Article
Immunology
Michael E. Pichichero, Timothy J. Chapman, Peter Bajorski
Summary: The study revealed that otitis-prone children are more susceptible to respiratory infections, showing higher rates of pneumonia, acute sinusitis, and influenza compared to non-otitis-prone children. This increased susceptibility was present from 6 months to 5 years of age, indicating the importance of monitoring and managing respiratory infections in otitis-prone children.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Pediatrics
Sara Torretta, Pasquale Capaccio, Ilaria Coro, Samantha Bosis, Maria Elisabetta Pace, Pietro Tosi, Lorenzo Pignataro, Paola Marchisio
Summary: During the COVID-19 pandemic lockdown in Italy, otitis-prone children in Milan showed significant clinical improvement, with a decrease in acute otitis media episodes, otorrhea episodes, and antibiotic treatments when compared to the same period in 2019. Telemedicine assessment played a crucial role in maintaining patient care during the lockdown and led to unexpected positive outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Oren Ziv, Dana Adelson, Reem Sadeh, Sofia Kordeluk, Sabri El-Saied, Eugene Leibovitz, Mordechai Kraus, Daniel Kaplan
Summary: This retrospective cohort study showed that immunization with pneumococcal conjugate vaccines (PCV) significantly reduced the occurrence of recurrent acute otitis media (rAOM) in infants following an early episode of acute otitis media (AOM).
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Correction
Pediatrics
Sara Torretta, Pasquale Capaccio, Ilaria Coro, Samantha Bosis, Maria Elisabetta Pace, Pietro Bosi, Lorenzo Pignataro, Paola Marchisio
Summary: The surname of the co-author mentioned in the article was misspelled.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Eun Hye Lee, Yong-Sung Choi, Jeewon Ryu, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is caused by various factors including infections, anatomo-physiological abnormalities, allergies, and environmental influences. This study highlights the immune responses in otitis media patients, focusing on antibodies and transcription factors produced by B cells, as well as the important functions of B cells in immune defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Sung Soo Kim, Tong In Oh, Dae Woong Kang, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is mainly caused by upper respiratory tract infection and eustachian tube dysfunction. The expression of Toll-like receptors (TLRs) is closely related to the occurrence, recurrence, chronicization, and complications of otitis media, playing an important role in the early response to external antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Francesco Folino, Miriam Fattizzo, Luca Ruggiero, Martina Oriano, Stefano Aliberti, Francesco Blasi, Michele Gaffuri, Paola Marchisio, Sara Torretta
Summary: The study found a higher relative abundance of Dolosigranulum and Corynebacterium genera in the nasopharynx of healthy children compared to children with RAOM, showing a decreasing trend in relative abundance of these two pivotal genera through disease severity. This suggests the need for further research on the role of Dolosigranulum and Corynebacterium in regulating the healthy URT microbiota.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Correction
Medicine, General & Internal
Alexander E. Perl, Giovanni Martinelli, Jorge E. Cortes, Andreas Neubauer, Ellin Berman, Stefania Paolini, Pau Montesinos, Maria R. Baer, Richard A. Larson, Celalettin Ustun, Francesco Fabbiano, Harry P. Erba, Antonio Di Stasi, Robert Stuart, Rebecca Olin, Margaret Kasner, Fabio Ciceri, Wen-Chien Chou, Nikolai Podoltsev, Christian Recher, Hisayuki Yokoyama, Naoko Hosono, Sung-Soo Yoon, Je-Hwan Lee, Timothy Pardee, Amir T. Fathi, Chaofeng Liu, Nahla Hasabou, Xuan Liu, Erkut Bahceci, Mark J. Levis
Summary: The article contains errors in the numbers of patients receiving previous FLT3 inhibitor therapy and requires correction.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Dong Gu Hur, Arwa Kurabi, Hyun Woo Lim, Meghan Spriggs, Kwang Pak, Allen F. Ryan
Summary: The study demonstrates the critical role of macrophages in resolving otitis media, with macrophage genes being significantly regulated during OM and macrophage depletion increasing the duration of middle ear infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Hye Won Lee, Young Eun Chon, Beom Kyung Kim, Terry Cheuk-Fung Yip, Yee-Kit Tse, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Sang Hoon Ahn
Summary: Patients with chronic hepatitis B in the immune-tolerant phase defined by age and HBV-DNA criteria of the AASLD guideline do not have a significant risk of developing hepatocellular carcinoma. Further validation studies are required to confirm these findings and evaluate the long-term prognosis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Pediatrics
Elisa Barbieri, Gloria Porcu, Tianyan Hu, Tanaz Petigara, Francesca Senese, Gian Marco Prandi, Antonio Scamarcia, Luigi Cantarutti, Anna Cantarutti, Carlo Giaquinto
Summary: This study aimed to assess the incidence trends of acute otitis media (AOM) in children following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in Italy. The results showed a significant decrease in AOM incidence rates after the introduction of PCV13, with older children benefiting the most.
Article
Immunology
Wenyan Fan, Hongming Xu, Chenling Shen, Jia Fang, Xiaoyan Li
Summary: Acute and chronic otitis media (AOM and COM) are common middle ear infections that can lead to hearing loss and other complications. Recent research has shown that both macrophages and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway are involved in the immune response to and the resolution of otitis media. However, the specific effects of Nrf2 on macrophages in the transition of AOM to COM are not well understood, and a practical approach to prevent this transition by targeting Nrf2/macrophages has not been established.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Otorhinolaryngology
Nicole Favre, Vijay A. Patel, Michele M. Carr
Summary: This study evaluated the incidence and management of complications related to pediatric acute mastoiditis using data from a national database, finding that children with intracranial complications are more likely to undergo surgical procedures with wide variability in practice patterns, indicating persistent controversies in the management of otitis media complications.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Kyu Hyun Park, Seung-Ah Choe, Ju-Young Shin, Young June Choe
Summary: This study describes the changing patterns of antibiotic use in children with acute otitis media in South Korea. The prescription of amoxicillin has increased while cephalosporin and macrolide use has decreased. Multifaceted approaches are needed to control antimicrobial resistance.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Michael Nieratschker, Markus Haas, Mateo Lucic, Franziska Pichler, Faris F. Brkic, Thomas Parzefall, Dominik Riss, David T. Liu
Summary: This study aimed to identify associations between extreme weather events and the immediate and delayed risks for acute otitis media (AOM)-related emergency department visits (EV). The results showed that prolonged extreme weather conditions, such as temperature, humidity, precipitation, wind speeds, and atmospheric pressure, significantly impacted the risk ratio (RR) for AOM-related EVs. These findings could improve healthcare resource allocation in similar climates and educate patients about the role of environmental factors in AOM.
FRONTIERS IN PUBLIC HEALTH
(2023)