Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats

(2018) Jing Yu et al.   EXPERIMENTAL NEUROLOGY

Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

(2018) Shengpan Chen et al.   Journal of Neuroinflammation

Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats

(2018) Nathanael Matei et al.   JOURNAL OF NEUROSCIENCE

Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after MCAO in rats

(2018) Guangyong Wu et al.   NEUROBIOLOGY OF DISEASE

Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats

(2018) Ningbo Xu et al.   NEUROPHARMACOLOGY

Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats

(2018) Zhiyi Xie et al.   NEUROPHARMACOLOGY

Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion

(2018) Devin William McBride et al.   Translational Stroke Research

PAI-1 but Not PAI-2 Gene Deficiency Attenuates Ischemic Brain Injury After Experimental Stroke

(2018) Eva-Verena Griemert et al.   Translational Stroke Research

The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway

(2018) Wei-Yin Wu et al.   Frontiers in Pharmacology

Post-stroke DHA Treatment Protects Against Acute Ischemic Brain Injury by Skewing Macrophage Polarity Toward the M2 Phenotype

(2018) Wei Cai et al.   Translational Stroke Research

Inhibition of Myeloperoxidase byN-Acetyl Lysyltyrosylcysteine Amide Reduces Oxidative Stress–Mediated Inflammation, Neuronal Damage, and Neural Stem Cell Injury in a Murine Model of Stroke

(2017) Guoliang Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat

(2017) Keren Zhou et al.   STROKE

Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis

(2017) Jing Tian et al.   Translational Stroke Research

Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway

(2017) Srinivasan V. Narayanan et al.   Translational Stroke Research

Effects of simvastatin, ezetimibe and simvastatin/ezetimibe on mitochondrial function and leukocyte/endothelial cell interactions in patients with hypercholesterolemia

(2016) Antonio Hernandez-Mijares et al.   ATHEROSCLEROSIS

Electroacupuncture Attenuates Cerebral Ischemia and Reperfusion Injury in Middle Cerebral Artery Occlusion of Rat via Modulation of Apoptosis, Inflammation, Oxidative Stress, and Excitotoxicity

(2016) Mei-hong Shen et al.   Evidence-based Complementary and Alternative Medicine

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

(2016) Jing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke

(2016) Yi-Je Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of ezetimibe and anticoagulant combined therapy on progressing stroke: a randomized, placebo-controlled study

(2016) Lan Yang et al.   JOURNAL OF NEUROLOGY

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Anti-neuroinflammatory Effect of Emodin in LPS-Stimulated Microglia: Involvement of AMPK/Nrf2 Activation

(2016) Sun Young Park et al.   NEUROCHEMICAL RESEARCH

Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II – induced hypothalamic reactive oxygen species and hypertension

(2016) Hong-Wei Wang et al.   NEUROSCIENCE

Role of the AMPK signaling pathway in early brain injury after subarachnoid hemorrhage in rats

(2015) Ji-Yang An et al.   ACTA NEUROCHIRURGICA

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Blood-brain barrier dysfunction in disorders of the developing brain

(2015) Raffaella Moretti et al.   Frontiers in Neuroscience

Experimental research Influence of ezetimibe on selected parameters of oxidative stress in rat liver subjected to ischemia/reperfusion

(2014) Małgorzata Trocha et al.   Archives of Medical Science

Inhibition of Smooth Muscle Cell Proliferation by Ezetimibe via the Cyclin D1-MAPK Pathway

(2014) Li Qin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion

(2014) Małgorzata Trocha et al.   Pharmacological Reports

Improved neurocognitive functions correlate with reduced inflammatory burden in atrial fibrillation patients treated with intensive cholesterol lowering therapy

(2013) Knut Tore Lappegård et al.   Journal of Neuroinflammation

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potential of ezetimibe in memory deficits associated with dementia of alzheimer′s type in mice

(2010) Nirmal Singh et al.   INDIAN JOURNAL OF PHARMACOLOGY

Inflammasomes and autoimmunity

(2010) Patrick J. Shaw et al.   TRENDS IN MOLECULAR MEDICINE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner

(2009) Tsukasa Nakamura et al.   PHARMACOLOGICAL RESEARCH