Article
Pediatrics
Georgie Mathew, Anish Sam George, R. V. Deepthi, Winsley Rose, Valsan Philip Verghese, Rosemol Varghese, Balaji Veeraraghavan, Indira Agarwal
Summary: This study reveals the commonly available serotypes and antibiotic susceptibility of pneumococcal infections in children with nephrotic syndrome, providing important insights for prevention and appropriate management of pneumococcal sepsis in resource-limited countries.
PEDIATRIC NEPHROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jing Chen, Siyu Yang, Wanyu Li, Wei Yu, Zhaowei Fan, Mengyao Wang, Zhenyue Feng, Chunyu Tong, Baifen Song, Jinzhu Ma, Yudong Cui
Summary: The study revealed that infection with Streptococcus agalactiae can induce the differentiation of CD4+ T cells into Th17 cells, which highly express IL-17A and play an important role in defending against the bacteria.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nital Sumaria, Stefania Martin, Daniel J. Pennington
Summary: The study demonstrates that constrained Syk activity optimally engages the PI3K-Akt signaling pathway to promote the development of gamma delta(17) cells and maintain the expression of the IL-17 program. Inhibition of PI3K not only hinders the development of gamma delta(17) cells, but also increases the development of a new subset of gamma delta T cells with a type-I IFN gene expression signature.
Article
Multidisciplinary Sciences
Moeed Akbar, Lindsay A. N. Crowe, Michael McLean, Emma Garcia-Melchor, Lucy MacDonald, Kristyn Carter, Umberto G. Fazzi, David Martin, Angus Arthur, James H. Reilly, Iain B. McInnes, Neal L. Millar
Summary: Frozen shoulder is a common fibroproliferative disease with unclear pathophysiological mechanisms, but evidence suggests the involvement of dysregulated immunobiology. IL-17A plays a key role in inflammation and tissue remodeling in frozen shoulder, with potential as a therapeutic target for future management.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Allergy
Jaehwan Kim, Jongmi Lee, Xuan Li, Hyun Soo Lee, Katherine Kim, Vasuma Chaparala, William Murphy, Wei Zhou, Junyue Cao, Michelle A. Lowes, James G. Krueger
Summary: This study characterized the transcriptome of HS T17 cells compared to psoriasis T17 cells and investigated their interactions with immune cell subsets. The results indicate that IL-1 beta-T17 cell cytokine axis is likely a dominant pathway in HS, and the interaction between semimature dendritic cells and T17 cells is increased in HS compared to psoriasis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yutong Jiang, Mingcan Yang, Yanli Zhang, Yefei Huang, Jialing Wu, Ya Xie, Qiujing Wei, Zetao Liao, Jieruo Gu
Summary: Anti-IL-17A therapy can effectively reverse immune cell imbalance in AS patients, specifically altering the distribution of T cell and B cell subsets.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Long Lu, Yangping Wang, Lina Zhou, Yashu Li, Xiaorong Zhang, Xiaohong Hu, Shugui Shi, Weifeng He
Summary: The study found that Vγ4 T cells play a crucial role in ischemic brain tissue damage by providing an early source of IL-17A in stroke. Additionally, CCL20 and IL-1β/IL-23 are deeply involved in amplifying inflammatory responses in the brain tissue.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Kaile Chen, Xiyan Zhang, Yunzhen Tao, Yunzhong Wang, Jian Xue, Changpeng Liu, Shuang Feng, Yongdong Yan, Qinghui Chen, Jianmei Tian, Genming Zhao, Xuejun Shao, Tao Zhang
Summary: This study described the hospitalization of 105 children <5 years of age for IPD in a hospital in Suzhou, China, from 2010 to 2017, and calculated the incidence rate of IPD in Suzhou. Eight different capsular serotypes of pneumococcus were identified in the study.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi
Summary: A study examined the role of IL-17A and its receptors in HSV-1-induced CNS demyelination. The results showed that IL-17A, along with IL-17RA, IL-17RC, and IL-17RD, plays an important role in this process. Both T cells and non-T cells expressing IL-17A contribute to the development of demyelination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong, Ai-Guo Lu
Summary: This study explores the role of IL-17A in colorectal cancer by evaluating its expression in patients and investigating its effects on cancer cells. The findings suggest that IL-17A can induce mitochondrial dysfunction and pyroptosis, promote intracellular ROS accumulation, and stimulate the secretion of inflammatory factors. Additionally, IL-17A can recruit CD8 + T cells to infiltrate tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Rheumatology
Holly L. Rosenzweig, Emily E. Vance, Kofi Asare-Konadu, Kylie Koney, Ellen J. Lee, Atul A. Deodhar, Rouhin Sen, Liron Caplan, Ruth J. Napier
Summary: This study reveals a novel neutrophil-intrinsic role for Card9 in arthritogenic Th17 responses and the pathogenesis of AS. These data provide valuable utility in our future understanding of CARD9-specific mechanisms in spondyloarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Infectious Diseases
Clara Ines Agudelo, Carlos Castaneda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echaniz-Aviles, Samanta Cristine Grassi Almeida, Maria Noemi Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcon, Pamela Araya, Carolina Duarte, Jacqueline Sanchez, Mirna Novas, Gilda Torano-Peraza, Misladys Rodriguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela Garcia-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucia Andrade, Jose Luis Di Fabio, Elizabeth Castaneda
Summary: A multicentre, retrospective observational study in eight Latin American and Caribbean countries assessed the direct effect of pneumococcal conjugate vaccines (PCVs) on the distribution of pneumococcal serotypes causing invasive pneumococcal disease in children younger than 5 years. The study found a significant decrease in the percentage of vaccine serotypes in PCV countries after PCV introduction.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Mischa H. Koenen, Ruben C. A. de Groot, Wouter A. A. de Steenhuijsen Piters, Mei Ling J. N. Chu, Kayleigh Arp, Raiza Hasrat, Ad C. J. M. de Bruijn, Silvia C. Estevao, Erhard Van der Vries, Jeroen D. Langereis, Marianne Boes, Debby Bogaert, Annemarie M. C. van Rossum, Wendy W. J. Unger, Lilly M. Verhagen
Summary: M.pneumoniae carriage is highly prevalent in children with recurrent infections, and carriers have a less diverse microbiota with an overrepresentation of disease-associated microbiota members compared to non-carriers.
Article
Biochemistry & Molecular Biology
Brooklyn E. Taylor, Chieh A. Lee, Thomas E. Zapadka, Amy Y. Zhou, Katherine G. Barber, Zakary R. R. Taylor, Scott J. Howell, Patricia R. Taylor
Summary: Retinal neovascularization is a common cause of vision loss in diseases such as proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This study found that Interleukin-17A (IL-17A) plays a crucial role in the onset and progression of non-proliferative diabetic retinopathy. The researchers also discovered that IL-17A enhances vascular endothelial growth factor (VEGF) production, promotes retinal endothelial cell proliferation, and enhances VEGF-dependent vascular angiogenesis, ultimately leading to retinal neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Asa Sjoling, Leila Sadeghipoorjahromi, Daniel Novak, Joshua Tobias
MICROBIOLOGICAL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Marie Hagbom, Daniel Novak, Malin Ekstrom, Younis Khalid, Maria Andersson, Magnus Lindh, Johan Nordgren, Lennart Svensson
Article
Pediatrics
Rebecka Bramsved, Susann Regber, Daniel Novak, Kirsten Mehlig, Lauren Lissner, Staffan Marild
Article
Pediatrics
Daniel Novak, Ann-Mari Svennerholm
Article
Immunology
D. Novak, M. Novak
INTERNATIONAL JOURNAL OF STD & AIDS
(2012)
Article
Infectious Diseases
Daniel Novak, Anna Lundgren, Susanne Westphal, Sindri Valdimarsson, Martin L. Olsson, Birger Trollfors
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Multidisciplinary Sciences
Daniel Novak, Gun Forsander, Eva Kristiansen, Anna Svedlund, Per Magnusson, Diana Swolin-Eide
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Diana Swolin-Eide, Gun Forsander, Auste Pundziute Lycka, Daniel Novak, Johannes Grillari, Andreas B. Diendorfer, Matthias Hackl, Per Magnusson
Summary: This case-control study aimed to investigate potential differences in circulating miRNAs between young individuals with long-duration type 1 diabetes (T1D) and healthy controls, as well as the expression of these identified miRNAs across different tissues. The results showed that 27 miRNAs were upregulated and one was downregulated in T1D. Six of these miRNAs were tissue-enriched. These findings have important implications for studying biomarkers for diabetes-related complications.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Masuma Novak, Daniel Novak
SEXUAL & REPRODUCTIVE HEALTHCARE
(2013)
Article
Infectious Diseases
DP Novak, RB Karlsson
SEXUALLY TRANSMITTED INFECTIONS
(2006)
Article
Public, Environmental & Occupational Health
DP Novak, L Lindholm, M Jonsson, RB Karlsson
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2004)