Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system

(2015) Takuto Kurakawa et al.   Spine Journal

CCN2 Suppresses Catabolic Effects of Interleukin-1β through α5β1 and αVβ3 Integrins in Nucleus Pulposus Cells

(2014) Cassie M. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lumbar intervertebral disc: From embryonic development to degeneration

(2013) Pauline Colombier et al.   JOINT BONE SPINE

Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis

(2013) Kathryn Ellis et al.   JOURNAL OF CELL BIOLOGY

Endogenous TGF-β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-κB activation

(2013) Yong Zhu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: Implications of dysregulated expression in disc disease

(2012) Qianghua Wu et al.   ARTHRITIS AND RHEUMATISM

Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3

(2012) Rosalyn D. Abbott et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

(2012) Chitra Lekha Dahia et al.   PLoS One

Anabolic Effects of Peniel 2000, a Peptide That Regulates TGF-β1 Signaling on Intervertebral Disc Degeneration

(2012) Young-Joon Kwon et al.   SPINE

Aggrecan, an unusual polyelectrolyte: Review of solution behavior and physiological implications

(2011) Preethi L. Chandran et al.   Acta Biomaterialia

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

The effects of dynamic loading on the intervertebral disc

(2011) Samantha C. W. Chan et al.   EUROPEAN SPINE JOURNAL

Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration

(2011) Helen E. Gruber et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

TGF-β signaling plays an essential role in the growth and maintenance of intervertebral disc tissue

(2011) Hongting Jin et al.   FEBS LETTERS

aV integrins and TGF-β-induced EMT: a circle of regulation

(2011) Fahmy A. Mamuya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

(2011) K.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord

(2010) Makarand V. Risbud et al.   DEVELOPMENTAL DYNAMICS

Degeneration and regeneration of the intervertebral disc: lessons from development

(2010) L. J. Smith et al.   Disease Models & Mechanisms

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

(2009) Seungcheol Lee et al.   CLINICAL BIOCHEMISTRY

Expression and Role of Connective Tissue Growth Factor in Painful Disc Fibrosis and Degeneration

(2009) Baogan Peng et al.   SPINE

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The pathophysiology of disc degeneration

(2008) A. G. Hadjipavlou et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Matrix Remodeling During Intervertebral Disc Growth and Degeneration Detected by Multichromatic FAST Staining

(2008) Victor Y.L. Leung et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment

(2008) P. Prithvi Raj   Pain Practice

The Notochord, Notochordal cell and CTGF/CCN-2: ongoing activity from development through maturation

(2008) W. Mark Erwin   Journal of Cell Communication and Signaling