Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials
出版年份 2019 全文链接
标题
Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials
作者
关键词
-
出版物
MOLECULES
Volume 24, Issue 23, Pages 4312
出版商
MDPI AG
发表日期
2019-11-26
DOI
10.3390/molecules24234312
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma
- (2019) Margarita Gutova et al. Frontiers in Oncology
- Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma
- (2019) Man Li et al. Stem Cell Research & Therapy
- Intranasal teriflunomide microemulsion: An improved chemotherapeutic approach in glioblastoma
- (2019) Dnyandev Gadhave et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma
- (2019) Edilson Ribeiro de Oliveira Junior et al. PHARMACEUTICAL RESEARCH
- Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles
- (2019) Flávia Sousa et al. JOURNAL OF CONTROLLED RELEASE
- Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach
- (2019) J. H. Azambuja et al. MOLECULAR NEUROBIOLOGY
- Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: Characterization, nasal absorption, histopathology and cell line study
- (2018) Anam Khan et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro
- (2018) Mariana Colombo et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment
- (2018) Lakshmi Pallavi Ganipineni et al. JOURNAL OF CONTROLLED RELEASE
- Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies
- (2018) Patrícia C. Pires et al. JOURNAL OF CONTROLLED RELEASE
- Cell penetrating peptides in ocular drug delivery: State of the art
- (2018) S. Pescina et al. JOURNAL OF CONTROLLED RELEASE
- Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
- (2018) Mukta Agrawal et al. JOURNAL OF CONTROLLED RELEASE
- Mechanism of intranasal drug delivery directly to the brain
- (2018) Tyler P. Crowe et al. LIFE SCIENCES
- Heart tissue repair and cardioprotection using drug delivery systems
- (2018) Laura Saludas et al. MATURITAS
- Mitochondrial dysfunction induced by leflunomide and its active metabolite
- (2018) Jiekun Xuan et al. TOXICOLOGY
- Anti-inflammatory drug, leflunomide and its metabolite teriflunomide inhibit NSCLC proliferation in vivo and in vitro
- (2018) Liyang Jiang et al. TOXICOLOGY LETTERS
- Alterations in Cell Motility, Proliferation, and Metabolism in Novel Models of Acquired Temozolomide Resistant Glioblastoma
- (2018) D. M. Tiek et al. Scientific Reports
- Malignant Gliomas as Second Neoplasms in Pediatric Cancer Survivors: Neuropathological Study
- (2018) Ewa Izycka-Swieszewska et al. Biomed Research International
- Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy
- (2018) Elif Ozdemir-Kaynak et al. Frontiers in Physiology
- Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions
- (2018) Luis V. Syro et al. Frontiers in Endocrinology
- Beyond the Blood:Brain Barrier: The Importance of Central Nervous System (CNS) Pharmacokinetics for the Treatment of CNS Tumors, Including Diffuse Intrinsic Pontine Glioma
- (2018) Katherine Elizabeth Warren Frontiers in Oncology
- Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
- (2018) Fabio Sonvico et al. Pharmaceutics
- Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting
- (2018) Liuxiang Chu et al. DRUG DELIVERY
- CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015
- (2018) Quinn T Ostrom et al. NEURO-ONCOLOGY
- Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development
- (2018) Thomas Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers
- (2018) Javier Menéndez-Menéndez et al. International Journal of Endocrinology
- Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma
- (2018) Bryan G. Harder et al. Frontiers in Oncology
- In vivo tracking of the tropism of mesenchymal stem cells to malignant gliomas using reporter gene-based MR imaging
- (2017) Minghui Cao et al. INTERNATIONAL JOURNAL OF CANCER
- Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells
- (2017) Xue Wang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles
- (2017) Emine Sekerdag et al. JOURNAL OF CONTROLLED RELEASE
- Targeted Drug Delivery via Folate Receptors for the Treatment of Brain Cancer: Can the Promise Deliver?
- (2017) Jianfeng Guo et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Nanomelatonin triggers superior anticancer functionality in a human malignant glioblastoma cell line
- (2017) Sanjeev Kumar Yadav et al. NANOTECHNOLOGY
- Global incidence of malignant brain and other central nervous system tumors by histology, 2003–2007
- (2017) Rebecca Leece et al. NEURO-ONCOLOGY
- Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats
- (2017) Maria Uldall et al. NEUROSCIENCE LETTERS
- Efficacy of a ketogenic diet with concomitant intranasal perillyl alcohol as a novel strategy for the therapy of recurrent glioblastoma
- (2017) Juliana Santos et al. Oncology Letters
- The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells
- (2017) Jing An et al. Oncotarget
- Efficacy and safety of long-term therapy for high-grade glioma with temozolomide: A meta-analysis
- (2017) Weilin Xu et al. Oncotarget
- Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model
- (2017) Michael E. Barish et al. Stem Cells Translational Medicine
- Time-sequenced drug delivery approaches towards effective chemotherapeutic treatment of glioma
- (2017) Menghuan Li et al. Materials Horizons
- A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles
- (2017) Flávia Sousa et al. Scientific Reports
- Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy
- (2017) Matthias Van Woensel et al. Scientific Reports
- Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival
- (2016) Antonella Mangraviti et al. BIOMATERIALS
- Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier
- (2016) David S. Hersh et al. CURRENT PHARMACEUTICAL DESIGN
- Curcumin changes the polarity of tumor-associated microglia and eliminates glioblastoma
- (2016) Sumit Mukherjee et al. INTERNATIONAL JOURNAL OF CANCER
- Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration
- (2016) Matthias Van Woensel et al. JOURNAL OF CONTROLLED RELEASE
- Oral bioavailability of curcumin: problems and advancements
- (2016) Weidong Liu et al. JOURNAL OF DRUG TARGETING
- Advances in Targeted Drug Delivery Approaches for the Central Nervous System Tumors: The Inspiration of Nanobiotechnology
- (2016) Jianing Meng et al. Journal of Neuroimmune Pharmacology
- The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?
- (2016) Yan Michael Li et al. JOURNAL OF NEUROSURGERY
- Thermosensitive PLA based nanodispersion for targeting brain tumor via intranasal route
- (2016) Darshana S. Jain et al. Materials Science & Engineering C-Materials for Biological Applications
- Sleep-wake disturbance in patients with brain tumors
- (2016) Terri S. Armstrong et al. NEURO-ONCOLOGY
- Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
- (2016) Jan C. Buckner et al. NEW ENGLAND JOURNAL OF MEDICINE
- Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches
- (2016) Wen-Juan Huang et al. Oncology Letters
- A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient
- (2016) Hao Sun et al. Frontiers in Pharmacology
- Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma
- (2016) Mahua Dey et al. Stem Cell Reports
- Intranasal Drug Delivery: How, Why and What for?
- (2016) Anaísa Pires et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Opportunities and Challenges for the Nasal Administration of Nanoemulsions
- (2015) Claurice Comfort et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery
- (2015) Maha Nasr DRUG DELIVERY
- Overcoming the blood–brain tumor barrier for effective glioblastoma treatment
- (2015) O. van Tellingen et al. DRUG RESISTANCE UPDATES
- Rhein: A Review of Pharmacological Activities
- (2015) Yan-Xi Zhou et al. Evidence-based Complementary and Alternative Medicine
- Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration
- (2015) Jeffrey J Lochhead et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Impact of Timing of Concurrent Chemoradiation for Newly Diagnosed Glioblastoma
- (2015) Seunggu J. Han et al. NEUROSURGERY
- Improving drug biological effects by encapsulation into polymeric nanocapsules
- (2015) Luiza A. Frank et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- In situ nasal gel drug delivery: A novel approach for brain targeting through the mucosal membrane
- (2015) Prabhjot Kaur et al. Artificial Cells Nanomedicine and Biotechnology
- Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment
- (2015) D S Quintana et al. Translational Psychiatry
- Methotrexate-loaded microspheres for nose to brain delivery: in vitro/in vivo evaluation
- (2015) Yu Sun et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Teriflunomide (Leflunomide) Promotes Cytostatic, Antioxidant, and Apoptotic Effects in Transformed Prostate Epithelial Cells: Evidence Supporting a Role for Teriflunomide in Prostate Cancer Chemoprevention
- (2015) Numsen Hail et al. NEOPLASIA
- High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
- (2014) R. Stupp et al. ANNALS OF ONCOLOGY
- Epidemiologic and Molecular Prognostic Review of Glioblastoma
- (2014) J. P. Thakkar et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction
- (2014) R A Morshed et al. CANCER GENE THERAPY
- Development and evaluation of carboplatin-loaded PCL nanoparticles for intranasal delivery
- (2014) Angel Treasa Alex et al. DRUG DELIVERY
- Teriflunomide and Its Mechanism of Action in Multiple Sclerosis
- (2014) Amit Bar-Or et al. DRUGS
- Kaempferol, a potential cytostatic and cure for inflammatory disorders
- (2014) Peramaiyan Rajendran et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Featured Article: Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells
- (2014) Ou Huang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Advances in stem cells, induced pluripotent stem cells, and engineered cells: delivery vehicles for anti-glioma therapy
- (2014) Jacob S Young et al. Expert Opinion on Drug Delivery
- EphA3 biology and cancer
- (2014) Peter W. Janes et al. GROWTH FACTORS
- Inhibition of glioma progression by a newly discovered CD38 inhibitor
- (2014) Eran Blacher et al. INTERNATIONAL JOURNAL OF CANCER
- Chitosan in nasal delivery systems for therapeutic drugs
- (2014) Luca Casettari et al. JOURNAL OF CONTROLLED RELEASE
- Functional Nanoparticles in Targeting Glioma Diagnosis and Therapies
- (2014) Minghui Li et al. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma
- (2014) Michael Weller et al. LANCET ONCOLOGY
- Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain with Cell-Penetrating Peptide-Modified Micelles
- (2014) Takanori Kanazawa et al. MOLECULAR PHARMACEUTICS
- A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
- (2014) Mark R. Gilbert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
- (2014) Olivier L. Chinot et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models Towards Therapeutic Significance
- (2014) David J. Mc Carthy et al. PHARMACEUTICAL RESEARCH
- Physiology and pharmacology of melatonin in relation to biological rhythms
- (2014) Jolanta B. Zawilska et al. Pharmacological Reports
- A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis
- (2013) Samira Sadat Abolmaali et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Temozolomide-Mediated DNA Methylation in Human Myeloid Precursor Cells: Differential Involvement of Intrinsic and Extrinsic Apoptotic Pathways
- (2013) H. Wang et al. CLINICAL CANCER RESEARCH
- Poly(ϵ-caprolactone) microcapsules and nanocapsules in drug delivery
- (2013) Adriana Raffin Pohlmann et al. Expert Opinion on Drug Delivery
- Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood–brain barrier divide
- (2013) Ann-Marie Chacko et al. Expert Opinion on Drug Delivery
- A Preclinical Evaluation of Neural Stem Cell–Based Cell Carrier for Targeted Antiglioma Oncolytic Virotherapy
- (2013) Atique U. Ahmed et al. JNCI-Journal of the National Cancer Institute
- Human umbilical cord mesenchymal stem cells inhibit C6 glioma growth via secretion of dickkopf-1 (DKK1)
- (2013) Shanshan Ma et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors
- (2013) Irina V Balyasnikova et al. MOLECULAR THERAPY
- Nanotherapeutic approaches for brain cancer management
- (2013) Laura Saenz del Burgo et al. Nanomedicine-Nanotechnology Biology and Medicine
- Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies
- (2013) K. S. Aboody et al. Science Translational Medicine
- Therapeutic applications of melatonin
- (2013) Ifigenia Kostoglou-Athanassiou Therapeutic Advances in Endocrinology and Metabolism
- Stem cell-based therapy for malignant glioma
- (2012) Daniel Bexell et al. CANCER TREATMENT REVIEWS
- The Definition of Primary and Secondary Glioblastoma
- (2012) H. Ohgaki et al. CLINICAL CANCER RESEARCH
- Recent advances in brain tumor-targeted nano-drug delivery systems
- (2012) Yu Liu et al. Expert Opinion on Drug Delivery
- Phase III Trial of Chemoradiotherapy for Anaplastic Oligodendroglioma: Long-Term Results of RTOG 9402
- (2012) Gregory Cairncross et al. JOURNAL OF CLINICAL ONCOLOGY
- Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion
- (2012) L Toussaint et al. Molecular Cancer
- Intranasal Treatment of Central Nervous System Dysfunction in Humans
- (2012) Colin D. Chapman et al. PHARMACEUTICAL RESEARCH
- Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma
- (2012) Matthias Reitz et al. Stem Cells Translational Medicine
- Anatomical and Histological Factors Affecting Intranasal Drug and Vaccine Delivery
- (2012) Sveinbjorn Gizurarson Current Drug Delivery
- Intranasal delivery of biologics to the central nervous system
- (2011) Jeffrey J. Lochhead et al. ADVANCED DRUG DELIVERY REVIEWS
- Recent advancements in multimodality treatment of gliomas
- (2011) Mersiha Hadziahmetovic et al. Future Oncology
- ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats
- (2011) Xiao-Dong Cong et al. INFLAMMATION
- A Review on the Dietary Flavonoid Kaempferol
- (2011) J. M. Calderon-Montano et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- A Comparative Study of Neural and Mesenchymal Stem Cell-Based Carriers for Oncolytic Adenovirus in a Model of Malignant Glioma
- (2011) Atique U. Ahmed et al. MOLECULAR PHARMACEUTICS
- Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration
- (2011) Takanori Kanazawa et al. PHARMACEUTICAL RESEARCH
- Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats
- (2010) Zhi-peng Chen et al. FITOTERAPIA
- Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution
- (2010) Driton Vllasaliu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma
- (2010) Clovis O. da Fonseca et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Bevacizumab and Recurrent Malignant Gliomas: A European Perspective
- (2010) Wolfgang Wick et al. JOURNAL OF CLINICAL ONCOLOGY
- Transnasal Delivery of Methotrexate to Brain Tumors in Rats: A New Strategy for Brain Tumor Chemotherapy
- (2010) Tomotaka Shingaki et al. MOLECULAR PHARMACEUTICS
- Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model
- (2009) Andressa Bernardi et al. CANCER LETTERS
- Mesenchymal Stem Cell Homing: The Devil Is in the Details
- (2009) Jeffrey M. Karp et al. Cell Stem Cell
- Targeting Rat Brainstem Glioma Using Human Neural Stem Cells and Human Mesenchymal Stem Cells
- (2009) D.-H. Lee et al. CLINICAL CANCER RESEARCH
- Intranasal delivery of cells to the brain
- (2009) Lusine Danielyan et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid)
- (2009) Tomotaka Shingaki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Nanoparticles for direct nose-to-brain delivery of drugs
- (2009) Alpesh Mistry et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
- (2009) Shyeilla V. Dhuria et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1
- (2009) Y Zhu et al. LEUKEMIA
- Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma
- (2009) Andrea Pirzkall et al. NEURO-ONCOLOGY
- Genetic Epidemiology of Glioblastoma Multiforme: Confirmatory and New Findings from Analyses of Human Leukocyte Antigen Alleles and Motifs
- (2009) Wei Song et al. PLoS One
- Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
- (2008) Ling Qiao et al. CANCER LETTERS
- Drug delivery to brain tumors
- (2008) Jaishri Blakeley Current Neurology and Neuroscience Reports
- New Derivatives of Farnesylthiosalicylic Acid (Salirasib) for Cancer Treatment: Farnesylthiosalicylamide Inhibits Tumor Growth in Nude Mice Models
- (2008) Liat Goldberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation
- (2008) Luci Bavaresco et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
- (2008) Clovis Orlando da Fonseca et al. SURGICAL NEUROLOGY
- Mechanisms of Disease: temozolomide and glioblastoma—look to the future
- (2008) Maciej M Mrugala et al. Nature clinical practice. Oncology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation