Article
Biochemistry & Molecular Biology
Sameh A. Ahmed, Yaser M. Alahmadi, Yasser A. Abdou
Summary: This study aimed to assess the levels of individual reactive oxygen species (ROS) and reactive nitrogen species (RNS) in COVID-19 patients and clarify their usefulness as potential disease severity biomarkers for the first time. The results showed significantly higher levels of individual ROS and RNS in the sera of COVID-19 patients compared to healthy subjects, with significant positive correlations with biochemical markers. Furthermore, significantly elevated levels of ROS and RNS were observed in intensive care unit (ICU) patients compared with non-ICU patients. Therefore, serum ROS and RNS concentrations can be used as biomarkers to track the prognosis of COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Xiao-Yan Chen, Ko Ling Chan, Camilla K. M. Lo, Frederick K. Ho, Wing Cheong Leung, Patrick Ip
Summary: This meta-analysis examined the association between childhood and adulthood victimization and inflammation, highlighting a significant positive correlation. The effect size was found to be small, with childhood victimization showing a stronger effect on inflammation compared to adulthood victimization. Prevention of childhood victimization may be necessary to reduce inflammatory responses.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Nadine Biesemann, Daniel Margerie, Christian Asbrand, Markus Rehberg, Virginia Savova, Inoncent Agueusop, Daniel Klemmer, Danping Ding-Pfennigdorff, Uwe Schwahn, Markus Dudek, Karen Heyninck, Evelyn De Tavernier, Sigrid Cornelis, Markus Kohlmann, Frank O. Nestle, Matthias Herrmann
Summary: The study found that inhibiting both TNF and IL-6 is effective in treating rheumatoid arthritis (RA). Single-cell RNA sequencing of RA patients revealed the synergistic effect of TNF and IL-6 on disease mechanisms and biomarkers. In mouse models, combining anti-TNF and anti-IL-6 antibodies resulted in sustained remission, improved histology, and effects on bone remodeling pathways.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Kentaro Hayashi, Hideaki Shibata, Azusa Oita, Kazuya Nishina, Akihiko Ito, Kiwamu Katagiri, Junko Shindo, Wilfried Winiwarter
Summary: The artificial fixation of reactive nitrogen has huge benefits but also poses substantial threats to human and ecosystem health. National N-budget approach helps grasp the whole picture of Nr loss, and the study in Japan shows decreasing trends in Nr loss to the environment, particularly in atmospheric emissions and terrestrial water loss. Future challenges lie in further reducing N waste and adapting N flows in international trade to adopt more sustainable options considering the reduced demand due to the aging population.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Ana Claudia Lima, Diana Amorim, Ines Laranjeira, Armando Almeida, Rui L. Reis, Helena Ferreira, Filipa Pinto-Ribeiro, Nuno M. Neves
Summary: The immobilization of anti-TNF-α and anti-IL-6 antibodies on polymeric nanoparticles extended and increased therapeutic efficacy while avoiding off-target effects. Biofunctionalized nanoparticles showed greater efficiency in reducing inflammation compared to soluble antibodies, offering a promising therapeutic option for inflammatory conditions with a safe profile and prolonged action.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Wanvisa Udomsinprasert, Jiraphun Jittikoon, Sermsiri Sangroongruangsri, Usa Chaikledkaew
Summary: The levels of IL-6 and IL-10 in COVID-19 patients may serve as potential biomarkers for disease severity and mortality.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Plant Sciences
Ashim Kumar Das, Touhidur Rahman Anik, Md. Mezanur Rahman, Sanjida Sultana Keya, Md. Robyul Islam, Md. Abiar Rahman, Sharmin Sultana, Protik Kumar Ghosh, Sabia Khan, Tofayel Ahamed, Totan Kumar Ghosh, Lam Son-Phan Tran, Mohammad Golam Mostofa
Summary: Soil salinity is a major environmental concern that significantly reduces plant growth and production worldwide. This study has shown that the priming of soybean plants with exogenous ethanol can enhance their growth performance and alleviate the negative effects of salinity by enhancing antioxidant mechanisms and maintaining osmotic adjustment. Furthermore, ethanol treatment can promote the uptake and partitioning of K+ and Mg2+ in salt-stressed plants, ultimately increasing soybean production in salt-affected areas.
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Article
Geriatrics & Gerontology
Betty Manrique-Espinoza, Rosa Palazuelos-Gonzalez, Victoria Pando-Robles, Oscar Rosas-Carrasco, Aaron Salinas-Rodriguez
Summary: This study analyzed the association between tumor necrosis factor-alpha (TNF-alpha), Interleukin-10 (IL-10), C-reactive protein (CRP) and physical performance in a sample of older adults in rural Mexico. The results showed a significant association between higher CRP levels and low physical performance, while IL-10 and TNF-alpha did not show a significant association.
Article
Allergy
Shakiba Kazemian, Reza Ahmadi, Ali Rafiei, Fatemeh Azadegan-Dehkordi, Arsalan Khaledifar, Meghdad Abdollahpour-Alitappeh, Nader Bagheri
Summary: This study found higher serum levels of IL-36 in patients with coronary artery disease (CAD) and their association with the serum levels of tumor necrosis factor (TNF)-alpha, IL-6, and IL-32. The high levels of IL-36 may play a key role in the pathogenesis of CAD.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Review
Immunology
Joshua H. Cho, Saumya Bhutani, Carole H. Kim, Michael R. Irwin
Summary: This review examined the potential of exogenous melatonin in reducing inflammatory markers in humans. Results showed significant anti-inflammatory effects of melatonin on certain markers, suggesting its potential as a preventative and adjunct treatment for inflammatory disorders in older populations.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Food Science & Technology
Shanshan Hou, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Qiuhua Ji, Zhiying Fan, Zhihao Liu, Meitong Liu, Yan Yang
Summary: This meta-analysis examines the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators. The results show that CoQ10 can significantly reduce the levels of circulating CRP, IL-6, and TNF-a, and increase the concentration of circulating CoQ10. Daily supplementation of 300-400 mg CoQ10 is recommended for superior inhibition of inflammatory factors.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mitra Hariri, Bahareh Amirkalali, Hamid Reza Baradaran, Ali Gholami
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of parenteral selenium on inflammatory markers. The results revealed that parenteral selenium supplementation significantly reduced serum IL-6 levels but did not have a significant effect on CRP levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pediatrics
Michael Wagner, Tobias Werther, Ewald Unger, Gregor Kasprian, Gregor Dovjak, Christian Dorfer, Hannah Schned, Philipp Steinbauer, Katharina Goeral, Monika Olischar, Karl Roessler, Angelika Berger, Gunpreet Oberoi
Summary: This pilot study developed realistic neonatal brain models, including the ventricular system, using multimodality imaging. MRI and 3D ultrasound were found to be comparable in deriving anatomical information of the neonatal brain. Further research on dimensional correlations is needed to establish 3D ultrasound as a standard for producing high-quality 3D printed models.
PEDIATRIC RESEARCH
(2022)
Review
Rehabilitation
Julia (Shi-Peng) Xiong, Sarah E. Reedman, Michelle E. Kho, Brian W. Timmons, Olaf Verschuren, Jan Willem Gorter
Summary: This study aimed to explore the operationalization and measurement of sedentary behavior in individuals with cerebral palsy. Results showed that sitting and lying are considered sedentary postures in individuals with CP, defined as <= 1.5 METs. There is variability in the tools used to measure SB in this population, highlighting the need for consensus on the definition and reporting of sedentary behavior.
DISABILITY AND REHABILITATION
(2022)
Article
Otorhinolaryngology
Yavor Bozhkov, Julia Shawarba, Julian Feulner, Fabian Winter, Stefan Rampp, Ullrich Hoppe, Arnd Doerfler, Heinrich Iro, Michael Buchfelder, Karl Roessler
Summary: Surgery for small vestibular schwannomas can achieve excellent hearing preservation. Different grading systems have a significant impact on and correlate with postoperative hearing preservation. Tumor size appears to be more important than anatomical relationships.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, General & Internal
Fabian Winter, Celia M. Markert, Maximilian Krawagna, Michael Buchfelder, Karl Roessler
Summary: This study compared radiological parameters and clinical outcomes between patients younger than 65 years and those over 65 years of age with cerebral aneurysms. It found that the Glasgow outcome scale was significantly lower in the older group after clipping of ruptured aneurysms, but not significantly different after clipping of unruptured aneurysms.
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Article
Oncology
Gilbert Hangel, Philipp Lazen, Sukrit Sharma, Barbara Hristoska, Cornelius Cadrien, Julia Furtner, Ivo Rausch, Alexandra Lipka, Eva Niess, Lukas Hingerl, Stanislav Motyka, Stephan Gruber, Bernhard Strasser, Barbara Kiesel, Matthias Preusser, Thomas Roetzer-Pejrimovsky, Adelheid Woehrer, Wolfgang Bogner, Georg Widhalm, Karl Roessler, Tatjana Traub-Weidinger, Siegfried Trattnig
Summary: This study compared the application of 7T magnetic resonance spectroscopic imaging (MRSI) with amino acid positron emission tomography (PET) in glioma patients. The results showed that the ratios of glutamine and glycine in MRSI had better correspondence to PET signals, while the commonly used choline did not.
Article
Clinical Neurology
F. Winter, L. Boehm, J. Shawarba, K. Callegari, M. Buchfelder, K. Roessler
Summary: This study retrospectively analyzed the data of 40 patients with cdAVF/sdAVF and found that microsurgery resulted in complete occlusion in most cases of sdAVFs, but additional endovascular treatment was necessary in nearly 50% of patients with cdAVF.
NEUROLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Matthias Tomschik, Dominik Wiedner, Johannes Herta, Jonathan Wais, Fabian Winter, Karl Roessler, Christian Dorfer
Summary: The use of non-steroidal anti-inflammatory drugs (NSAIDs) does not increase the recurrence rates of chronic subdural hematoma (cSDH), while male sex is identified as a risk factor for cSDH recurrence.
JOURNAL OF NEUROSURGICAL SCIENCES
(2023)
Article
Pediatrics
Mila Bjelica, Rachel G. Walker, Joyce Obeid, Robert M. Issenman, Brian W. Timmons
Summary: This study aimed to assess the feasibility, safety, participant satisfaction, and efficacy of a training program for youth with IBD. The results showed that supervised exercise training is feasible, safe, and effective for youth with IBD and should be encouraged.
PEDIATRIC EXERCISE SCIENCE
(2023)
Article
Oncology
Olga Ciobanu-Caraus, Thomas Czech, Andreas Peyrl, Christine Haberler, Gregor Kasprian, Julia Furtner, Marcel Kool, Martin Sill, Josa M. Frischer, Anna Cho, Irene Slavc, Karl Roessler, Johannes Gojo, Christian Dorfer
Summary: This study investigated the correlation between intraoperative observation of the site of origin and molecular subtypes of medulloblastoma (MB). The results showed that intraoperative observation had limited predictive value for determining the molecular subtype. Therefore, maximal safe resection should remain the aim of surgery.
Article
Pediatrics
Bhanu Sharma, Joyce Obeid, Carol Dematteo, Michael D. Noseworthy, Brian W. Timmons
Summary: The study aimed to quantify accelerometer-measured physical activity and sedentary time in children with concussion and healthy controls. The findings revealed that children with concussion were less active and spent more time being sedentary, especially female participants.
PEDIATRIC EXERCISE SCIENCE
(2023)
Article
Medicine, General & Internal
Farjad Khalaveh, Mario Mischkulnig, Vitalij Zeiser, Matthias G. Vossen, Andrea Reinprecht, Christian Dorfer, Karl Roessler, Johannes Herta
Summary: This study demonstrates that CSF parameters collected from the EVD collection bag can be reliably assessed, reducing manipulation at the proximal port and minimizing the risk of infection.
Article
Clinical Neurology
Dorian Hirschmann, Thomas Czech, Karl Roessler, Paul Krachsberger, Shivam Paliwal, Olga Ciobanu-Caraus, Anna Cho, Andreas Peyrl, Martha Feucht, Josa Maria Frischer, Christian Dorfer
Summary: The objective of this study is to provide a treatment algorithm for pediatric patients with intracranial cavernous malformations (CMs) based on the authors' experience. The study retrospectively evaluated pediatric patients under the age of 18 who were treated either surgically or conservatively between 1982 and 2019. The results showed that surgical treatment was associated with larger lesions and higher seizure prevalence in patients with lobar CMs, while a more aggressive approach was associated with higher modified Rankin scale scores in patients with deep CMs. The study suggests a treatment algorithm based on lesion location and size, symptom burden, epilepsy workup, and clinical course.
NEUROSURGICAL REVIEW
(2022)
Article
Psychology, Developmental
Maeghan E. James, Sara King-Dowling, Jeffrey D. Graham, Cheryl Missiuna, Brian W. Timmons, John Cairney
Summary: While DCD did not have a negative impact on MVPA, after adjusting for ADHD symptoms, the effect of DCD became significant, driven primarily by symptoms of inattention. Symptoms of ADHD may be suppressing the negative effects of DCD on MVPA, underlining the importance of assessing and controlling for ADHD symptoms in this population.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Public, Environmental & Occupational Health
Monika Szpunar, Andrew M. Johnson, Molly Driediger, Shauna M. Burke, Jennifer D. Irwin, Jacob Shelley, Brian W. Timmons, Leigh M. Vanderloo, Patricia Tucker
Summary: The study tested the implementation of a childcare physical activity policy and found varying levels of adherence to policy items. Effective communication was key to successful policy implementation, but some educators were not likely to continue with more frequent outdoor activities.
HEALTH EDUCATION & BEHAVIOR
(2022)
Article
Education & Educational Research
Brianne A. Bruijns, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Jennifer D. Irwin, Patti-Jean Naylor, Brian W. Timmons, Leigh M. Vanderloo, Patricia Tucker
Summary: Educators play a significant role in shaping children's behaviors, and this study explores how their perspectives on physical activity and screen-viewing influence their provision of these activities in childcare. The findings highlight the importance of PA-related training and personal PA habits in positively influencing ECE candidates' values and perceptions of their role in promoting PA in childcare. Most candidates also express an interest in further PA/SV training.
JOURNAL OF EARLY CHILDHOOD TEACHER EDUCATION
(2022)