Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis

The in vivo evidence for regulated necrosis

(2017) Wulf Tonnus et al.   IMMUNOLOGICAL REVIEWS

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats

(2017) Rongli Yang et al.   NEUROSCIENCE LETTERS

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Necroptosis in neurodegenerative diseases: a potential therapeutic target

(2017) Shuo Zhang et al.   Cell Death & Disease

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine

(2016) Gabriel Moreno-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

(2016) Jun Zhang et al.   ARCHIVES OF TOXICOLOGY

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line

(2016) Ruchi Mishra et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway

(2015) Claudia Filozof et al.   DRUGS

Revisiting Cerebral Postischemic Reperfusion Injury: New Insights in Understanding Reperfusion Failure, Hemorrhage, and Edema

(2015) Jilin Bai et al.   International Journal of Stroke

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke

(2015) A P Shabanzadeh et al.   Cell Death & Disease

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

(2015) A Fauster et al.   Cell Death & Disease

The synergetic effect of edaravone and borneol in the rat model of ischemic stroke

(2014) Hai-Yin Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Progesterone in transient ischemic stroke: a dose–response study

(2014) Seema Yousuf et al.   PSYCHOPHARMACOLOGY

Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes

(2013) Si-Hai Fu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Hydroxysafflor yellow a protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats

(2008) Sheng-Ying Ye et al.   ARCHIVES OF PHARMACAL RESEARCH

Total saponins of Panax Notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion

(2008) Hua Li et al.   JOURNAL OF ETHNOPHARMACOLOGY