Article
Clinical Neurology
Xiaoqian Niu, Yuye Wang, Xiangfei Zhang, Yu Wang, Wen Shao, Leian Chen, Ziyuan Yang, Dantao Peng
Summary: This study investigated the diagnostic value of qEEG, APOA-I, and APOE e4 allele in aMCI and AD patients, as well as the correlation between qEEG (DTABR) and different cognitive domains. The results showed that DTABR was correlated with MMSE, MoCA, instantaneous memory, and language ability. Significant differences in DTABR were found between AD and NCs, as well as aMCI and NCs. T5 combined with APOA-I and APOE e4 had the highest AUC value (0.889) for AD diagnosis.
NEUROLOGICAL SCIENCES
(2023)
Article
Psychology, Multidisciplinary
Alison Warren
Summary: This study aims to examine the relationship between perceived stigma and perceived stress in individuals with Mild Cognitive Impairment (MCI) and their care partners, as well as the effect of a combined cognitive rehabilitation and wellness program on these perceptions.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Mingyue He, Zhan Liu, Tenghong Lian, Peng Guo, Wenjing Zhang, Yue Huang, Yanan Zhang, Gaifen Liu, Weijiao Zhang, Jinghui Li, Huiying Guan, Weijia Zhang, Dongmei Luo, Jing Qi, Hao Yue, Xiaomin Wang, Wei Zhang
Summary: This study investigated the impact of APOE epsilon 4 on cognition in patients with Alzheimer's disease. The results showed that carrying APOE epsilon 4 was associated with cognitive impairment and decreased levels of NGF in cerebrospinal fluid. Furthermore, NGF mediated the cognitive impairment associated with APOE epsilon 4.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Weihua Li, Runtian Li, Shaozhen Yan, Zhilian Zhao, Yi Shan, Zhigang Qi, Jie Lu
Summary: The study found a differential effect of APOE epsilon 4 on A beta pathology, glucose metabolism, and GM volume, with APOE epsilon 4 carriers showing a more significant impact in aMCI patients as changes in A beta deposition were studied.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Weihua Li, Runtian Li, Shaozhen Yan, Zhilian Zhao, Yi Shan, Zhigang Qi, Jie Lu
Summary: This study assessed the effects of APOE e4 on Aβ pathology, glucose metabolism, and GM volume. APOE e4 carriers showed greater baseline Aβ deposition and more significant longitudinal changes in Aβ deposition compared to noncarriers. Understanding the impact of APOE e4 on brain changes in preclinical AD is important for understanding the pathophysiology of AD at an early stage.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Huilian Duan, Yue Sun, Qian Liu, Jingzhu Fu, Ling Huang, Zehao Wang, Jing Zhao, Zhenshu Li, Wen Li, Huan Liu, Fei Ma, Yongjie Chen, Changqing Sun, Guangshun Wang, Yue Du, Guowei Huang
Summary: This study suggests that taking a nap at noon might be a potential protective factor against the development of MCI in APOE epsilon 4 non-carriers, and sleep apnea might be associated with an increased incidence of MCI in APOE epsilon 4 non-carriers.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Behavioral Sciences
Elizabeth R. Paitel, Marielle R. Samii, Kristy A. Nielson
Summary: This systematic review suggests that event-related potentials (ERPs) may be able to detect early signs of neurodegenerative diseases, particularly in the diagnosis and prediction of Alzheimer's disease (AD).
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Kalicharan Patra, Daniel Twohig, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Goril Rolfseng Grontvedt, Geir Brathen, Linda R. White, Kim Kultima, Henrietta M. Nielsen
Summary: This study found important associations between low plasma apoE levels and increased risk of Alzheimer's disease (AD), as well as progression from mild cognitive impairment to a clinical AD diagnosis.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Geriatrics & Gerontology
Bennett Kukla, Mia Anthony, Shuyi Chen, Adam Turnbull, Timothy M. Baran, Feng Lin
Summary: This study suggests that perceived fatigue is more severe in individuals with mild cognitive impairment (MCI) and may be related to altered small-worldness properties of the global brain network.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Neurosciences
Bum Soo Kim, Sungmin Jun, Heeyoung Kim
Summary: This study classified MCI patients based on cognitive trajectories and found that there are different rates of cognitive decline. Clinical and neuroimaging biomarkers are associated with cognitive decline and can provide additional information on the rate of decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Xiaotong Wei, Xiaotong Du, Yingying Xie, Xinjun Suo, Xiaoxi He, Hao Ding, Yu Zhang, Yi Ji, Chao Chai, Meng Liang, Chunshui Yu, Yong Liu, Wen Qin
Summary: By mapping the region-specific nonlinear atrophic trajectory of the whole cerebrum from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), this study found that the atrophic trajectory is quadratic accelerated, especially in the superior temporal pole, caudate, and hippocampus. Furthermore, the study revealed that APOE ε4 carriers and younger patients had faster atrophic rates in specific regions. Lastly, the identified region-specific biomarkers were able to predict AD conversion within 10 years.
Article
Food Science & Technology
Lijing Wang, Huiyan Yu, Ling Hao, Mengwei Ju, Wenjing Feng, Rong Xiao
Summary: The aim of this study is to investigate the relationship between 27-hydroxycholesterol (27-OHC), 27-hydroxylase (CYP27A1) polymorphisms, and Alzheimer's disease (AD). A case-control study was conducted and the results showed that 27-OHC level is positively associated with risk of mild cognitive impairment (MCI) and negatively associated with specific domain of cognitive function. The study also found that CYP27A1 gene polymorphisms are correlated to cognitive function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Neurosciences
Dianxu Ren, Oscar L. Lopez, Jennifer H. Lingler, Yvette Conley
Summary: The study found that the APOE epsilon 2/epsilon 4 genotype is not significantly associated with the risk of Alzheimer's disease and mild cognitive impairment among African Americans.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Tingting Mu, Jiaqi Wei, Jun Sun, Junyan Jin, Tong Zhang, Hao Wu, Bin Su
Summary: The study aimed to analyze the association between APOE ε4 and cognitive impairment in HIV patients. The results showed a significant association between APOE ε4 and global cognitive impairment, particularly in specific cognitive domains. This finding could contribute to a better understanding and management of cognitive issues in HIV patients.
CHINESE MEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Jennifer C. Howell, William T. T. Hu, Kim Kultima, Henrietta M. Nielsen
Summary: Differences in plasma apoE levels and dimer formation may contribute to the racial disparity in risk of Alzheimer's disease between Black/African-Americans and non-Hispanic whites.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Ali Ezzati, Cuiling Wang, Mindy J. Katz, Carol A. Derby, Andrea R. Zammit, Molly E. Zimmerman, Jelena M. Pavlovic, Martin J. Sliwinski, Richard B. Lipton
CURRENT ALZHEIMER RESEARCH
(2019)
Article
Neurosciences
Andrea R. Zammit, Graciela Muniz-Terrera, Mindy J. Katz, Charles B. Hall, Ali Ezzati, David A. Bennett, Richard B. Lipton
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Geriatrics & Gerontology
Ali Ezzati, Mindy J. Katz, Carol A. Derby, Molly E. Zimmerman, Richard B. Lipton
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2019)
Article
Clinical Neurology
Ali Ezzati, Andrea R. Zammit, Mindy J. Katz, Carol A. Derby, Molly E. Zimmerman, Richard B. Lipton
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2019)
Article
Neuroimaging
Ali Ezzati, Andrea R. Zammit, Christian Habeck, Charles B. Hall, Richard B. Lipton
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Clinical Neurology
Ali Ezzati, Andrea R. Zammit, Michael L. Lipton, Richard B. Lipton
PSYCHIATRY RESEARCH-NEUROIMAGING
(2019)
Article
Clinical Neurology
Andrea R. Zammit, Charles B. Hall, David A. Bennett, Ali Ezzati, Mindy J. Katz, Graciela Muniz-Terrera, Richard B. Lipton
ALZHEIMERS & DEMENTIA
(2019)
Article
Neurosciences
Ali Ezzati, Andrea R. Zammit, Danielle J. Harvey, Christian Habeck, Charles B. Hall, Richard B. Lipton
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Neurosciences
Ali Ezzati, Richard B. Lipton
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Clinical Neurology
Ali Ezzati, Ahmed Abdulkadir, Clifford R. Jack, Paul M. Thompson, Danielle J. Harvey, Monica Truelove-Hill, Lasya P. Sreepada, Christos Davatzikos, Richard B. Lipton
Summary: The study evaluated the value of the ATN biomarker classification system in predicting conversion from MCI to dementia, with data-driven approaches showing better performance in this prediction. Both classifiers using clinical features and classifiers using ATN biomarkers performed equally well in predicting progression to dementia.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Ali Ezzati, Kristina M. Fanning, Dawn C. Buse, Jelena M. Pavlovic, Cynthia E. Armand, Michael L. Reed, Vincent T. Martin, Richard B. Lipton
Summary: This study aims to identify predictors of acute treatment response for nonprescription medications among people with migraine and develop improved models for predicting treatment response.
Article
Clinical Neurology
Ali Ezzati, Dawn C. Buse, Kristina M. Fanning, Michael L. Reed, Vincent T. Martin, Richard B. Lipton
Summary: This study aimed to identify predictors of acute treatment optimization among people with episodic migraine. The results showed that men, individuals with higher average headache pain intensity, higher migraine symptom severity scores, presence of cutaneous allodynia, and depression had reduced odds of adequate 2-hour pain freedom response. Adequate 24-hour pain relief was associated with being married, but declined in those with higher-than-average average headache pain intensity and frequency, greater disability, presence of cutaneous allodynia, and depression. Participants taking triptans were more likely to have adequate treatment response compared to those taking butalbital combination medications (BCMs) and opioids. There was no significant difference in response to treatment between participants taking BCMs and opioids.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Clinical Neurology
Ali Ezzati, Kristina M. Fanning, Michael L. Reed, Richard B. Lipton
Summary: The objective of this study was to identify predictors of acute treatment optimization for migraine with over-the-counter (OTC) medications and to develop predictive models for each class of OTC medication. The study analyzed data from 2224 participants and found that a large subgroup of people with migraine had an inadequate response to their usual OTC migraine treatment. Predictive models identified several factors associated with better treatment response in each class of OTC medication. These findings suggest a need to improve OTC treatment for some and to offer prescription acute medications for others.
Article
Clinical Neurology
Ellen Grober, Kellen K. Petersen, Richard B. Lipton, Jason Hassenstab, John C. Morris, Brian A. Gordon, Ali Ezzati
Summary: This study used the SOMI system to identify individuals with subtle cognitive impairment among those who appear to be cognitively normal. The results showed that participants with retrieval impairment (SOMI-1) had a higher incidence of cognitive impairment, and the risk increased even more for those with storage impairment (SOMI-3/4), after adjusting for demographics and APOE ε4 status. Additionally, the study found that SOMI remained a significant predictor of incident cognitive impairment even after considering biomarkers of β-amyloid, tau pathology, and neurodegeneration.
Article
Clinical Neurology
Ali Ezzati, Christos Davatzikos, David A. Wolk, Charles B. Hall, Christian Habeck, Richard B. Lipton
Summary: This article investigates the application of predictive models in Alzheimer's disease clinical trials to enhance the efficacy by selecting and excluding patients unlikely to show cognitive decline.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)