Progress in mucosal immunization for protection against pneumococcal pneumonia

Invasive pneumococcal diseases in children and adults before and after introduction of the 10-valent pneumococcal conjugate vaccine into the Austrian national immunization program

(2019) Lukas Richter et al.   PLoS One

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV-15) compared to PCV-13 in healthy older adults

(2019) Helen L. Stacey et al.   Human Vaccines & Immunotherapeutics

Long-term Association of 13-Valent Pneumococcal Conjugate Vaccine Implementation With Rates of Community-Acquired Pneumonia in Children

(2019) Naïm Ouldali et al.   JAMA Pediatrics

A dose ranging study of 2 different formulations of 15-valent pneumococcal conjugate vaccine (PCV15) in healthy infants

(2019) R. Rupp et al.   Human Vaccines & Immunotherapeutics

Intranasal Immunization with Pneumococcal Surface Protein A in the presence of Nanoparticle Forming Polysorbitol Transporter Adjuvant Induces Protective Immunity against the Streptococcus pneumoniae Infection

(2019) Yoon-Chul Kye et al.   Acta Biomaterialia

Serotype and molecular diversity of nasopharyngeal Streptococcus pneumoniae isolates from children before and after vaccination with the ten-valent pneumococcal conjugate vaccine (PCV10) in Ethiopia

(2019) Wondewosen Tsegaye Sime et al.   BMC INFECTIOUS DISEASES

Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study

(2019) Laura L Hammitt et al.   LANCET

Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines – A phase II, randomised, observer-blind study in Gambian infants

(2019) Aderonke Odutola et al.   VACCINE

Evolution of serotypes in bacteremic pneumococcal adult pneumonia in the period 2001–2014, after introduction of the pneumococcal conjugate vaccine in bizkaia (spain)

(2019) Pedro P. España et al.   VACCINE

Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density

(2019) E.L. German et al.   VACCINE

Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study

(2018) Angel Vila-Corcoles et al.   BMC INFECTIOUS DISEASES

Why is the rate of pneumococcal pneumonia declining?

(2018) Carlos M. Luna et al.   CURRENT OPINION IN PULMONARY MEDICINE

Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000–17: a prospective national observational cohort study

(2018) Shamez N Ladhani et al.   LANCET INFECTIOUS DISEASES

Protection elicited by nasal immunization with pneumococcal surface protein A (PspA) adjuvanted with bacterium-like particles against Streptococcus pneumoniae infection in mice

(2018) Bo Li et al.   MICROBIAL PATHOGENESIS

Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection

(2018) Tasson C. Rodrigues et al.   PLoS One

The changing epidemiology of invasive pneumococcal disease after PCV13 vaccination in a country with intermediate vaccination coverage

(2018) Pilar Ciruela et al.   VACCINE

Post hoc analysis of the efficacy of the 13-valent pneumococcal conjugate vaccine against vaccine-type community-acquired pneumonia in at-risk older adults

(2018) José A. Suaya et al.   VACCINE

Effectiveness of the 13-valent pneumococcal conjugate vaccine against adult pneumonia in Italy: a case–control study in a 2-year prospective cohort

(2018) Rosa Prato et al.   BMJ Open

The changing epidemiology of pneumococcal diseases

(2018) Kristina G Hulten   LANCET INFECTIOUS DISEASES

Broad protective immune responses elicited by bacterium-like particle-based intranasal pneumococcal particle vaccine displaying PspA2 and PspA4 fragments

(2018) Jingcai Lu et al.   Human Vaccines & Immunotherapeutics

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination

(2018) Germaine Hanquet et al.   THORAX

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine compared to 13-valent pneumococcal conjugate vaccine in adults ≥65 years of age previously vaccinated with 23-valent pneumococcal polysaccharide vaccine

(2018) James T. Peterson et al.   Human Vaccines & Immunotherapeutics

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

(2018) Joseph J Campo et al.   eLife

Effect of ten-valent pneumococcal conjugate vaccine introduction on pneumococcal carriage in Fiji: results from four annual cross-sectional carriage surveys

(2018) Eileen M Dunne et al.   Lancet Global Health

Nanoparticle Vaccines Against Infectious Diseases

(2018) Rashmirekha Pati et al.   Frontiers in Immunology

The epidemiology of invasive pneumococcal disease in older adults in the post-PCV era. Has there been a herd effect?

(2017) M. CORCORAN et al.   EPIDEMIOLOGY AND INFECTION

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

(2017) Michael E. Pichichero   Expert Review of Vaccines

Impact of the introduction of pneumococcal conjugate vaccination on pneumonia in The Gambia: population-based surveillance and case-control studies

(2017) Grant A Mackenzie et al.   LANCET INFECTIOUS DISEASES

Safety, reactogenicity and immunogenicity of two investigational pneumococcal protein-based vaccines: Results from a randomized phase II study in infants

(2017) Roman Prymula et al.   VACCINE

The impact of 10-valent and 13-valent pneumococcal conjugate vaccines on hospitalization for pneumonia in children: A systematic review and meta-analysis

(2017) Cristiano Alicino et al.   VACCINE

Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study

(2017) Camelia Savulescu et al.   Lancet Respiratory Medicine

Specific Antibody Deficiency: Controversies in Diagnosis and Management

(2017) Elena Perez et al.   Frontiers in Immunology

Effectiveness of pneumococcal vaccines in preventing pneumonia in adults, a systematic review and meta-analyses of observational studies

(2017) Myint Tin Tin Htar et al.   PLoS One

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

(2016) Elizabeth. C. Carroll et al.   IMMUNITY

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage

(2016) E Mitsi et al.   Mucosal Immunology

Nasopharyngeal carriage of Streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the Netherlands

(2016) Astrid A.T.M. Bosch et al.   VACCINE

Efficacy of 23-valent pneumococcal polysaccharide vaccine in preventing community-acquired pneumonia among immunocompetent adults: A systematic review and meta-analysis of randomized trials

(2016) Wen-qi Diao et al.   VACCINE

Efficacy of PPV23 in Preventing Pneumococcal Pneumonia in Adults at Increased Risk – A Systematic Review and Meta-Analysis

(2016) Julia Schiffner-Rohe et al.   PLoS One

Pneumococcal Capsules and Their Types: Past, Present, and Future

(2015) K. Aaron Geno et al.   CLINICAL MICROBIOLOGY REVIEWS

Impact of infant 13-valent pneumococcal conjugate vaccine on serotypes in adult pneumonia

(2015) Chamira Rodrigo et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles

(2015) Nitesh K. Kunda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study

(2015) Pauline A Waight et al.   LANCET INFECTIOUS DISEASES

Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques

(2015) Y Fukuyama et al.   Mucosal Immunology

Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults

(2015) Marc J.M. Bonten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mucosal Immunization with PsaA Protein, Using Chitosan as a Delivery System, Increases Protection Against Acute Otitis Media and Invasive Infection byStreptococcus pneumoniae

(2015) J.-H. Xu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization

(2015) Kirsten Kuipers et al.   VACCINE

Impact of PCV7/PCV13 introduction on community-acquired alveolar pneumonia in children

(2015) David Greenberg et al.   VACCINE

Carriage of Haemophilus influenzae is associated with pneumococcal vaccination in Italian children

(2015) Romina Camilli et al.   VACCINE

Pneumococcal disease prevention among adults: Strategies for the use of pneumococcal vaccines

(2015) Tamara Pilishvili et al.   VACCINE

Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies

(2015) Shujing Wang et al.   Protein & Cell

Impact of Pneumococcal Conjugate Universal Routine Vaccination on Pneumococcal Disease in Italian Children

(2015) Francesca Fortunato et al.   Journal of Immunology Research

Nanoparticle-Mediated Pulmonary Drug Delivery: A Review

(2014) Mukta Paranjpe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal association of infant immunisation with pneumococcal conjugate vaccine on the ecology of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonisation in a rural South African community

(2014) S.A. Nzenze et al.   VACCINE

Controlled Human Infection and Rechallenge withStreptococcus pneumoniaeReveals the Protective Efficacy of Carriage in Healthy Adults

(2013) Daniela M. Ferreira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Conjugation of Polysaccharide 6B from Streptococcus pneumoniae with Pneumococcal Surface Protein A: PspA Conformation and Its Effect on the Immune Response

(2013) Catia T. Perciani et al.   Clinical and Vaccine Immunology

Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae

(2013) Il Gyu Kong et al.   INFECTION AND IMMUNITY

Enhanced protection against pulmonary mycobacterial challenge by chitosan-formulated polyepitope gene vaccine is associated with increased pulmonary secretory IgA and gamma-interferon+T cell responses

(2013) Wenqing Ai et al.   MICROBIOLOGY AND IMMUNOLOGY

A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA

(2013) Sharon E. Frey et al.   VACCINE

Impact of pneumococcal conjugate vaccines on nasopharyngeal carriage and invasive disease among unvaccinated people: Review of evidence on indirect effects

(2013) Stephanie M. Davis et al.   VACCINE

The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis

(2013) B. Henriques-Normark et al.   Cold Spring Harbor Perspectives in Medicine

Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

(2013) Daniel R. Feikin et al.   PLOS MEDICINE

Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung

(2013) Adam K. A. Wright et al.   PLoS Pathogens

Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications

(2013) Natalija Van Braeckel-Budimir et al.   Frontiers in Immunology

Serotype-independent pneumococcal vaccines

(2012) Eliane Namie Miyaji et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The fundamental link between pneumococcal carriage and disease

(2012) Birgit Simell et al.   Expert Review of Vaccines

Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells

(2012) Elizabeth A. Clutterbuck et al.   JOURNAL OF INFECTIOUS DISEASES

Long-Term Effects of Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis

(2012) Judith Spijkerman et al.   PLoS One

Effective protection against secondary pneumococcal pneumonia by oral vaccination with attenuated Salmonella delivering PspA antigen in mice

(2012) Sang-Uk Seo et al.   VACCINE

Human Nasal Challenge with Streptococcus pneumoniae Is Immunising in the Absence of Carriage

(2012) Adam K. A. Wright et al.   PLoS Pathogens

Strategies for intranasal delivery of vaccines

(2012) Mehfuz Zaman et al.   Drug Delivery and Translational Research

Serotype replacement in disease after pneumococcal vaccination

(2011) Daniel M Weinberger et al.   LANCET

Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study

(2011) Elizabeth Miller et al.   LANCET INFECTIOUS DISEASES

Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults

(2011) K. C. Jambo et al.   THORAX

Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule

(2011) Selma P. Wiertsema et al.   VACCINE

Intranasal Vaccination with Chitosan-DNA Nanoparticles Expressing Pneumococcal Surface Antigen A Protects Mice against Nasopharyngeal Colonization byStreptococcus pneumoniae

(2010) Jianghong Xu et al.   Clinical and Vaccine Immunology

Immunization withSalmonella entericaSerovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge withStreptococcus pneumoniae

(2010) Maneesha Muralinath et al.   INFECTION AND IMMUNITY

New Patterns in the Otopathogens Causing Acute Otitis Media Six to Eight Years After Introduction of Pneumococcal Conjugate Vaccine

(2010) Janet R. Casey et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete

(2010) William P. Hanage et al.   Epidemics

Epidemiology and risk factors for Staphylococcus aureuscolonization in children in the post-PCV7 era

(2009) Grace M Lee et al.   BMC INFECTIOUS DISEASES

Efficacy of pneumococcal vaccination in adults: a meta-analysis

(2009) A. Huss et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

(2009) D. M. Ferreira et al.   Clinical and Vaccine Immunology

Potential role for mucosally active vaccines against pneumococcal pneumonia

(2009) Kondwani C. Jambo et al.   TRENDS IN MICROBIOLOGY

Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge

(2008) Ivana B. Campos et al.   MICROBES AND INFECTION

Inhaled delivery of 23-valent pneumococcal polysaccharide vaccine does not result in enhanced pulmonary mucosal immunoglobulin responses

(2008) Stephen B. Gordon et al.   VACCINE