Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs

Mechanical loading of intervertebral disc modulates microglia proliferation, activation, and chemotaxis

(2018) S.E. Navone et al.   OSTEOARTHRITIS AND CARTILAGE

Macrophage-derived inflammatory cytokines regulate growth factors and pain-related molecules in mice with intervertebral disc injury

(2018) Masayuki Miyagi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Human nucleus pulposus intervertebral disc cells becoming senescent using different treatments exhibit a similar transcriptional profile of catabolic and inflammatory genes

(2017) Sotiris-Spyros Vamvakas et al.   EUROPEAN SPINE JOURNAL

Biomechanics of the human intervertebral disc: A review of testing techniques and results

(2017) N. Newell et al.   Journal of the Mechanical Behavior of Biomedical Materials

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Theo Vos et al.   LANCET

Corneal epithelial cells exposed to shear stress show altered cytoskeleton and migratory behaviour

(2017) Sara Molladavoodi et al.   PLoS One

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

(2017) Qin Bian et al.   Bone Research

Mast Cell-Intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in Discogenic Back Pain

(2017) Matthew G. Wiet et al.   Scientific Reports

Intervertebral Disc Cells Produce Interleukins Found in Patients with Back Pain

(2016) Yejia Zhang et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Disc height loss and restoration via injectable hydrogel influences adjacent segment mechanics in-vitro

(2016) Christian Balkovec et al.   CLINICAL BIOMECHANICS

NF- B Signaling Pathway in Controlling Intervertebral Disk Cell Response to Inflammatory and Mechanical Stressors

(2016) R. Tisherman et al.   PHYSICAL THERAPY

Loading-Induced Heat-Shock Response in Bovine Intervertebral Disc Organ Culture

(2016) Wai Hon Chooi et al.   PLoS One

Compression loading-induced stress responses in intervertebral disc cells encapsulated in 3D collagen constructs

(2016) Wai Hon Chooi et al.   Scientific Reports

N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions

(2016) Priscilla Y Hwang et al.   Scientific Reports

Human corneal epithelial cell response to substrate stiffness

(2015) Sara Molladavoodi et al.   Acta Biomaterialia

Advancing the cellular and molecular therapy for intervertebral disc disease

(2015) Daisuke Sakai et al.   ADVANCED DRUG DELIVERY REVIEWS

The degenerative state of the intervertebral disk independently predicts the failure of human lumbar spine to high rate loading: An experimental study

(2015) Ron Noah Alkalay et al.   CLINICAL BIOMECHANICS

The biology behind the human intervertebral disc and its endplates

(2015) K. A. Tomaszewski et al.   FOLIA MORPHOLOGICA

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells

(2015) Benjamin A. Walter et al.   SPINE

TNFα Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs

(2015) Benjamin A. Walter et al.   PLoS One

How Should We Grade Lumbar Disc Herniation and Nerve Root Compression? A Systematic Review

(2014) Yiping Li et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

(2014) Priscilla Y. Hwang et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Physiological Loading Can Restore the Proteoglycan Content in a Model of Early IVD Degeneration

(2014) Rahul Gawri et al.   PLoS One

High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain

(2014) Rahul Gawri et al.   ARTHRITIS RESEARCH & THERAPY

Effects of initial boost with TGF-beta 1 and grade of intervertebral disc degeneration on 3D culture of human annulus fibrosus cells

(2014) Aldemar Andres Hegewald et al.   Journal of Orthopaedic Surgery and Research

Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro

(2013) J.R. Henstock et al.   BONE

Three Functions of Cadherins in Cell Adhesion

(2013) Jean-Léon Maître et al.   CURRENT BIOLOGY

Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level

(2013) Cornelia Neidlinger-Wilke et al.   EUROPEAN SPINE JOURNAL

Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc

(2013) D. T. Bridgen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs

(2013) Cornelis P. L. Paul et al.   PLoS One

Intervertebral disc degeneration alters lumbar spine segmental stiffness in all modes of loading under a compressive follower load

(2013) Shannon A. Zirbel et al.   Spine Journal

Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted

(2012) Rosalyn D. Abbott et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anular delamination strength of human lumbar intervertebral disc

(2012) Diane E. Gregory et al.   EUROPEAN SPINE JOURNAL

Diversity of intervertebral disc cells: phenotype and function

(2012) Girish Pattappa et al.   JOURNAL OF ANATOMY

Cyclic stretch-induced apoptosis in rat annulus fibrosus cells is mediated in part by endoplasmic reticulum stress through nitric oxide production

(2011) Yue-Hui Zhang et al.   EUROPEAN SPINE JOURNAL

Determination of annulus fibrosus cell response to tensile strain as a function of duration, magnitude, and frequency

(2011) Gwendolyn Sowa et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Fracture of the vertebral endplates, but not equienergetic impact load, promotes disc degeneration in vitro

(2011) Stefan Dudli et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells

(2011) Cornelia Neidlinger-Wilke et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Formation of lamellar cross bridges in the annulus fibrosus of the intervertebral disc is a consequence of vascular regression

(2011) Lachlan J. Smith et al.   MATRIX BIOLOGY

Intervertebral Disk Nutrition: A Review of Factors Influencing Concentrations of Nutrients and Metabolites

(2011) Thijs Grunhagen et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

What Is the Source of Chronic Low Back Pain and Does Age Play a Role?

(2011) Michael J. DePalma et al.   PAIN MEDICINE

Extracellular Matrix Ligand and Stiffness Modulate Immature Nucleus Pulposus Cell-Cell Interactions

(2011) Christopher L. Gilchrist et al.   PLoS One

Influence of Interpersonal Geometrical Variation on Spinal Motion Segment Stiffness

(2011) Gerdine J. M. Meijer et al.   SPINE

Tissue Engineering of the Intervertebral Disc With Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Growth Factors

(2011) Kwang-Il Lee et al.   SPINE

Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres

(2011) Minting Yuan et al.   Spine Journal

Intervertebral Disk Tissue Engineering Using Biphasic Silk Composite Scaffolds

(2011) Sang-Hyug Park et al.   TISSUE ENGINEERING PART A

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen–GAG scaffold

(2010) Michael B. Keogh et al.   Acta Biomaterialia

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

(2010) Christoph Weiler et al.   EUROPEAN SPINE JOURNAL

The influence of torsion on disc herniation when combined with flexion

(2010) Samuel P. Veres et al.   EUROPEAN SPINE JOURNAL

Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells

(2010) Yue-Hui Zhang et al.   MATRIX BIOLOGY

A Novel Thiol-Modified Hyaluronan and Elastin-Like Polypetide Composite Material for Tissue Engineering of the Nucleus Pulposus of the Intervertebral Disc

(2010) Isaac L. Moss et al.   SPINE

The relationship between disc degeneration, low back pain, and human pain genetics

(2010) Kenneth M.C. Cheung   Spine Journal

Cyclic Tensile Stress Exerts a Protective Effect on Intervertebral Disc Cells

(2009) Gwendolyn Sowa et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs

(2009) Christine Lyn Le Maitre et al.   ARTHRITIS AND RHEUMATISM

The role of axial torque in disc herniation

(2009) Leigh W. Marshall et al.   CLINICAL BIOMECHANICS

The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration

(2009) Lachlan J. Smith et al.   EUROPEAN SPINE JOURNAL

The intervertebral disc: From pathophysiology to tissue engineering

(2009) Johann Clouet et al.   JOINT BONE SPINE

A microstructural investigation of intervertebral disc lamellar connectivity: detailed analysis of the translamellar bridges

(2009) Meredith L. Schollum et al.   JOURNAL OF ANATOMY

Cellular mechanobiology of the intervertebral disc: New directions and approaches

(2009) Adam H. Hsieh et al.   JOURNAL OF BIOMECHANICS

Self-Assembly of Aligned Tissue-Engineered Annulus Fibrosus and Intervertebral Disc Composite Via Collagen Gel Contraction

(2009) Robby D. Bowles et al.   TISSUE ENGINEERING PART A

Guiding cell migration in 3D: A collagen matrix with graded directional stiffness

(2009) Ektoras Hadjipanayi et al.   CELL MOTILITY AND THE CYTOSKELETON

Integrin-mediated signalling through the MAP-kinase pathway

(2008) K.L. Yee et al.   IET Systems Biology

Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc

(2008) Siyuan Li et al.   JOURNAL OF ANATOMY

Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

(2008) Tae-Jin Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1

(2008) Rebecca K. Studer et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Intervertebral disc cell response to dynamic compression is age and frequency dependent

(2008) Casey L. Korecki et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ISSLS Prize Winner: Microstructure and Mechanical Disruption of the Lumbar Disc Annulus

(2008) Meredith L. Schollum et al.   SPINE

TNF-Alpha in Nucleus Pulposus Induces Sensory Nerve Growth

(2008) Shinu Hayashi et al.   SPINE

Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc

(2008) Kern Singh et al.   SPINE

The Twin Spine Study: Contributions to a changing view of disc degeneration†

(2008) Michele C. Battié et al.   Spine Journal

Intervertebral Disc Tissue Engineering Using a Novel Hyaluronic Acid–Nanofibrous Scaffold (HANFS) Amalgam

(2008) Leon J. Nesti et al.   TISSUE ENGINEERING PART A