Review
Biochemistry & Molecular Biology
Xing Wang, Danping Fan, Xiaoxue Cao, Qinbin Ye, Qiong Wang, Mengxiao Zhang, Cheng Xiao
Summary: This article examines the functions of reactive oxygen species (ROS) and related molecular mechanisms in the synovial microenvironment of rheumatoid arthritis (RA) and reviews strategies for treating RA by regulating ROS.
Article
Materials Science, Multidisciplinary
Sen Lin, Dahao Wang, Chang Xu, Peng Zhang, Kai Gao, Chang Liu, Xifan Mei
Summary: In this study, folic acid modified celastrol-loaded nanoparticles were developed, which can release RA symptoms and have validated anti-inflammatory effects. These nanoparticles modify the polarization of macrophages and significantly reduce inflammation levels in serum and joints.
MATERIALS & DESIGN
(2022)
Review
Immunology
Weiji Lin, Pan Shen, Yaqin Song, Ying Huang, Shenghao Tu
Summary: ROS plays a crucial role in preventing abnormal autoimmunity and may be necessary in some cases, such as in a mouse model of rheumatoid arthritis. It acts as a mediator between innate and adaptive immune cells, influencing T cell activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Review
Immunology
Weiyao Jing, Cui Liu, Chenghong Su, Limei Liu, Ping Chen, Xiangjun Li, Xinghua Zhang, Bo Yuan, Haidong Wang, Xiaozheng Du
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone and cartilage damage. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which upregulate inflammatory pathways and contribute to angiogenesis and bone destruction, thereby accelerating RA progression. This review highlights the effects of ROS accumulation and mitochondrial damage on inflammation, angiogenesis, and bone and cartilage damage in RA, as well as discusses therapeutic approaches targeting ROS or mitochondria to alleviate symptoms and the current gaps and controversies in research.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Naoki Kondo, Tomotake Kanai, Masayasu Okada
Summary: This paper outlines the pathogenesis of rheumatoid arthritis (RA) and the involvement of oxidative stress. It provides evidence of the association between oxidative stress and RA, and describes various therapeutic targets for improving disease activity and oxidative state in RA. Furthermore, it reviews the association of natural foods, phytochemicals, chemical compounds with antioxidant properties, and the microbiota with RA pathogenesis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yan Zhu, Tianjiao Zhao, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Qiong Huang, Kelong Ai
Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.
Review
Chemistry, Multidisciplinary
Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong-Wei Wang, Nicholas Ws Chew, Kian-Keong Poh, Ru-San Tan, Tuck Wah Soong, Yunlu Dai, Lei Ye, Xiaoyuan Chen
Summary: Ischemic heart disease (IHD) is a leading cause of disability and death worldwide. Reactive oxygen species (ROS) play a key role in the progression of diabetes, hypertension, and hypercholesterolemia, which are independent risk factors for atherosclerosis and the development of IHD. Nanomedicines, as smart and multifunctional nanocarriers, are being extensively studied and explored for their synergistic therapeutic effects.
ADVANCED MATERIALS
(2022)
Article
Engineering, Environmental
Meng-Wen Ma, Kai-Lin He, Chao-Qing Li, Xiao-Ting Xie, Sui Zhou, Bin Zhang, Xiao-Lin Hou, Cheng Li, Yuan-Di Zhao, Ling-Li Dong, Bo Liu
Summary: In this study, hyaluronic acid-modified platinum-tellurium nanorods (HPT) were synthesized as a targeted therapy for rheumatoid arthritis (RA). HPT effectively removed inflammatory macrophages and reactive oxygen species (ROS), alleviating the inflammatory response and bone erosion. Animal experiments showed a significant reduction in clinical scores and bone erosion in mice treated with HPT and laser irradiation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Medicine, General & Internal
Seonyoung Kang, Kyungdo Han, Jin-Hyung Jung, Yeonghee Eun, In Young Kim, Jiwon Hwang, Eun-Mi Koh, Seulkee Lee, Hoon-Suk Cha, Hyungjin Kim, Jaejoon Lee
Summary: This large-scale nationwide cohort study investigated the association between cardiovascular disease (CVD) risk and rheumatoid arthritis (RA) and factors that may increase CVD risk. The study found that RA patients had a 50% higher risk of myocardial infarction (MI) and a 20% higher risk of stroke. The association between RA and CVD was more prominent in females, and the association between RA and MI risk was significant in individuals without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Benedicte Delcoigne, Sella A. Provan, Eirik K. Kristianslund, Johan Askling, Lotta Ljung
Summary: This study aimed to estimate the short-term risks of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) based on their current disease activity, including remission. The results showed that failure to reach remission is associated with an increased risk of ACS, highlighting the importance of optimizing cardiovascular risk factors in these patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Heidi Kokkonen, Linda Johansson, Hans Stenlund, Solbritt Rantapaa-Dahlqvist
Summary: The increased comorbidity and mortality in rheumatoid arthritis (RA) patients are largely due to cardiovascular disease (CVD). Risk factors for CVD present in pre-RA individuals were associated with future cardiovascular events, and even after adjustments for these risk factors and treatments after RA onset, pre-RA individuals had a higher risk of cardiovascular events compared with controls.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jeneen Panezai, Ambereen Ghaffar, Mohammad Altamash, Mikael Aberg, Thomas E. Van Dyke, Anders Larsson, Per-Erik Engstrom
Summary: Periodontal disease enhances the expression of CVD-related biomarkers in RA patients through shared pathological clusters, concurrently enhancing metabolic and skeletal disease protein interactions, independent of autoimmune status.
Article
Biochemistry & Molecular Biology
Su-Jin Yoo, Ha-Reum Lee, Jinhyun Kim, In Seol Yoo, Chan Keol Park, Seong Wook Kang
Summary: This study reveals the high expression of CD70 on fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients, which is induced by IL-17 and TNF-alpha. The surface expression of CD70 is regulated by HIF-2 alpha and ROS levels and plays a crucial role in cell migration in RA FLS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Tate M. Johnson, Harlan R. Sayles, Joshua F. Baker, Michael D. George, Punyasha Roul, Cheng Zheng, Brian Sauer, Katherine P. Liao, Daniel R. Anderson, Ted R. Mikuls, Bryant R. England
Summary: In patients with RA, the use of MTX was associated with a reduced risk of cardiovascular events, particularly HF-related hospitalizations. However, this association was not mediated through reductions in RA disease activity, suggesting that MTX may modify CVD risk in this population through alternative mechanisms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
