标题
Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
作者
关键词
-
出版物
SCIENCE
Volume 367, Issue 6480, Pages 881-887
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2020-02-21
DOI
10.1126/science.aaz0326
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations
- (2019) Laura M. Wingler et al. CELL
- Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody
- (2019) Laura M. Wingler et al. CELL
- Structural basis for ligand modulation of the CCR2 conformational landscape
- (2019) Bryn C. Taylor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes
- (2019) Shoji Maeda et al. SCIENCE
- Conformational transitions of a neurotensin receptor 1–Gi1 complex
- (2019) Hideaki E. Kato et al. NATURE
- A complex structure of arrestin-2 bound to a G protein-coupled receptor
- (2019) Wanchao Yin et al. CELL RESEARCH
- The Molecular Basis of G Protein–Coupled Receptor Activation
- (2018) William I. Weis et al. Annual Review of Biochemistry
- Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure–Functional Selectivity Relationships (SFSRs) and Therapeutic Potential
- (2018) Liang Tan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Molecular mechanism of GPCR-mediated arrestin activation
- (2018) Naomi R. Latorraca et al. NATURE
- Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
- (2018) Hidetsugu Asada et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling
- (2018) Dean P. Staus et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
- (2018) Hidetsugu Asada et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
- (2018) Javier García-Nafría et al. eLife
- Structure of the µ-opioid receptor–Gi protein complex
- (2018) Antoine Koehl et al. NATURE
- Structural determinants of 5-HT2B receptor activation and biased agonism
- (2018) John D. McCorvy et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor
- (2018) Minjung Choi et al. Science Signaling
- Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors
- (2018) Yoon Namkung et al. Science Signaling
- GPCRdb in 2018: adding GPCR structure models and ligands
- (2017) Gáspár Pándy-Szekeres et al. NUCLEIC ACIDS RESEARCH
- Investigating allosteric effects on the functional dynamics of β2-adrenergic ternary complexes with enhanced-sampling simulations
- (2017) Noureldin Saleh et al. Chemical Science
- GPCR Dynamics: Structures in Motion
- (2016) Naomi R. Latorraca et al. CHEMICAL REVIEWS
- Structure of the adenosine A2A receptor bound to an engineered G protein
- (2016) Byron Carpenter et al. NATURE
- Structure-based discovery of opioid analgesics with reduced side effects
- (2016) Aashish Manglik et al. NATURE
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
- (2016) A. J. Venkatakrishnan et al. NATURE
- CHARMM36m: an improved force field for folded and intrinsically disordered proteins
- (2016) Jing Huang et al. NATURE METHODS
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography
- (2015) Haitao Zhang et al. CELL
- Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations
- (2015) Jérôme Cabana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
- (2015) Chad W. Hopkins et al. Journal of Chemical Theory and Computation
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- Insights into the Role of Asp792.50 in β2 Adrenergic Receptor Activation from Molecular Dynamics Simulations
- (2014) Anirudh Ranganathan et al. BIOCHEMISTRY
- Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)
- (2014) Ryan T. Strachan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway
- (2014) Shuguang Yuan et al. Nature Communications
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
- (2013) Romelia Salomon-Ferrer et al. Journal of Chemical Theory and Computation
- CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
- (2013) Jing Huang et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Structural Features for Functional Selectivity at Serotonin Receptors
- (2013) D. Wacker et al. SCIENCE
- Serial Femtosecond Crystallography of G Protein-Coupled Receptors
- (2013) W. Liu et al. SCIENCE
- Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
- (2012) Robert B. Best et al. Journal of Chemical Theory and Computation
- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Biased Ligands for Better Cardiovascular Drugs
- (2011) Scott M. DeWire et al. CIRCULATION RESEARCH
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
- (2011) Guillaume Lebon et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Activation mechanism of the 2-adrenergic receptor
- (2011) R. O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of an Agonist-Bound Human A2A Adenosine Receptor
- (2011) F. Xu et al. SCIENCE
- Selectively Engaging -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance
- (2010) J. D. Violin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
- (2010) Jeffery B. Klauda et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A temperature predictor for parallel tempering simulations
- (2008) Alexandra Patriksson et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Two protonation switches control rhodopsin activation in membranes
- (2008) M. Mahalingam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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