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Asp299Gly Polymorphism Alters TLR4 Signaling by Interfering with Recruitment of MyD88 and TRIF

(2012) L. Figueroa et al.   JOURNAL OF IMMUNOLOGY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease

(2011) A C Manolakis et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer

(2011) Annette Eyking et al.   GASTROENTEROLOGY

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

In Silico Approach to Inhibition of Signaling Pathways of Toll-Like Receptors 2 and 4 by ST2L

(2011) Shaherin Basith et al.   PLoS One

Analyzing and visualizing residue networks of protein structures

(2011) Nadezhda T. Doncheva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Different dimerisation mode for TLR4 upon endosomal acidification?

(2011) Monique Gangloff   TRENDS IN BIOCHEMICAL SCIENCES

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Expression of Functional D299G.T399I Polymorphic Variant of TLR4 Depends More on Coexpression of MD-2 Than Does Wild-Type TLR4

(2010) P. Prohinar et al.   JOURNAL OF IMMUNOLOGY

The Distinct Conformational Dynamics of K-Ras and H-Ras A59G

(2010) Suryani Lukman et al.   PLoS Computational Biology

The physical basis of model-free analysis of NMR relaxation data from proteins and complex fluids

(2009) Bertil Halle   JOURNAL OF CHEMICAL PHYSICS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE