Review
Neurosciences
Claudia Perez-Cruz, Juan de Dios Rodriguez-Callejas
Summary: Human life expectancy is increasing, leading to a rise in the incidence of dementia in the older population. Animal models, particularly nonhuman primates like the common marmoset, offer significant advantages in studying neurodegenerative diseases. Marmosets have physiological adaptations and metabolic alterations associated with the increased risk of dementia in humans, making them a valuable model for understanding aging and neurodegeneration.
TRENDS IN NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Daniel Giovinazzo, Biljana Bursac, Juan Sbodio, Sumedha Nalluru, Thibaut Vignane, Adele M. Snowman, Lauren M. Albacarys, Thomas W. Sedlak, Roberta Torregrossa, Matthew Whiteman, Milos R. Filipovic, Solomon H. Snyder, Bindu D. Paul
Summary: Alzheimer's disease is characterized by memory, executive, and motor function deterioration, with neuropathological hallmarks including neurofibrillary tangles, paired helical filaments, and amyloid plaques. Dysregulation of signaling by hydrogen sulfide has been shown during aging and may play a role in preventing hyperphosphorylation of Tau in Alzheimer's disease. Furthermore, administering the H2S donor sodium GYY4137 to mouse models of Alzheimer's disease has been shown to ameliorate motor and cognitive deficits associated with the disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Courtney Glavis-Bloom, Casey R. Vanderlip, John H. Reynolds
Summary: Research on aging marmosets has shown that aged animals exhibit delayed onset of learning, slowed learning rate after onset, and decreased asymptotic working memory performance, which are not accounted for by age-related impairments in motor speed and motivation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Angel Cores, Noelia Carmona-Zafra, Olmo Martin-Camara, Juan Domingo Sanchez, Pablo Duarte, Mercedes Villacampa, Paloma Bermejo-Bescos, Sagrario Martin-Aragon, Rafael Leon, J. Carlos Menendez
Summary: Curcumin analogues with the fragment of piperlongumine showed broad-spectrum activity in the treatment of Alzheimer's disease, with good absorption, antioxidant properties, and the ability to inhibit inflammation.
Article
Multidisciplinary Sciences
Christine Rother, Ruth E. Uhlmann, Stephan A. Mueller, Juliane Schelle, Angelos Skodras, Ulrike Obermuller, Lisa M. Hasler, Marius Lambert, Frank Baumann, Ying Xu, Carina Bergmann, Giulia Salvadori, Maarten Loos, Irena Brzak, Derya Shimshek, Ulf Neumann, Lary C. Walker, Stephanie A. Schultz, Jasmeer P. Chhatwal, Stephan A. Kaeser, Stefan F. Lichtenthaler, Matthias Staufenbiel, Mathias Jucker
Summary: This study reveals a temporal dissociation between brain Aβ deposition and neurodegeneration, providing new insights into the pathogenesis of Alzheimer's disease.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Catia Correia-Caeiro, Anne Burrows, Duncan Andrew Wilson, Abdelhady Abdelrahman, Takako Miyabe-Nishiwaki
Summary: This article discusses the role of facial expressions in mammals, focusing on the study of facial expressions and movements in common marmosets. The research method for analyzing facial expressions is introduced, highlighting the importance of facial expressions in social interactions for common marmosets.
Article
Clinical Neurology
Boram Kim, Bailey Mikytuck, Eunran Suh, Garrett S. Gibbons, Vivianna M. Van Deerlin, Sanjeev N. Vaishnavi, Meredith A. Spindler, Lauren Massimo, Murray Grossman, John Q. Trojanowski, David J. Irwin, Edward B. Lee
Summary: The study found that Gosuranemab treatment did not lead to clearance of neuropathologic FTLD-tau inclusions, but did induce changes including the presence of perivascular vesicular astrocytes (PVA) with tau accumulation within lysosomes. These results suggest that Gosuranemab may be associated with a glial response involving tau accumulation within astrocytic lysosomes.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Anastasie Mate De Gerando, Lindsay A. Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E. Chun, Romain Perbet, Bradley T. Hyman
Summary: Insoluble fibrillar tau has long been considered the active form of tau in Alzheimer's disease, but recent studies have shown that soluble oligomeric tau may also play a role in tau propagation. In this study, we compared the properties of insoluble fibrillar tau and soluble high molecular weight (HMW) tau from Alzheimer patients. We found that both forms of tau are potent in seeding tau aggregates, but HMW tau appears to be more effective in inducing glial responses and promoting the spread of misfolded tau to other brain regions. These findings suggest that HMW tau may be more bioactive in tau-related Alzheimer phenotypes.
ACTA NEUROPATHOLOGICA
(2023)
Article
Anatomy & Morphology
Silke Haverkamp, Matthias Mietsch, Kevin L. Briggman
Summary: This study provides a first-time description of the structural characteristics and morphological differences of the common marmoset retina. The finding of misplaced ganglion cells and misplaced bipolar cell axon terminals has important implications for future research on the physiological and functional impact.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairajan
Summary: This study found that KIF5B is involved in tau homeostasis in AD cells and animal models. By decreasing KIF5B levels, abnormal tau behavior can be reduced, thereby preventing and slowing down AD and other tauopathies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Catia Correia-Caeiro, Anne Burrows, Duncan Andrew Wilson, Abdelhady Abdelrahman, Takako Miyabe-Nishiwaki
Summary: Facial expressions are crucial cues for communication and conveying emotions in mammals. CalliFACS, a scientific tool developed for common marmosets, allows objective measurement and better understanding of their facial movements and expressions.
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Environmental Sciences
Jing Li, Junxiang Wang, Yuan-Liang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan Li
Summary: Cobalt nanoparticles (CoNPs) induce neurotoxicity by activating NOX2, resulting in ROS production, Tau protein phosphorylation, and inflammation in the brain.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Anastasia Noel, Benedicte Foveau, Andrea C. LeBlanc
Summary: The co-expression of active hCasp6 and hTau leads to Tau cleavage and rare age-dependent argentophilic deposits, but does not induce cognitive deficits, neuroinflammation, and Tau pathology.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb
Summary: This study reveals that Cx3cr1 deficiency impairs the uptake and degradation of A beta by microglia, leading to increased accumulation of neurotoxic A beta species. Additionally, the loss of Cx3cr1 results in dysfunctional microglia characterized by dampened TGF beta signaling, increased oxidative stress responses, and dysregulated pro-inflammatory activation. These findings highlight the significant role of Cx3cr1 in modulating neurodegeneration and cognitive function.
MOLECULAR NEURODEGENERATION
(2022)