Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Opsin, a Structural Model for Olfactory Receptors?

(2013) Jung Hee Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Structure of the Human Angiotensin II Type 1 (AT1) Receptor Bound to Angiotensin II from Multiple Chemoselective Photoprobe Contacts Reveals a Unique Peptide Binding Mode

(2013) Dany Fillion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Arrestin-selective Angiotensin AT1Receptor Agonist [Sar1,Ile4,Ile8]-AngII Negatively Regulates Bradykinin B2Receptor Signaling via AT1-B2Receptor Heterodimers

(2013) Parker C. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into AT1 Receptor Activation through AngII Binding Studies

(2013) Minos-Timotheos Matsoukas et al.   Journal of Chemical Information and Modeling

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

GPCR activation: protonation and membrane potential

(2013) Xuejun C. Zhang et al.   Protein & Cell

Critical Hydrogen Bond Formation for Activation of the Angiotensin II Type 1 Receptor

(2012) Jérôme Cabana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Structural modelling and dynamics of proteins for insights into drug interactions

(2011) Tim Werner et al.   ADVANCED DRUG DELIVERY REVIEWS

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Activation mechanism of the  2-adrenergic receptor

(2011) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GROMACS-the road ahead

(2011) David van der Spoel et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Temperature dependent photolabeling of the human angiotensin II type 1 receptor reveals insights into its conformational landscape and its activation mechanism

(2010) Jason Arsenault et al.   BIOCHEMICAL PHARMACOLOGY

Scrutinizing Molecular Mechanics Force Fields on the Submicrosecond Timescale with NMR Data

(2010) Oliver F. Lange et al.   BIOPHYSICAL JOURNAL

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Biased Signaling of the Angiotensin II Type 1 Receptor Can Be Mediated through Distinct Mechanisms

(2010) Marie Mi Bonde et al.   PLoS One

The minor binding pocket: a major player in 7TM receptor activation

(2010) Mette M. Rosenkilde et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Perturbation of membranes by the amyloid β-peptide - a molecular dynamics study

(2009) Justin A. Lemkul et al.   FEBS Journal

Activation Induces Structural Changes in the Liganded Angiotensin II Type 1 Receptor

(2009) Martin Clément et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models

(2009) Catherine L. Worth et al.   PLoS One

Multiple Switches in G Protein-Coupled Receptor Activation

(2009) Shivani Ahuja et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Site-specific Cleavage of G Protein-coupled Receptor-engaged β-Arrestin

(2008) ChangWoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Molecular determinants of angiotensin II type 1 receptor functional selectivity

(2008) Mark Aplin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

A comparative molecular dynamics analysis of the amyloid β-peptide in a lipid bilayer

(2007) Justin A. Lemkul et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS