Targeting Age-Dependent Functional and Metabolic Decline of Human Skeletal Muscle: The Geroprotective Role of Exercise, Myokine IL-6, and Vitamin D

Roles of myokines in exercise-induced improvement of neuropsychiatric function

(2019) Sujin Kim et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Comparative study of testosterone and vitamin D analogue, elocalcitol, on insulin-controlled signal transduction pathway regulation in human skeletal muscle cells

(2019) C. Antinozzi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Signals from the Niche: Insights into the Role of IGF-1 and IL-6 in Modulating Skeletal Muscle Fibrosis

(2019) Laura Forcina et al.   Cells

Role of Myokines in Regulating Skeletal Muscle Mass and Function

(2019) Jong Han Lee et al.   Frontiers in Physiology

Lifelong aerobic exercise protects against inflammaging and cancer

(2019) Mats I. Nilsson et al.   PLoS One

Role of myokines in the development of skeletal muscle insulin resistance and related metabolic defects in type 2 diabetes

(2019) L. Garneau et al.   DIABETES & METABOLISM

Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study

(2019) M Kyla Shea et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myokines in metabolic homeostasis and diabetes

(2019) Jürgen Eckel   DIABETOLOGIA

Geroprotectors: A role in the treatment of frailty

(2019) A.U. Trendelenburg et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

(2019) Zuo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies

(2019) Dina C. Simes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

If my muscle could talk: Myokines as a biomarker of frailty

(2019) Hélio J. Coelho-Junior et al.   EXPERIMENTAL GERONTOLOGY

Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment

(2018) Francesco Landi et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Effects of Vitamin D on Skeletal Muscle and Athletic Performance

(2018) Geoffrey D. Abrams et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice

(2018) Elisa Benetti et al.   PLoS One

Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy

(2018) Mitsutaka Yakabe et al.   PLoS One

Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan

(2018) John P. Campbell et al.   Frontiers in Immunology

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

(2018) David A. Hood et al.   Annual Review of Physiology

Age-related changes in skeletal muscle: changes to life-style as a therapy

(2018) Rachel McCormick et al.   BIOGERONTOLOGY

Impaired proteostasis during skeletal muscle aging

(2018) Raquel Fernando et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise

(2018) Anna Picca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The controversial role of vitamin D as an antioxidant: results from randomised controlled trials

(2018) Sara Tagliaferri et al.   NUTRITION RESEARCH REVIEWS

The compelling link between physical activity and the body's defense system

(2018) David C. Nieman et al.   Journal of Sport and Health Science

Potential role for the VDR agonist elocalcitol in metabolic control: Evidences in human skeletal muscle cells

(2017) Cristina Antinozzi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview – the SENATOR Project ONTOP Series

(2017) Isabel Lozano-Montoya et al.   Clinical Interventions in Aging

Role of muscle IL-6 in gender-specific metabolism in mice

(2017) Amalia Molinero et al.   PLoS One

Exercise Promotes Healthy Aging of Skeletal Muscle

(2016) Gregory D. Cartee et al.   Cell Metabolism

Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study

(2016) Julianne D. van der Berg et al.   DIABETOLOGIA

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

(2016) Mark E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Inflammaging and Skeletal Muscle: Can Protein Intake Make a Difference?

(2016) Dimitrios Draganidis et al.   JOURNAL OF NUTRITION

Role of reactive oxygen species in age-related neuromuscular deficits

(2016) Malcolm J. Jackson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise

(2015) Gregory D. Cartee   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

(2015) Paola Lucia Minciullo et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes

(2015) Naohiko HAYAKAWA et al.   BIOMEDICAL RESEARCH-TOKYO

Relationship of anabolic and catabolic biomarkers with muscle strength and physical performance in older adults: a population-based cross-sectional study

(2015) Yongxia Meng et al.   BMC MUSCULOSKELETAL DISORDERS

Sarcopenia as the Biological Substrate of Physical Frailty

(2015) Francesco Landi et al.   CLINICS IN GERIATRIC MEDICINE

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans

(2015) Dale Morrison et al.   FREE RADICAL BIOLOGY AND MEDICINE

FOXO1 Mediates Vitamin D Deficiency-Induced Insulin Resistance in Skeletal Muscle

(2015) Songcang Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In vivolevels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice

(2014) Angela Logan et al.   AGING CELL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes

(2014) Bart B. L. Groen et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Effects of Vitamin D on Skeletal Muscle Strength, Muscle Mass, and Muscle Power: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2014) Charlotte Beaudart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training

(2014) G. Paulsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vitamin D Receptor Agonists: Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy

(2014) Clara Crescioli   Biomed Research International

Mitochondrial energetics is impairedin vivoin aged skeletal muscle

(2013) Gilles Gouspillou et al.   AGING CELL

Secretome profiling of primary human skeletal muscle cells

(2013) Sonja Hartwig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity

(2013) Christian M. Girgis et al.   CLINICAL ENDOCRINOLOGY

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

(2013) Mats I. Nilsson et al.   FASEB JOURNAL

Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

(2013) Pura Muñoz-Cánoves et al.   FEBS Journal

Protective effect of whey protein hydrolysates on H2O2-induced PC12 cells oxidative stress via a mitochondria-mediated pathway

(2013) Man-Man Jin et al.   FOOD CHEMISTRY

Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases

(2013) G. K. Sakellariou et al.   FREE RADICAL RESEARCH

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

(2013) Emanuele Marzetti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

(2013) Marco Sandri   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise

(2013) Todd A. Trappe et al.   JOURNAL OF APPLIED PHYSIOLOGY

Vitamin D Receptor Inhibits Nuclear Factor κB Activation by Interacting with IκB Kinase β Protein

(2013) Yunzi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D, Mitochondria, and Muscle

(2013) Roger Bouillon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

(2013) Nigel Turner et al.   JOURNAL OF ENDOCRINOLOGY

Vitamin D Receptor Agonists Target CXCL10: New Therapeutic Tools for Resolution of Inflammation

(2013) Sabino Scolletta et al.   MEDIATORS OF INFLAMMATION

The Vitamin D Receptor Agonist BXL-01-0029 as a Potential New Pharmacological Tool for the Treatment of Inflammatory Myopathies

(2013) Luigi Di Luigi et al.   PLoS One

Vitamin C administration attenuates overload-induced skeletal muscle hypertrophy in rats

(2012) Y. Makanae et al.   Acta Physiologica

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Studies of Mitochondrial and Nonmitochondrial Sources Implicate Nicotinamide Adenine Dinucleotide Phosphate Oxidase(s) in the Increased Skeletal Muscle Superoxide Generation That Occurs During Contractile Activity

(2012) Giorgos Konstantinos Sakellariou et al.   ANTIOXIDANTS & REDOX SIGNALING

Cultured senescent myoblasts derived from human vastus lateralis exhibit normal mitochondrial ATP synthesis capacities with correlating concomitant ROS production while whole cell ATP production is decreased

(2012) Ariane D. Minet et al.   BIOGERONTOLOGY

Vitamin D and Its Role in Skeletal Muscle

(2012) Lisa Ceglia et al.   CALCIFIED TISSUE INTERNATIONAL

Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males

(2012) Donato A. Rivas et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Muscle-to-organ cross talk mediated by myokines

(2012) Line Pedersen et al.   Adipocyte

Acute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal women

(2011) Sebely Pal et al.   BRITISH JOURNAL OF NUTRITION

Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance

(2011) S. Ghosh et al.   DIABETES

The role of ubiquitin–proteasome system in ageing

(2011) Peter Löw   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity

(2011) Darcy L. Johannsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats

(2011) Hossam Ebaid et al.   Lipids in Health and Disease

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes: The Korean Sarcopenic Obesity Study (KSOS)

(2010) T. N. Kim et al.   DIABETES CARE

Low-intensity physical activity is associated with reduced risk of incident type 2 diabetes in older adults: evidence from the English Longitudinal Study of Ageing

(2010) P. Demakakos et al.   DIABETOLOGIA

Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells

(2010) Costanza Sagrinati et al.   TRANSPLANT INTERNATIONAL

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

(2009) Emilie A Wilkes et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Longitudinal study of muscle strength, quality, and adipose tissue infiltration

(2009) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins

(2009) Kari E. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

(2009) Emanuele Marzetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes

(2009) S. W. Park et al.   DIABETES CARE

Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength

(2009) L. A. Schaap et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Chronic Effects of Whey Proteins on Blood Pressure, Vascular Function, and Inflammatory Markers in Overweight Individuals

(2009) Sebely Pal et al.   Obesity

Effect of dietary protein content during recovery from high-intensity cycling on subsequent performance and markers of stress, inflammation, and muscle damage in well-trained men

(2008) David S. Rowlands et al.   Applied Physiology Nutrition and Metabolism

Elocalcitol Inhibits Inflammatory Responses in Human Thyroid Cells and T Cells

(2008) E. Borgogni et al.   ENDOCRINOLOGY

Immunomodulatory effects of BXL-01-0029, a less hypercalcemic vitamin D analogue, in human cardiomyocytes and T cells

(2008) M. Sottili et al.   EXPERIMENTAL CELL RESEARCH

Nuclear factor-kappa B signaling in skeletal muscle atrophy

(2008) Hong Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM