Human nucleus pulposus intervertebral disc cells becoming senescent using different treatments exhibit a similar transcriptional profile of catabolic and inflammatory genes

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

(2016) Eleni Liakou et al.   Aging-US

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

Molecular mechanisms of biological aging in intervertebral discs

(2016) Nam V. Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Gene expression profiling of replicative and induced senescence

(2014) Maggie Purcell et al.   CELL CYCLE

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Senescent cells spread the word: non-cell autonomous propagation of cellular senescence

(2013) Nilgun Tasdemir et al.   EMBO JOURNAL

Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc

(2013) Sarit Sara Sivan et al.   EUROPEAN SPINE JOURNAL

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

(2013) Nam V. Vo et al.   Spine Journal

In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes

(2013) Seo-Won Jeong et al.   Spine Journal

Elevated IL-1β and IL-6 levels in lumbar herniated discs in patients with sciatic pain

(2012) Pablo Andrade et al.   EUROPEAN SPINE JOURNAL

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Cytokine evaluation in individuals with low back pain using discographic lavage

(2010) Jason M. Cuellar et al.   Spine Journal

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM

High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response

(2009) Eleni Mavrogonatou et al.   DNA REPAIR

Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration

(2009) Beatrice E. Bachmeier et al.   EUROPEAN SPINE JOURNAL

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs

(2009) Ki-Won Kim et al.   Spine Journal

Senescent cells in the intervertebral disc: numbers and mechanisms

(2009) Dimitris Kletsas   Spine Journal

Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels

(2008) JPHJ Rutges et al.   JOURNAL OF PATHOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY