The long search for a serotype independent pneumococcal vaccine

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV-15) compared to PCV-13 in healthy older adults

(2019) Helen L. Stacey et al.   Human Vaccines & Immunotherapeutics

A dose ranging study of 2 different formulations of 15-valent pneumococcal conjugate vaccine (PCV15) in healthy infants

(2019) R. Rupp et al.   Human Vaccines & Immunotherapeutics

Herd immunity alters the conditions for performing dose schedule comparisons: an individual-based model of pneumococcal carriage

(2019) Alan Yang et al.   BMC INFECTIOUS DISEASES

Host-Pathogen Interactions in Gram-Positive Bacterial Pneumonia

(2019) Jennifer A. Grousd et al.   CLINICAL MICROBIOLOGY REVIEWS

Progress in mucosal immunization for protection against pneumococcal pneumonia

(2019) Viviane Maimoni Gonçalves et al.   Expert Review of Vaccines

Effect of a pneumococcal whole cell vaccine on influenza A-induced pneumococcal otitis media in infant mice

(2019) Jayne Manning et al.   VACCINE

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

(2019) Shahan Syed et al.   Frontiers in Cellular and Infection Microbiology

New insights into the pathogenesis of Streptococcus pneumoniae–associated hemolytic uremic syndrome

(2019) Rebecca R. Scobell et al.   PEDIATRIC NEPHROLOGY

Phase 1 trial of a 20-valent pneumococcal conjugate vaccine in healthy adults

(2019) Allison Thompson et al.   VACCINE

Efficacy, safety and immunogenicity of a pneumococcal protein-based vaccine co-administered with 13-valent pneumococcal conjugate vaccine against acute otitis media in young children: A phase IIb randomized study

(2019) Laura L. Hammitt et al.   VACCINE

Streptococcus pneumoniae: transmission, colonization and invasion

(2018) Jeffrey N. Weiser et al.   NATURE REVIEWS MICROBIOLOGY

Childhood community-acquired pneumonia: A review of etiology- and antimicrobial treatment studies

(2018) Gerdien A. Tramper-Stranders   Paediatric Respiratory Reviews

Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection

(2018) Tasson C. Rodrigues et al.   PLoS One

Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15

(2018) Brian Wahl et al.   Lancet Global Health

A pneumococcal vaccine combination with two proteins containing PspA families 1 and 2 can potentially protect against a wide range of Streptococcus pneumoniae strains

(2018) Jinfei Yu et al.   IMMUNOLOGIC RESEARCH

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV15) in healthy infants

(2018) David Greenberg et al.   VACCINE

Engineering a Next-Generation Glycoconjugate-Like Streptococcus pneumoniae Vaccine

(2018) Andrew B. Hill et al.   ACS Infectious Diseases

Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection

(2018) Kosuke Nagai et al.   VACCINE

Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies

(2018) Philipp Janesch et al.   Virulence

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

(2018) Joseph J Campo et al.   eLife

Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation

(2018) Franziska Voß et al.   Frontiers in Immunology

A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13

(2018) Mark Reglinski et al.   npj Vaccines

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

(2017) Michael E. Pichichero   Expert Review of Vaccines

Rational selection of broadly cross-reactive family 2 PspA molecules for inclusion in chimeric pneumococcal vaccines

(2017) T.R. Converso et al.   MICROBIAL PATHOGENESIS

Systemic immunization with rPotD reduces Streptococcus pneumoniae nasopharyngeal colonization in mice

(2017) T.R. Converso et al.   VACCINE

Recombinant BCG expressing a PspA-PdT fusion protein protects mice against pneumococcal lethal challenge in a prime-boost strategy

(2017) Cibelly Goulart et al.   VACCINE

A protein chimera including PspA in fusion with PotD is protective against invasive pneumococcal infection and reduces nasopharyngeal colonization in mice

(2017) T.R. Converso et al.   VACCINE

The scope for pneumococcal vaccines that do not prevent transmission

(2017) Stefan Flasche   VACCINE

Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study

(2017) Aderonke Odutola et al.   VACCINE

Safety and immunogenicity of a novel multiple antigen pneumococcal vaccine in adults: A Phase 1 randomised clinical trial

(2017) Claire Entwisle et al.   VACCINE

Non-encapsulated Streptococcus pneumoniae, vaccination as a measure to interfere with horizontal gene transfer

(2017) J. D. Langereis et al.   Virulence

Molecular characterization of pneumococcal surface protein K, a potential pneumococcal vaccine antigen

(2017) A-Yeung Jang et al.   Virulence

Community acquired pneumonia in children

(2017) Iram J Haq et al.   BMJ-British Medical Journal

Advances in the causes and management of community acquired pneumonia in adults

(2017) Richard G Wunderink et al.   BMJ-British Medical Journal

Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens

(2017) Robert Wilson et al.   PLoS Pathogens

The immunological mechanisms that control pneumococcal carriage

(2017) Simon P. Jochems et al.   PLoS Pathogens

Community acquired pneumonia in children

(2017) Iram J Haq et al.   BMJ-British Medical Journal

Advances in the causes and management of community acquired pneumonia in adults

(2017) Richard G Wunderink et al.   BMJ-British Medical Journal

Towards Identifying Protective B-Cell Epitopes: The PspA Story

(2017) Naeem Khan et al.   Frontiers in Microbiology

Comprehensive vaccine design for commensal disease progression

(2017) Charles H. Jones et al.   Science Advances

The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates

(2017) Layla K. Mahdi et al.   EBioMedicine

Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia

(2016) Naomi J. Gadsby et al.   CLINICAL INFECTIOUS DISEASES

Intranasal vaccination with  -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses

(2016) R. Babb et al.   CLINICAL SCIENCE

Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization

(2016) Christopher J. Greene et al.   INFECTION AND IMMUNITY

Ten-Year Study of the Stringently Defined Otitis-prone Child in Rochester, NY

(2016) Michael E. Pichichero   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Directed vaccination against pneumococcal disease

(2016) Yi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Use of Polymerase Chain Reaction Amplification for the Detection of Viruses and Bacteria in Severe Community-Acquired Pneumonia

(2016) Wen Ting Siow et al.   RESPIRATION

Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis

(2016) Bruno Corsini et al.   VACCINE

Nonencapsulated Streptococcus pneumoniae : Emergence and Pathogenesis

(2016) Lance E. Keller et al.   mBio

Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models

(2016) Tania Rivera-Hernandez et al.   mBio

Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen

(2016) Philippe Hermand et al.   Human Vaccines & Immunotherapeutics

Effectiveness of 13-valent pneumococcal conjugate vaccine for prevention of invasive pneumococcal disease in children in the USA: a matched case-control study

(2016) Matthew R Moore et al.   Lancet Respiratory Medicine

Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection

(2015) Austen Chen et al.   Clinical and Vaccine Immunology

Safety, Tolerability and Immunogenicity of 15-valent Pneumococcal Conjugate Vaccine in Toddlers Previously Vaccinated With 7-valent Pneumococcal Conjugate Vaccine

(2015) Ajoke Sobanjo-ter Meulen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Community-acquired pneumonia: An overview

(2015) Lionel A. Mandell   POSTGRADUATE MEDICINE

Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials

(2015) Isabel Leroux-Roels et al.   VACCINE

Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

(2015) W. Abdullah Brooks et al.   VACCINE

Safety, tolerability, and immunogenicity of 15-valent pneumococcal conjugate vaccine in healthy adults

(2015) Richard McFetridge et al.   VACCINE

Rationale and prospects for novel pneumococcal vaccines

(2015) Kristin Moffitt et al.   Human Vaccines & Immunotherapeutics

Evaluation of a Vaccine Formulation against Streptococcus pneumoniae Based on Choline-Binding Proteins

(2014) Eliane N. Miyaji et al.   Clinical and Vaccine Immunology

Post HocAnalysis of a Randomized Double-Blind Trial of the Correlation of Functional and Binding Antibody Responses Elicited by 13-Valent and 7-Valent Pneumococcal Conjugate Vaccines and Association with Nasopharyngeal Colonization

(2014) Christine Juergens et al.   Clinical and Vaccine Immunology

Toll-Like Receptor 2-Dependent Protection against Pneumococcal Carriage by Immunization with Lipidated Pneumococcal Proteins

(2014) Kristin Moffitt et al.   INFECTION AND IMMUNITY

Impact of the pneumococcal conjugate vaccine on serotype distribution and susceptibility trends of pediatric non-invasive Streptococcus pneumoniae isolates in Tokai, Japan over a 5-year period

(2014) Hayato Okade et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Population-Based Analysis of Invasive Nontypeable Pneumococci Reveals That Most Have Defective Capsule Synthesis Genes

(2014) In Ho Park et al.   PLoS One

Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage

(2014) Paul V. Licciardi et al.   VACCINE

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study

(2014) Geert Leroux-Roels et al.   VACCINE

Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model

(2014) David Verhoeven et al.   VACCINE

Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial

(2014) Roman Prymula et al.   VACCINE

Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster

(2014) Michael D. Valentino et al.   Nature Communications

Herd protection induced by pneumococcal conjugate vaccine

(2014) Keith P Klugman   Lancet Global Health

Conjugation of Polysaccharide 6B from Streptococcus pneumoniae with Pneumococcal Surface Protein A: PspA Conformation and Its Effect on the Immune Response

(2013) Catia T. Perciani et al.   Clinical and Vaccine Immunology

Comparative Immunogenicity and Efficacy of 13-Valent and 7-Valent Pneumococcal Conjugate Vaccines in Reducing Nasopharyngeal Colonization: A Randomized Double-Blind Trial

(2013) Ron Dagan et al.   CLINICAL INFECTIOUS DISEASES

Current status and perspectives on protein-based pneumococcal vaccines

(2013) Michelle Darrieux et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid–CbpA Peptide Recombinant Fusion Protein

(2013) Beth Mann et al.   JOURNAL OF INFECTIOUS DISEASES

Distinct Distal Gut Microbiome Diversity and Composition in Healthy Children from Bangladesh and the United States

(2013) Audrie Lin et al.   PLoS One

Characterization of Protective Immune Responses Induced by Pneumococcal Surface Protein A in Fusion with Pneumolysin Derivatives

(2013) Cibelly Goulart et al.   PLoS One

A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA

(2013) Sharon E. Frey et al.   VACCINE

Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability

(2013) Viviane M. Gonçalves et al.   VACCINE

Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

(2013) Daniel R. Feikin et al.   PLOS MEDICINE

Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and ColonizationIn VitroandIn Vivo

(2012) Laura R. Marks et al.   INFECTION AND IMMUNITY

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice

(2012) Layla K. Mahdi et al.   JOURNAL OF CLINICAL INVESTIGATION

Protection against pneumococcal infection elicited by immunization with glutamyl tRNA synthetase, polyamine transport protein D and sortase A

(2012) Xun Min et al.   VACCINE

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

(2012) Michael Seiberling et al.   VACCINE

Characterization of Th17 responses to Streptococcus pneumoniae in humans: Comparisons between adults and children in a developed and a developing country

(2012) Anna Lundgren et al.   VACCINE

Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults

(2012) Thierry Kamtchoua et al.   VACCINE

High Levels of Genetic Recombination during Nasopharyngeal Carriage and Biofilm Formation in Streptococcus pneumoniae

(2012) L. R. Marks et al.   mBio

Nontypeable Pneumococci Can Be Divided into Multiple cps Types, Including One Type Expressing the Novel Gene pspK

(2012) I. H. Park et al.   mBio

TH17-Based Vaccine Design for Prevention of Streptococcus pneumoniae Colonization

(2011) Kristin L. Moffitt et al.   Cell Host & Microbe

Diagnostic Tests for Agents of Community-Acquired Pneumonia

(2011) John G. Bartlett   CLINICAL INFECTIOUS DISEASES

Intranasal immunization with autolysin (LytA) in mice model induced protection against five prevalent Streptococcus pneumoniae serotypes in China

(2011) Zhu Qing Yuan et al.   IMMUNOLOGIC RESEARCH

RrgB321, a Fusion Protein of the Three Variants of the Pneumococcal Pilus Backbone RrgB, Is ProtectiveIn Vivoand Elicits Opsonic Antibodies

(2011) Carole Harfouche et al.   INFECTION AND IMMUNITY

Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides

(2011) Philippe Denoël et al.   VACCINE

Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae

(2011) Yali Cui et al.   VACCINE

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressing Streptococcus pneumoniae populations

(2011) Monica Moschioni et al.   VACCINE

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

(2010) Y.-J. Lu et al.   Clinical and Vaccine Immunology

Immune Responses to Recombinant Pneumococcal PsaA Antigen Delivered by a Live Attenuated Salmonella Vaccine

(2010) S. Wang et al.   INFECTION AND IMMUNITY

Immunization withSalmonella entericaSerovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge withStreptococcus pneumoniae

(2010) Maneesha Muralinath et al.   INFECTION AND IMMUNITY

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

The Two Variants of the Streptococcus pneumoniae Pilus 1 RrgA Adhesin Retain the Same Function and Elicit Cross-Protection In Vivo

(2010) M. Moschioni et al.   INFECTION AND IMMUNITY

GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

(2010) Ying-Jie Lu et al.   VACCINE

Mucosal Immunization with Polyamine Transport Protein D (PotD) Protects Mice Against Nasopharyngeal Colonization with Streptococcus pneumoniae

(2009) Pratik Shah et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects againstStreptococcus pneumoniaeinfection in the lung

(2009) Maria T. Arévalo et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

PspA Family Fusion Proteins Delivered by Attenuated Salmonella enterica Serovar Typhimurium Extend and Enhance Protection against Streptococcus pneumoniae

(2009) W. Xin et al.   INFECTION AND IMMUNITY

Nasopharyngeal Carriage of Streptococcus pneumoniae in Gambian Infants: A Longitudinal Study

(2008) P. C. Hill et al.   CLINICAL INFECTIOUS DISEASES

Analysis of Type II Secretion of Recombinant Pneumococcal PspA and PspC in a Salmonella enterica Serovar Typhimurium Vaccine with Regulated Delayed Antigen Synthesis

(2008) W. Xin et al.   INFECTION AND IMMUNITY

Nasal Immunization with Lactococcus lactis Expressing the Pneumococcal Protective Protein A Induces Protective Immunity in Mice

(2008) M. Medina et al.   INFECTION AND IMMUNITY

Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice

(2008) Ju Cao et al.   MICROBES AND INFECTION

Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge

(2008) Ivana B. Campos et al.   MICROBES AND INFECTION

A multifaceted role for polyamines in bacterial pathogens

(2008) Pratik Shah et al.   MOLECULAR MICROBIOLOGY

Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA

(2008) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection induced by pneumococcal surface protein A (PspA) is enhanced by conjugation to a Streptococcus pneumoniae capsular polysaccharide

(2008) Fátima C.L. Csordas et al.   VACCINE

Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization

(2008) Ying-Jie Lu et al.   PLoS Pathogens

Streptococcus pneumoniae: proteomics of surface proteins for vaccine development

(2007) C. Morsczeck et al.   CLINICAL MICROBIOLOGY AND INFECTION