Article
Immunology
Asia -Sophia Wolf, Elena Mitsi, Scott Jones, Simon P. Jochems, Lucy Roalfe, Deus Thindwa, James E. Meiring, Jacquline Msefula, Farouck Bonomali, Tikhala Makhaza Jere, Maurice Mbewe, Andrea M. Collins, Stephen B. Gordon, Melita A. Gordon, Daniela M. Ferreira, Neil French, David Goldblatt, Robert S. Heyderman, Todd D. Swarthout
Summary: This study investigates the protective mechanism of childhood pneumococcal conjugate vaccine (PCV) against pneumococcal carriage. The results show no clear relationship between antibody quality and protection from carriage, suggesting that PCV13-driven antibody quality may mature with age and exposure.
Article
Multidisciplinary Sciences
Sweta M. Patel, Yazdani B. Shaik-Dasthagirisaheb, Morgan Congdon, Rebecca R. Young, Mohamed Z. Patel, Tiny Mazhani, Sefelani Boiditswe, Tirayaone Leburu, Kwana Lechiile, Tonya Arscott-Mills, Andrew P. Steenhoff, Kristen A. Feemster, Samir S. Shah, Coleen K. Cunningham, Stephen I. Pelton, Matthew S. Kelly
Summary: The introduction of pneumococcal conjugate vaccines has reduced invasive pneumococcal disease burden, but the effectiveness of these vaccines can be reduced by an increase in non-vaccine serotype diseases.
Article
Immunology
Elnaz Afshari, Reza Ahangari Cohan, Mohammad Sadegh Shams Nosrati, Seyed Fazlollah Mousavi
Summary: This study investigates the protective potential of co-immunization with pneumococcal PhtD and novel rPspA proteins in mice against pneumococcal sepsis infection. The results demonstrate that the co-administration of rPspA+PhtD formulation induces a strong immune response, increases antibody levels, and exhibits effective bacterial clearance.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Fang-Feng Chiu, Ling-Ling Tu, Wangxue Chen, Hongyan Zhou, Bing-Sin Liu, Shih-Jen Liu, Chih-Hsiang Leng
Summary: In this study, the development of a broad-spectrum protein-based pneumococcal vaccine that provides protection against multiple serotypes of Streptococcus pneumoniae was presented. The vaccine induced higher titres of IgG and IgA, resulting in systemic mucosal immunity and enhanced opsonic phagocytosis. The immunogenicity of the vaccine reduced the bacterial load and increased the survival rate of mice.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Immunology
Effua Usuf, Christian Bottomley, Rebecca Gladstone, Ebrima Bojang, Kaddijatou Jawneh, Isatou Cox, Edrissa Jallow, Abdoulie Bojang, Brian Greenwood, Richard A. Adegbola, Stephen D. Bentley, Philip C. Hill, Anna Roca
Summary: The study shows that the prevalence of PCV13 VT has decreased since the introduction of PCV13, but significant carriage of these serotypes remains in all age groups. The prevalence of PCV13 NVT varies among different age groups, with an increase in children under 2 years old and a decrease in older children and adults.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Ryan Robinson, Christopher A. Myerscough, Nengjie He, Helen Hill, Wendi Shepherd, Patricia Gonzalez-Dias, Konstantinos Liatsikos, Samuel Latham, Fred Fyles, Klara Doherty, Phoebe Hazenberg, Fathimath Shiham, Daniella Mclenghan, Hugh Adler, Vicki Randles, Seher Zaidi, Angela Hyder-Wright, Elena Mitsi, Hassan Burhan, Ben B. Morton, Jamie M. Rylance, Maia M. Lesosky, Stephen Gordon, Andrea Collins, Daniela Ferreira
Summary: Experimental Human Pneumococcal Challenge (EHPC) is a safe procedure for studying vaccine research, with no serious adverse events related to pneumococcal inoculation. Colonised individuals were more likely to experience safety events, but most symptoms were mild and could be managed conservatively. Outpatient human pneumococcal challenge can be conducted safely with appropriate safety monitoring procedures in place.
Article
Multidisciplinary Sciences
Muhammad Imran Nisar, Fyezah Jehan, Shahira Shahid, Sheraz Ahmed, Sadia Shakoor, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Farah Khalid, Sajid Muhammad, Benjamin M. Althouse, Hao Hu, Cynthia G. Whitney, Asad Ali, Anita K. M. Zaidi, Saad B. Omer, Najeeha Iqbal
Summary: Pakistan introduced the PCV10 vaccine in 2013 and conducted a study on infants from 2014-2018. The study showed a significant decrease in carriage of vaccine-related serotypes and an increase in non-vaccine related serotypes. This highlights the need for continuous monitoring and evaluation of existing vaccine formulations.
Article
Immunology
Lukas Muri, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammueller, Gerd Pluschke
Summary: Two different physiological opsonophagocytosis assay formats yielded consistent results, emphasizing the importance of alternative complement pathway activation for efficient killing in vaccine-naive individuals. In contrast, alternative pathway inhibition did not affect pneumococcal killing in PCV13-vaccinated subjects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Infectious Diseases
Amgad Gamil, Kulkanya Chokephaibulkit, Wanatpreeya Phongsamart, Chonnamet Techasaensiri, Barameht Piralam, Ruangwit Thamaree
Summary: This review examines the epidemiology, serotype prevalence, antibiotic resistance, and national vaccination recommendations for pneumococcal disease in Thailand. PCV13 is the only vaccine licensed for adults in Thailand and has the potential to reduce disease burden in all age groups, particularly in children and older adults.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Aishatu L. Adamu, J. Ojal, Isa A. Abubakar, Kofo A. Odeyemi, Musa M. Bello, Christy A. N. Okoromah, Boniface Karia, Angela Karani, Donald. Akech, Victor Inem, J. Anthony G. Scott, Ifedayo M. O. Adetifa
Summary: In Nigeria, the introduction of pneumococcal conjugate vaccines has led to a significant decrease in carriage of vaccine-serotype pneumococci, indicating a comparable reduction in pneumococcal disease.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Willem R. Miellet, Janieke van Veldhuizen, Mioara A. Nicolaie, Rob Mariman, Hester J. Bootsma, Thijs Bosch, Nynke Y. Rots, Elisabeth A. M. Sanders, Josine van Beek, Krzysztof Trzcinski
Summary: Influenza-like illness exacerbates pneumococcal colonization in older adults, with this effect persisting beyond recovery from the illness.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Genetics & Heredity
Sophie Belman, Sona Soeng, Chansovannara Soputhy, Rebecca Gladstone, Paulina A. Hawkins, Robert F. Breiman, Lesley McGee, Stephen D. Bentley, Stephanie W. Lo, Paul Turner
Summary: Streptococcus pneumoniae is a major cause of childhood mortality globally and in Cambodia. Monitoring genetic shifts and antimicrobial-resistance patterns is crucial for assessing the impact of vaccination campaigns.
MICROBIAL GENOMICS
(2022)
Article
Immunology
Geofrey Makenga, George Mtove, J. Kevin Yin, Abubakary Mziray, Veneranda M. Bwana, William Kisinza, Julius Mjema, Ben Amos, Laura Antony, Delane Shingadia, Shahin Oftadeh, Robert Booy
Summary: This study investigated the antibody response and vaccine efficacy of PCV13 in HIV-infected children. The results showed a reduction in acquisition of new vaccine serotypes of S. pneumoniae in the PCV13 group compared to the Hib vaccine group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Heidi Smith-Vaughan, Beth Temple, Vo Thi Trang Dai, Pham Thi Hoan, Ho Nguyen Loc Thuy, Thanh V. Phan, Kathryn Bright, Nguyen Trong Toan, Doan Y. Uyen, Cattram Duong Nguyen, Jemima Beissbarth, Belinda Daniela Ortika, Monica Larissa Nation, Eileen Margaret Dunne, Jason Hinds, Jana Lai, Catherine Satzke, Tran Ngoc Huu, Kim Mulholland
Summary: This study evaluated the impact of different pneumococcal conjugate vaccine (PCV10) schedules on carriage rates and found that the 3 + 1, 2 + 1, 3 + 0, and two-dose schedules were effective in reducing vaccine-type carriage. In Vietnam, there were no discernible differences in carriage rates between the 2 + 1 and 3 + 0 schedules during the first two years of life.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Immunology
Lassane Kabore, Tolulope Adebanjo, Berthe Marie Njanpop-Lafourcade, Soumeya Ouangraoua, Felix T. Tarbangdo, Bertrand Meda, Srinivasan Velusamy, Brice Bicaba, Flavien Ake, Lesley McGee, Seydou Yaro, Edouard Betsem, Alain Gervaix, Bradford D. Gessner, Cynthia G. Whitney, Jennifer C. Moisi, Chris A. Van Beneden
Summary: Within 3 years of PCV13 implementation in Burkina Faso, substantial reductions in the percentage of pneumococcal carriers with a vaccine-type were documented among children under 5 years old, but not among individuals aged 5 years and above. More time, a change in the PCV13 schedule, or both, may be needed to better control pneumococcal carriage in this setting.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Ethics
Chris Degeling, Julie Hall, Jane Johnson, Roba Abbas, Shopna Bag, Gwendolyn L. Gilbert
Summary: The study found that public support for using the COVIDSafe app to enhance contact tracing systems in Australia is high, depending on the protections enacted in the app design and legislation. Despite sustained skepticism in media coverage, there is still underlying willingness to trust Australian governing institutions.
HEALTH CARE ANALYSIS
(2022)
Article
Allergy
Daniel J. Tan, Caroline J. Lodge, Eugene Haydn Walters, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, Rangi Kandane-Rathnayake, Fahad M. Aldakheel, Bircan Erbas, Garun S. Hamilton, Paul S. Thomas, Mark Hew, Mimi L. K. Tang, Michael J. Abramson, Jennifer L. Perret, Shyamali C. Dharmage
Summary: This study found that subclinical inflammation exists in adults with spontaneous asthma remission, and these inflammatory biomarkers are associated with future asthma relapse and lung function decline. Bronchial hyperresponsiveness (BHR) and serum inflammatory cytokines have prognostic value in predicting outcomes in adults with spontaneous asthma remission, suggesting the need for closer monitoring and follow-up in high-risk individuals.
Editorial Material
Medicine, General & Internal
Gwendolyn L. Gilbert
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Immunology
Nusrat Homaira, Roxanne Strachan, Helen Quinn, Sean Beggs, Mejbah Bhuiyan, Asha Bowen, Laura K. Fawcett, Gwendolyn L. Gilbert, Stephen B. Lambert, Kristine Macartney, Helen S. Marshall, Andrew C. Martin, Gabrielle McCallum, Angela McCullagh, Tim McDonald, Hiran Selvadurai, Peter McIntyre, Shahin Oftadeh, Sarath Ranganathan, Thomas Saunders, Sadasivam Suresh, Claire Wainwright, Angela Wilson, Melanie Wong, Adam Jaffe, Tom Snelling
Summary: In this nationwide case-control study conducted in 11 pediatric tertiary hospitals in Australia, we aimed to assess the direct protective effect of 13-valent pneumococcal conjugate vaccine (13vPCV) against invasive pneumococcal pneumonia (IPP) in children. The study concluded that the direct protective effect of 13vPCV against IPP among Australian children was not significant.
Review
Allergy
Melanie Lloyd, Nandinee Patel, Daniel Munblit, Mimi L. K. Tang
Summary: Multiple novel interventions for food allergy are currently in development, aiming to reduce or eliminate allergic reactions. However, the success of these therapies in improving patients' lives is difficult to determine due to limited understanding of the alignment between clinical trial efficacy endpoints and patient-centered outcomes. This review assists clinicians in interpreting clinical trial outcomes and effectively communicating risks and outcomes to patients during shared decision-making.
(c) 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:998-1007)
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Nutrition & Dietetics
Toby Mansell, Annalee Furst, Martin O'Hely, Melinda Chang, Anne-Louise Ponsonby, Peter Vuillermin, Mimi L. K. Tang, David Burgner, Richard Saffery, Lars Bode
Summary: The concentration of human milk oligosaccharides (HMOs) at 6 weeks postpartum is associated with infant anthropometry, particularly within the first 6 months. For secretor mothers, higher levels of 2'FL are associated with increased weight and length in infants, while higher levels of lacto-N-tetraose are associated with increased weight and length in nonsecretor mothers.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Clinton M. G. Colaco, Matthew O'Sullivan, Hayden Zhang, Danica Huynh, Vitali Sintchenko, Shahin Oftadeh, Gwendolyn L. Gilbert, Ravindra Dotel
Summary: This study retrospectively investigated the clinical and serotype analysis of pneumococcus bacteraemia over a 10-year period, finding that most patients were not vaccinated against pneumococcus, and the coverage rate of vaccines was low.
INTERNAL MEDICINE JOURNAL
(2023)
Letter
Pediatrics
Shivanthan Shanthikumar, Katherine Chen, Victoria X. Soriano, Lily Nguyen, Jennifer J. Koplin, Mimi L. K. Tang, Adrian J. Lowe, Caroline J. Lodge, Nur Sabrina Idrose, Sarath Ranganathan, Bruce Thompson, Shyamali C. Dharmage, Rachel L. Peters
PEDIATRIC PULMONOLOGY
(2023)
Article
Allergy
Melanie Lloyd, Paxton Loke, Douglas P. Mack, Scott H. Sicherer, Michael R. Perkin, Robert Boyle, Agnes Sze Yin Leung, Bee Wah Lee, Michael Levin, Katharina Blumchen, Alessandro Fiocchi, Motohiro Ebisawa, Lucila Camargo Lopes de Oliveira, Mimi L. K. Tang
Summary: Food allergy is a chronic disease that affects individuals of all ages and is a significant public health problem globally. This narrative overview examines clinical management strategies for IgE-mediated food allergy in children around the world to understand variations in practice.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Letter
Allergy
Gabriel Lins de Holanda Coelho, Melanie Lloyd, Mimi L. K. Tang, Audrey DunnGalvin
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Allergy
Elizabeth Huiwen Tham, Agnes Sze Yin Leung, Kiwako Yamamoto-Hanada, Lamia Dahdah, Thulja Trikamjee, Vrushali Vijay Warad, Matthew Norris, Elsy Navarrete, Daria Levina, Miny Samuel, Andre van Niekerk, Santiago Martinez, Anne K. Ellis, Leonard Bielory, Hugo van Bever, Dana Wallace, Derek K. Chu, Daniel Munblit, Mimi L. K. Tang, James Sublett, Gary Wing Kin Wong
Summary: This study conducted a comprehensive assessment of Clinical Practice Guidelines (CPGs) for primary prevention of food allergy and atopic dermatitis. It found that although some guidelines had high quality, they performed poorly in terms of global applicability. The study calls for guideline developers to consider stakeholders' preferences, local applicability, and adapt existing recommendations to different geographical settings.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Jane H. Williams, Claire Hooker, Gwendolyn L. Gilbert, Suyin Hor, Chris Degeling
Summary: Public health decisions are often polarised due to diverse interpretations of evidence and differing value choices. A definition of polarisation in the context of public health expertise should consider epistemic and social values. Oversimplification of complex issues and dichotomous groupings should be avoided, and the one-size-fits-all approach of independence is insufficient for addressing expert polarisation. The role of value difference should be acknowledged in both polarisation and evidence-based decision making.
Review
Allergy
Chia-Lun Chang, Gulshan Bano Ali, Jonathan Pham, Shyamali C. C. Dharmage, Caroline J. J. Lodge, Mimi L. K. Tang, Adrian J. J. Lowe
Summary: This study systematically synthesized the association between BMI trajectories in childhood and allergic diseases. The findings suggest that a persistently high BMI between 6 and 10 years of age may be associated with an increased risk of asthma at 18 years, and a rapid increase in BMI in the first 2 years of life may be associated with subsequent asthma. Maintaining a normal BMI trajectory during childhood may reduce the risk of asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Infectious Diseases
R. Dotel, G. L. Gilbert, S. N. Hutabarat, J. S. Davis, M. V. N. O'Sullivan
Summary: The objective of this study was to assess the effectiveness of adding rifampicin to conventional treatment for Staphylococcus aureus bacteraemia. The results showed that while adding rifampicin significantly reduced bacteriological failure and recurrences, it did not provide any mortality benefit. Therefore, there is currently no evidence to support the use of rifampicin in the treatment of Staphylococcus aureus bacteraemia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Allergy
Caroline J. Lodge, Nilakshi Waidyatillake, Rachel L. Peters, Merryn Netting, Xin Dai, John Burgess, Catherine J. Hornung, Kirsten P. Perrett, Mimi L. K. Tang, Jennifer J. Koplin, Shyamali C. Dharmage
Summary: This study synthesized the best available evidence from randomized controlled trials to evaluate the efficacy and safety of oral immunotherapy (OIT) for desensitization (DS) and remission (SU) in peanut, hen's egg, and cow's milk allergies. The results showed that OIT had a positive effect on desensitization, but it also increased the risk of allergic reactions.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)