Article
Neurosciences
Philip S. Insel, Michael C. Donohue, David Berron, Oskar Hansson, Niklas Mattsson-Carlgren
Summary: The study revealed that changes in key pathological markers A beta and tau in Alzheimer's disease may occur several decades or years before A beta-positivity, while cognitive dysfunction may appear 4-6 years before A beta-positivity, providing potential windows for specific treatments.
Article
Clinical Neurology
Emma M. Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M. Tijms, Luigi Lorenzini, Mara ten Kate, Lyduine E. Collij, Fiona Heeman, Roos M. Rikken, Sophie M. van der Landen, Marijke E. den Hollander, Sandeep S. Golla, Maqsood Yaqub, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Eco J. C. de Geus, Pieter Jelle Visser, Bart N. M. van Berckel, Anouk den Braber
Summary: The amyloid cascade hypothesis has played a significant role in Alzheimer's disease research and clinical trial designs. This study investigated the relationship between amyloid-beta and tau at the individual and twin-pair levels, aiming to rule out genetic and shared environmental effects as confounders. The findings suggest that the associations between amyloid-beta, tau, neurodegeneration, and cognition are unbiased by genetic factors, and the effects of amyloid-beta on neurodegeneration and cognitive decline are mediated by tau.
Article
Clinical Neurology
Dustin R. Wakeman, Michael R. Weed, Sylvia E. Perez, Erika N. Cline, Kirsten L. Viola, Kyle C. Wilcox, David S. Moddrelle, Ernell Z. Nisbett, Anish M. Kurian, Amanda F. Bell, Ricaldo Pike, Peer B. Jacobson, William L. Klein, Elliott J. Mufson, Matthew S. Lawrence, John D. Elsworth
Summary: The use of nonhuman primates as a model for Alzheimer's disease can help to better understand the pathology of the disease.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Clinical Neurology
Geoffroy Gagliardi, Madeline Kuppe, Cristina Lois, Bernard Hanseeuw, Patrizia Vannini
Summary: Impaired self-awareness of memory function, a common symptom in Alzheimer's disease, is associated with higher levels of tau pathology rather than amyloidosis. Discordant subjective and objective memory measures may be clinically significant in the evaluation of AD progression.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Virology
Erin E. Sundermann, Laura M. Campbell, Olivia Villers, Mark W. Bondi, Ben Gouaux, David P. Salmon, Douglas Galasko, Virawudh Soontornniyomkij, Ronald J. Ellis, David J. Moore
Summary: We examined the prevalence of AD pathological hallmarks in HIV-infected individuals and found that AD pathology was less prevalent and less severe in HIV-positive individuals compared to HIV-negative individuals. AD pathology was most consistently related to memory-related domains in HIV-positive individuals. Further studies are needed to investigate the effect of HIV status on AD pathology.
Article
Neurosciences
Tatiana M. Corey, Oscar Illanes, Matthew Lawrence, Sylvia E. Perez, Shervin Liddie, John J. Callanan
Summary: Nonhuman primates (NHPs) are crucial for studying the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease (AD), and evaluating potential therapies. In this study, the authors focused on the St. Kitts African green monkey (AGM) to understand the age-related neuropathology and age progression of AD-associated pathology. They found age-related microscopic findings in AGM brains, including astrocytosis and neuronal lipofuscinosis, as well as AD-related pathology, such as A beta plaques and increased GFAP expression, in older animals. This research emphasizes the importance of AGM as a natural model for studying neurodegenerative diseases.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Neurosciences
Lei Huang, Yang Zhang, Yongwei Wang, Yajia Lan
Summary: Degenerative dementia, including Alzheimer's disease, is characterized by gradual deterioration of cognitive function. Chronic noise exposure has been identified as a potential risk factor for cognitive impairment and degenerative dementia, accelerating cognitive dysfunction and pathological changes in the brain. Epidemiological studies are increasingly investigating the association between external noise exposure and dementia, highlighting the need for further research in this area.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Giulia Bivona, Matilda Iemmolo, Tommaso Piccoli, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Giulio Ghersi
Summary: Alzheimer's disease (AD) is the most common form of cognitive decline, characterized by aggregates of A beta and tau protein. In addition to A beta deposition, inflammation and microglia activation in the brain may also play a role in the pathogenesis of AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li
Summary: Extracellular neuritic plaques and intracellular neurofibrillary tangles, composed of amyloid-beta and phosphorylated tau protein respectively, are hallmark proteins of Alzheimer's disease. The interactions between these proteins have been extensively studied, with A beta accelerating tau phosphorylation, tau mediating A beta toxicity, and potential synergistic effects on microglial cells and astrocytes. Understanding these interactions may lead to new interventions against Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Mohammad Rafi Khezri, Keyvan Yousefi, Negin Mahboubi, Darya Hodaei, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder worldwide, and its association with diseases like diabetes has been well-studied. Metformin, a medication commonly used for type 2 diabetes, has shown potential disease-modifying effects on various aspects of AD pathophysiology.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Deborah Inyang, Tasneem Saumtally, Chinelo Nonyerem Nnadi, Sharmila Devi, Po-Wah So
Summary: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment and specific neuropathological changes. Capsaicin, a compound found in chili peppers, has shown anti-inflammatory, antioxidant, and potential neuroprotective properties. Studies have suggested that capsaicin intake may improve cognitive function and reduce tau pathology in AD. This systematic review discusses the potential benefits of capsaicin in improving AD pathology and symptoms based on studies using animal models and cell cultures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Amy F. T. Arnsten, Dibyadeep Datta, Kelly Del Tredici, Heiko Braak
Summary: The etiology of common, sporadic Alzheimer's disease is unknown. The hypothesis proposed here suggests that tau pathology within specific projection neurons in susceptible microenvironments may initiate sAD, supported by data showing tau pathology appearing a decade before A beta plaques and targeting glutamate projection neurons.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Chemistry, Medicinal
Jack D. Scott, Duane E. DeMong, Thomas J. Greshock, Kallol Basu, Xing Dai, Joel Harris, Alan Hruza, Sarah W. Li, Sue-Ing Lin, Hong Liu, Megan K. Macala, Zhiyong Hu, Hong Mei, Honglu Zhang, Paul Walsh, Marc Poirier, Zhi-Cai Shi, Li Xiao, Gautam Agnihotri, Marco A. S. Baptista, John Columbus, Matthew J. Fell, Lynn A. Hyde, Reshma Kuvelkar, Yinghui Lin, Christian Mirescu, John A. Morrow, Zhizhang Yin, Xiaoping Zhang, Xiaoping Zhou, Ronald K. Chang, Mark W. Embrey, John M. Sanders, Heather E. Tiscia, Robert E. Drolet, Jonathan T. Kern, Sylvie M. Sur, John J. Renger, Mark T. Bilodeau, Matthew E. Kennedy, Eric M. Parker, Andrew W. Stamford, Ravi Nargund, John A. McCauley, Michael W. Miller
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Lihang Yao, Andres D. Ramirez, Anthony J. Roecker, Steven V. Fox, Jason M. Uslaner, Sean M. Smith, Robert Hodgson, Paul J. Coleman, John J. Renger, Christopher J. Winrow, Anthony L. Gotter
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Neurosciences
Laura A. Grafe, Darrell Eacret, Sandra Luz, Anthony L. Gotter, John J. Renger, Chris J. Winrow, Seema Bhatnagar
Meeting Abstract
Clinical Neurology
P. Jiang, J. R. Scarpa, V. D. Gao, K. Fitzpatrick, A. Gotter, C. J. Winrow, J. J. Renger, M. H. Vitaterna, A. Kasarskis, F. W. Turek
Meeting Abstract
Clinical Neurology
A. L. Gotter, J. Stevens, S. L. Garson, S. Fox, V Svetnik, P. L. Tannenbaum, M. S. Forman, P. J. Coleman, W. J. Herring, J. J. Renger, C. J. Winrow
Article
Behavioral Sciences
Darrell Eacret, Laura A. Grafe, Jane Dobkin, Anthony L. Gotter, John J. Renger, Christopher J. Winrow, Seema Bhatnagar
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Multidisciplinary Sciences
Joseph R. Scarpa, Peng Jiang, Vance D. Gao, Karrie Fitzpatrick, Joshua Millstein, Christopher Olker, Anthony Gotter, Christopher J. Winrow, John J. Renger, Andrew Kasarskis, Fred W. Turek, Martha H. Vitaterna
Meeting Abstract
Neurosciences
Stacey Versavel, Rachel Gurrell, Ih Chang, Ann Dandurand, Sridhar Duvvuri, Amy Giugliano, Gina Pastino, Theresa Pham, Gabriel Jacobs, Koshar Safai Pour, Rob Zuiker, Raymond Sanchez, John Renger
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
John H. Krystal, John M. Kane, Christoph U. Correll, David P. Walling, Matthew Leoni, Sridhar Duvvuri, Shrinal Patel, Ih Chang, Philip Iredale, Lillian Frohlich, Stacey Versavel, Pamela Perry, Raymond Sanchez, John Renger
Summary: The trial involved two parts with a total of 167 schizophrenia patients. The results showed that emraclidine once-daily treatment had good safety and tolerability, demonstrating potential for further investigation as a treatment for schizophrenia.
Meeting Abstract
Neurosciences
Sridhar Duvvuri, Philip Iredale, Matthew Leoni, Vasily Belov, Nicolas Guehl, Sung-Hyun Moon, Maeva Dhaynaut, Peter Rice, Daniel Yokell, Georges El Fakhri, Marc Normandin, John Renger
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
John Krystal, John Kane, Christoph Correll, David Walling, Matthew Leoni, Sridhar Duvvuri, Ih Chang, Philip Iredale, Stacey Versavel, Lillian Frohlich, Shrinal PatelPamela Perry, Raymond Sanchez, John Renger
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
Vasily Belov, Nicolas J. Guehl, Sridhar Duvvuri, Philip Iredale, Sung-Hyun Moon, Maeva Dhaynaut, Peter A. Rice, Daniel L. Yokell, John Renger, Georges El Fakhri, Marc D. Normandin
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Rahul Sasane, Amy Bartels, Michelle Field, Maria I. Sierra, Sridhar Duvvuri, David L. Gray, Sokhom S. Pin, John J. Renger, David J. Stone
Summary: The study found that tamsulosin users had a significantly higher incidence of Parkinson's disease compared to terazosin/alfuzosin/doxazosin users and matched controls. There was no significant difference in Parkinson's disease risk between terazosin/alfuzosin/doxazosin users and matched controls. These results suggest that tamsulosin may exacerbate Parkinson's disease progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Chemistry, Medicinal
Jason W. Skudlarek, Christina N. DiMarco, Kerim Babaoglu, Anthony J. Roecker, Joseph G. Bruno, Mark A. Pausch, Julie A. O'Brien, Tamara D. Cabalu, Joanne Stevens, Joseph Brunner, Pamela L. Tannenbaum, W. Peter Wuelfing, Susan L. Garson, Steven V. Fox, Alan T. Savitz, Charles M. Harrell, Anthony L. Gotter, Christopher J. Winrow, John J. Renger, Scott D. Kuduk, Paul J. Coleman
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
