Article
Immunology
Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang
Summary: Activation of TGR5 mitigates brain injury by inhibiting neuroinflammation after MCAO, potentially mediated by Pellino3 inhibition of caspase-8/NLRP3.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Michael Bieber, Michael K. Schuhmann, Maximilian Bellut, David Stegner, Katrin G. Heinze, Mirko Pham, Bernhard Nieswandt, Guido Stoll
Summary: This study demonstrates that combining neuroprotective and anti-platelet interventions can enhance therapeutic effects in patients with ischemic stroke, providing new insights for the clinical treatment of hyper-acute stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Summary: Progressive brain infarction can be delayed by blocking detrimental lymphocyte/platelet responses during occlusion, paving the way for ultra-early treatment strategies in hyper-acute stroke before recanalization.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, Yuan Wang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Chronic remote ischemic conditioning (RIC) appears to be well-tolerated and associated with a low annual risk of ischemic stroke and cardio-cerebrovascular events in patients with symptomatic internal carotid artery or middle cerebral artery occlusion with impaired hemodynamics.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Manish Kumar, Gurteg Singh, Ajay Singh Kushwah, Gurunath Surampalli, Thakur Gurjeet Singh, Sushma Gupta
Summary: The study showed that arbutin can protect against ischemia-reperfusion injury and alleviate neurobehavioral deficits in the MCAo/R mouse model. It was also found that arbutin can decrease brain acetylcholinesterase activity and glutamate levels, while increasing GABA levels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Justin P. Van Beusecum, Natalia R. Barbaro, Charles D. Smart, David M. Patrick, Roxana Loperena, Shilin Zhao, Nestor de la Visitacion, Mingfang Ao, Liang Xiao, Cyndya A. Shibao, David G. Harrison
Summary: This study demonstrates an increase in circulating AS DCs in hypertensive patients, with Axl signaling playing a critical role in promoting their formation. The research also reveals the significant involvement of GAS6 and Axl signaling in immune cells and endothelial cells in hypertension.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuelin Zhao, Xiaohua Shi, Jiaoqi Wang, Jing Mang, Zhongxin Xu
Summary: The study found that betulinic acid can reduce cerebral injury by decreasing oxidative stress, as well as activate the SIRT1/FoxO1 pathway to suppress autophagy and improve cerebral injury.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mengyuan Li, Wen Xue, Xinhua Li, Yaxiang Song, Xinying Liu, Ling Qin
Summary: This study found that inflammatory cytokines, sAxl, and Gas6 levels were significantly increased in HD patients, with sAxl positively correlated with IL-6. mAxl in CD14(+) mononuclear cells and CD19(+) B cells was elevated in HD patients. Furthermore, the metalloproteinase ADAM17 contributed to the cleavage of mAxl into sAxl.
MOLECULAR IMMUNOLOGY
(2021)
Article
Clinical Neurology
Andrea Naldi, Alessandra Di Liberto, Enrica Duc, Alessandro Rapellino, Giacomo Paolo Vaudano, Roberto Cavallo, Andrea Boghi
Summary: Bilateral simultaneous middle cerebral artery occlusion is a rare condition that requires rapid intervention for restoring brain perfusion. Perfusion-computed tomography is essential for selecting stroke patients for mechanical thrombectomy, but its role in guiding the optimal treatment strategy for concomitant multivessel cerebral occlusion has not been reported before. This case study highlights the importance of perfusion-computed tomography in both guiding endovascular procedures and planning the sequence of mechanical thrombectomies for bilateral middle cerebral artery occlusion.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang
Summary: Ischemic stroke is a common type of stroke that has a significant impact on human well-being and quality of life. To better understand the pathophysiology of ischemic stroke and develop new treatment strategies, controllable and consistent animal models are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used model for studying ischemic stroke. This review discusses different methods for constructing the MCAO model and compares their advantages and disadvantages, aiming to provide better approaches for studying ischemic stroke.
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Xiangjun Xu, Ke Yang, Junfeng Xu, Qian Yang, Yapeng Guo, Youqing Xu, Hao Wang, Liang Ge, Zhiming Zhou, Xianjun Huang
Summary: This study aimed to evaluate the differences in endovascular treatment outcomes among MCAO patients with different pathologic subtypes. The results showed that patients with different etiologies had comparable successful recanalization rates and functional independence at 90 days.
Article
Neurosciences
Jikai Wang, Yuchun Zuo, Kai Zhuang, Kui Luo, Xiaoxin Yan, Jianming Li, John H. Zhang, Fei Liu
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Review
Neurosciences
Ling-Yun Wu, Budbazar Enkhjargal, Zhi-Yi Xie, Zachary D. Trayis, Cheng-Mei Sun, Ke-Ren Zhou, Tong-Yu Zhang, Qi-Quan Zhu, Chun-Hua Hang, John H. Zhang
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Pinar Eser Ocak, Umut Ocak, Prativa Sherchan, Marcin Gamdzyk, Jiping Tang, John H. Zhang
EXPERIMENTAL NEUROLOGY
(2020)
Article
Endocrinology & Metabolism
Zhenhua Zhou, Ningbo Xu, Nathanael Matei, Devin W. McBride, Yan Ding, Hui Liang, Jiping Tang, John H. Zhang
Summary: The study demonstrated that intranasal administration of sodium butyrate reduced infarct volume and improved neurological function after middle cerebral artery occlusion (MCAO) in rats. The mechanism involved the activation of the PI3K/Akt pathway via GPR41/G beta gamma, leading to attenuation of neuronal apoptosis.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Lei Huang, Cameron Lenahan, Warren Boling, Jiping Tang, John H. Zhang
Summary: Stroke is a major global health concern with limited effective treatments. Molecular hydrogen, as a novel medical gas, shows therapeutic potential for neurological diseases, including stroke. Studies have demonstrated neuroprotective effects of molecular hydrogen therapy in stroke patients and models, providing new insights for stroke treatment.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Endocrinology & Metabolism
Richard Camara, Nathanael Matei, John H. Zhang
Summary: Although many patients are not eligible for reperfusion within 24 hours according to current guidelines, case studies show favorable outcomes for delayed recanalization beyond 24 hours after symptom onset. Modern imaging techniques aid in identifying penumbra and improving understanding of reperfusion risks and complications. There is an urgent need to further comprehend the pathophysiologic mechanisms and optimal conditions for delayed recanalization after 24 hours of ischemia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Cell Biology
Shengpeng Liu, Jerry J. Flores, Bo Li, Shuixiang Deng, Gang Zuo, Jun Peng, Jiping Tang, John H. Zhang
Summary: This study found that rIL-19 treatment improved hematoma clearance and reduced neurological deficits after GMH by upregulating the IL-20R1/ERK/Nrf2 signaling pathway, suggesting a promising therapeutic strategy for GMH patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Qin Zhang, Mei Zheng, Cristian E. Betancourt, Lifeng Liu, Albert Sitikov, Nikola Sladojevic, Qiong Zhao, John H. Zhang, James K. Liao, Rongxue Wu
Summary: The study found that MMP3 affects the permeability of the BBB through upregulation of the ERK signaling pathway, leading to a decrease in TJ and VE-cadherin proteins in BMVECs.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Li Li, Cameron Lenahan, Zhihui Liao, Jingdong Ke, Xiuliang Li, Fushan Xue, John H. Zhang
Summary: The immune system plays a crucial role in brain damage and recovery, but the biology of immune response in the brain is still poorly understood due to the complexity of the central nervous system and technological limitations. Novel technologies such as single-cell RNA analysis and cytometry by time-of-flight are being utilized to study brain immune response and may provide a promising future for brain repair.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen-Xiong Chen, John H. Zhang
Summary: The activation of MC1R with BMS-470539 attenuates oxidative stress and neuronal apoptosis in a neonatal HI rat model, improving neurological deficits. This effect is partially mediated by the MC1R/cAMP/PKA/Nurr1 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Clinical Neurology
Jun Yan, Weilin Xu, Cameron Lenahan, Lei Huang, Jing Wen, Gaigai Li, Xin Hu, Wen Zheng, John H. Zhang, Jiping Tang
Summary: The study revealed that CCR5 activation can promote neuronal pyroptosis and neurological deficits after experimental intracerebral hemorrhage, partially through the CCR5/PKA/CREB/NLRP1 signaling pathway. Administration of the selective antagonist of CCR5, Maraviroc, improved neurobehavioral deficits and decreased neuronal pyroptosis, offering a promising therapeutic approach in managing patients with ICH.
Article
Cardiac & Cardiovascular Systems
Reng Ren, Qin Lu, Prativa Sherchan, Yuanjian Fang, Cameron Lenahan, Lihui Tang, Yi Huang, Rui Liu, John H. Zhang, Jianmin Zhang, Jiping Tang
Summary: The study demonstrates the crucial role of AHR in hyperglycemia-induced hematoma expansion after ICH. Inhibition of AHR can provide neurological benefits by restricting hematoma expansion and preserving BBB function. AHR may serve as a potential therapeutic target to attenuate hyperglycemia-induced complications in ICH patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Jinwei Pang, Nathanael Matei, Jianhua Peng, Wen Zheng, Jing Yu, Xu Luo, Richard Camara, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
Summary: Delayed recanalization at day 3 postinfarct can significantly improve neurological outcomes after ischemic stroke. Macrophages play a critical role in this process by promoting angiogenesis and reducing neurodegeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)