Article
Clinical Neurology
Sebastiano Bucello, Pietro Annovazzi, Paolo Ragonese, Marta Altieri, Valeria Barcella, Roberto Bergamaschi, Alessia Bianchi, Giovanna Borriello, Maria Chiara Buscarinu, Graziella Callari, Marco Capobianco, Fioravante Capone, Paola Cavalla, Rosella Cavarretta, Antonio Cortese, Giovanna De Luca, Massimiliano Di Filippo, Vincenzo Dattola, Roberta Fantozzi, Elisabetta Ferraro, Maria Maddalena Filippi, Claudio Gasperini, Luigi Maria Edoardo Grimaldi, Doriana Landi, Marianna Lo Re, Giulia Mallucci, Paolo Manganotti, Girolama Alessandra Marfia, Massimiliano Mirabella, Paola Perini, Marco Pisa, Sabrina Realmuto, Margherita Russo, Valentina Tomassini, Valentina Liliana Adriana Torri-Clerici, Mauro Zaffaroni, Cristina Zuliani, Sofia Zywicki, Massimo Filippi, Luca Prosperini
Summary: Baseline factors associated with disease activity in patients with RRMS under teriflunomide treatment were identified in this study, with the most important factor being an EDSS > 4.0. The study suggests a place-in-therapy for teriflunomide in naive patients with mild disability level or in those who switched their initial treatment for poor tolerability. Adverse events related with teriflunomide were consistent with literature data, without any new safety concern.
JOURNAL OF NEUROLOGY
(2021)
Article
Pediatrics
Julia Paik
Summary: Teriflunomide is an oral immunomodulatory agent developed by Sanofi for treating multiple sclerosis, and recently received approval in the EU for pediatric patients aged >= 10 years. This marks a significant milestone in the development of teriflunomide for relapsing-remitting MS in children.
Article
Clinical Neurology
Mehmet Fatih Yetkin, Nur Aleyna Yetkin, Merve Akcakoyunlu, Meral Mirza
Summary: A multiple sclerosis patient treated with teriflunomide did not interrupt treatment during a COVID-19 infection, resulting in a mild course of infection. It may be considered that teriflunomide is a safe disease-modifying treatment option during the pandemic, as observed in this case.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Ludwig Kappos, Robert J. Fox, Michel Burcklen, Mark S. Freedman, Eva K. Havrdova, Brian Hennessy, Reinhard Hohlfeld, Fred Lublin, Xavier Montalban, Carlo Pozzilli, Tatiana Scherz, Daniele D'Ambrosio, Philippe Linscheid, Andrea Vaclavkova, Magdalena Pirozek-Lawniczek, Hilke Kracker, Till Sprenger
Summary: In the OPTIMUM trial, ponesimod showed superiority over teriflunomide in reducing annualized relapse rate, fatigue, MRI activity, brain volume loss, and NEDA status, but not in confirmed disability accumulation. The safety profile was consistent with previous observations and known S1P receptor modulators.
Review
Cell Biology
Stefanie Fischer, Undine Proschmann, Katja Akguen, Tjalf Ziemssen
Summary: While the detailed pathogenesis of multiple sclerosis (MS) remains unclear, a range of disease-modifying therapies (DMTs) are available. A common side effect of almost every MS therapeutic agent is lymphopenia, which can have both beneficial and limiting effects on treatment. Understanding the mechanism of action of the selected agent is essential for comprehending treatment-associated changes in white blood cell counts and monitoring outcomes.
Article
Clinical Neurology
L. Lorefice, S. Pilotto, G. Fenu, P. Cimino, D. Firinu, J. Frau, F. Murgia, G. Coghe, E. Cocco
Summary: The study describes the evolution of teriflunomide use in the clinical setting, particularly for naive patients and young women. Predictors of treatment response were investigated, revealing that lower baseline age, lower EDSS score, and lower ARR prior to teriflunomide treatment were associated with achievement of treatment goals.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Maria Inmaculada Dominguez-Mozo, Ines Gonzalez-Suarez, Luisa Maria Villar, Lucienne Costa-Frossard, Noelia Villarrubia, Yolanda Aladro, Belen Pilo, Xavier Montalban, Manuel Comabella, Ignacio Casanova-Peno, Maria Luisa Martinez-Gines, Jose Manuel Garcia-Dominguez, Maria Angel Garcia-Martinez, Rafael Arroyo, Roberto Alvarez-Lafuente
Summary: Treatment with teriflunomide reduced IgG antibody titers against EBV and HHV-6. Higher levels of EBNA-1 IgG prior to teriflunomide initiation were associated with a better clinical response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Jannis Muller, Sabine Schadelin, Johannes Lorscheider, Pascal Benkert, Peter Hanni, Jurg Schmid, Jens Kuhle, Tobias Derfuss, Cristina Granziera, Ozgur Yaldizli
Summary: This study compared the effectiveness of dimethyl fumarate (DMF) and teriflunomide in a real-world setting and found that DMF treatment was associated with better clinical outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yao Zhang, Hexiang Yin, Dingding Zhang, Yan Xu, Bin Peng, Liying Cui
Summary: This study aimed to explore the efficacy, risk factors, safety, and persistence of teriflunomide in patients with relapsing-remitting multiple sclerosis (RRMS). The results showed that teriflunomide was effective and well-tolerated in treatment-naive RRMS patients. Male patients with high relapse rates and disability before treatment were more likely to experience treatment failure.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Steffen Pfeuffer, Laura Kerschke, Tobias Ruck, Leoni Rolfes, Marc Pawlitzki, Philipp Albrecht, Heinz Wiendl, Sven G. Meuth
Summary: This study demonstrated that TRF treatment is associated with favorable outcomes in terms of functional optic nerve recovery following optic neuritis (ON) in early multiple sclerosis. Compared to IFN or GLAT, TRF-treated patients showed higher LCLA and shorter P100 latency, indicating better visual function recovery.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Urology & Nephrology
Anne-Sofie Greve, Sivagini Prakash, Soren Krag, Else Randers
Summary: A male patient with multiple sclerosis (MS) developed kidney disease and proteinuria during therapy with Ocrelizumab. Kidney biopsy revealed focal segmental glomerulosclerosis (FSGS). This case suggests a potential association between Ocrelizumab therapy and the development of FSGS.
JOURNAL OF NEPHROLOGY
(2023)
Review
Clinical Neurology
Carlo Tornatore, Heinz Wiendl, Alex L. Lublin, Svend S. Geertsen, Jeffrey Chavin, Philippe Truffinet, Amit Bar-Or
Summary: The efficacy and safety of COVID-19 vaccines for MS patients receiving DMTs are still under investigation, with varying results from studies on different DMTs' impact on vaccine response. Guidance currently suggests continuing DMTs during vaccination, with potential adjustments to dosing schedules for improved vaccine response.
FRONTIERS IN NEUROLOGY
(2022)
Letter
Clinical Neurology
Geraldine Luetic, Maria L. Menichini, Marcos Burgos, Ricardo Alonso, Edgar Carnero Contentti, Adriana Carra, Norma Deri, Judith Steinberg, Juan I. Rojas
Summary: The study reported the COVID-19 outcomes in multiple sclerosis patients treated with teriflunomide in Argentina, showing that the infection was mild in these patients, and continuing with teriflunomide treatment did not lead to MS relapses.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Gaelle Tilly, Marion Cadoux, Alexandra Garcia, Jeremy Morille, Sandrine Wiertlewski, Claire Pecqueur, Sophie Brouard, David Laplaud, Nicolas Degauque
Summary: The study found that 12 months of treatment with teriflunomide in patients with RRMS did not affect B cell or CD4 T cell compartments, but had a specific impact on CD8 T cells, including decreased proliferation and reduced production of inflammatory factors. DHODH inhibition also affected the migratory velocity of memory CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Jerome de Seze, Richard Devy, Evelyne Planque, Jean Philippe Delabrousse-Mayoux, Olivier Vandhuick, Marmar Kabir, Amel Gherib
Summary: The study found that fatigue levels remained stable in relapsing remitting MS patients treated with Teriflunomide in real-world practice, and there were no negative impacts on depression or quality of life.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Johanna Breuer, Sebastian Herich, Tilman Schneider-Hohendorf, Achmet Chasan, Nina Wettschureck, Catharina C. Gross, Karin Loser, Alexander Zarbock, Johannes Roth, Luisa Klotz, Heinz Wiendl, Nicholas Schwab
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Clinical Neurology
Gavin Giovannoni, Heinz Wiendl, Benjamin Turner, Kimberly Umans, Oksana Mokliatchouk, Wanda Castro-Borrero, Steven J. Greenberg, Peter McCroskery, Giorgio Giannattasio
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Clinical Neurology
Stanley Cohan, Ludwig Kappos, Gavin Giovannoni, Heinz Wiendl, Krzysztof Selmaj, Eva Kubala Havrdova, John Rose, Steven Greenberg, Glenn Phillips, Wei Ma, Ping Wang, Gabriel Lima, Guido Sabatella
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Clinical Neurology
Stefan T. Gerner, Joji B. Kuramatsu, Jochen A. Sembill, Maximilian I. Spruegel, Matthias Endres, Karl Georg Haeusler, Peter Vajkoczy, Peter A. Ringleb, Jan Purrucker, Timolaos Rizos, Frank Erbguth, Peter D. Schellinger, Gereon R. Fink, Henning Stetefeld, Hauke Schneider, Hermann Neugebauer, Joachim Roether, Joseph Classen, Dominik Michalski, Arnd Doerfler, Stefan Schwab, Hagen B. Huttner
ANNALS OF NEUROLOGY
(2018)
Review
Immunology
Ali Maisam Afzali, Thomas Muentefering, Heinz Wiendl, Sven G. Meuth, Tobias Ruck
AUTOIMMUNITY REVIEWS
(2018)
Article
Clinical Neurology
X. Montalban, R. Gold, A. J. Thompson, S. Otero-Romero, M. P. Amato, D. Chandraratna, M. Clanet, G. Comi, T. Derfuss, F. Fazekas, H. P. Hartung, E. Havrdova, B. Hemmer, L. Kappos, R. Liblau, C. Lubetzki, E. Marcus, D. H. Miller, T. Olsson, S. Pilling, K. Selmaj, A. Siva, P. S. Sorensen, M. P. Sormani, C. Thalheim, H. Wiendl, F. Zipp
EUROPEAN JOURNAL OF NEUROLOGY
(2018)
Review
Biochemistry & Molecular Biology
Maren Lindner, Luisa Klotz, Heinz Wiendl
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Medicine, General & Internal
Ludwig Kappos, Amit Bar-Or, Bruce A. C. Cree, Robert J. Fox, Gavin Giovannoni, Ralf Gold, Patrick Vermersch, Douglas L. Arnold, Sophie Arnould, Tatiana Scherz, Christian Wolf, Erik Wallstroem, Frank Dahlke
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Clinical Neurology
Christiane Graetz, Adriane Groeger, Felix Luessi, Anke Salmen, Daniela Zoeller, Janine Schultz, Nelly Siller, Vinzenz Fleischer, Barbara Bellenberg, Achim Berthele, Viola Biberacher, Joachim Havla, Michael Hecker, Reinhard Hohlfeld, Carmen Infante-Duarte, Jan S. Kirschke, Tania Kuempfel, Ralf Linker, Friedemann Paul, Steffen Pfeuffer, Philipp Saemann, Gerrit Toenges, Frank Weber, Uwe K. Zettl, Antje Jahn-Eimermacher, Gisela Antony, Sergiu Groppa, Heinz Wiendl, Bernhard Hemmer, Mark Muehlau, Carsten Lukas, Ralf Gold, Christina M. Lill, Frauke Zipp
MULTIPLE SCLEROSIS JOURNAL
(2019)
Article
Clinical Neurology
Xavier Montalban, Ralf Gold, Alan J. Thompson, Susana Otero-Romero, Maria Pia Amato, Dhia Chandraratna, Michel Clanet, Giancarlo Comi, Tobias Derfuss, Franz Fazekas, Hans Peter Hartung, Eva Havrdova, Bernhard Hemmer, Ludwig Kappos, Roland Liblau, Catherine Lubetzki, Elena Marcus, David H. Miller, Tomas Olsson, Steve Pilling, Krysztof Selmaj, Axel Siva, Per Soelberg Sorensen, Maria Pia Sormani, Christoph Thalheim, Heinz Wiendl, Frauke Zipp
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Geriatrics & Gerontology
Matthias Pawlowski, Gero Lueg, Catharina C. Gross, Andreas Johnen, Julia Kraemer, Matthias Weckesser, Heinz Wiendl, Sven G. Meuth, Thomas Duning
NEUROBIOLOGY OF AGING
(2018)
Editorial Material
Clinical Neurology
Heinz Wiendl, Peter A. Calabresi, Sven G. Meuth
Article
Multidisciplinary Sciences
Tilman Schneider-Hohendorf, Dennis Goerlich, Paula Savola, Tiina Kelkka, Satu Mustjoki, Catharina C. Gross, Geoffrey C. Owens, Luisa Klotz, Klaus Dornmair, Heinz Wiendl, Nicholas Schwab
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Clinical Neurology
Christiane Graetz, Adriane Groeger, Felix Luessi, Anke Salmen, Daniela Zoeller, Janine Schultz, Nelly Siller, Vinzenz Fleischer, Barbara Bellenberg, Achim Berthele, Viola Biberacher, Joachim Havla, Michael Hecker, Reinhard Hohlfeld, Carmen Infante-Duarte, Jan S. Kirschke, Tania Kuempfel, Ralf Linker, Friedemann Paul, Steffen Pfeuffer, Philipp Saemann, Gerrit Toenges, Frank Weber, Uwe K. Zettl, Antje Jahn-Eimermacher, Gisela Antony, Sergiu Groppa, Heinz Wiendl, Bernhard Hemmer, Mark Muehlau, Carsten Lukas, Ralf Gold, Christina M. Lill, Frauke Zipp
MULTIPLE SCLEROSIS JOURNAL
(2019)
Article
Clinical Neurology
Olga von Bismarck, Theresa Dankowski, Bjeorn Ambrosius, Nicole Hessler, Gisela Antony, Andreas Ziegler, Muna-Miriam Hoshi, Lilian Aly, Felix Luessi, Sergiu Groppa, Luisa Klotz, Sven G. Meuth, Bjorn Tackenberg, Muriel Stoppe, Florian Then Bergh, Hayrettin Tumani, Tania Kuempfel, Martin Stangel, Christoph Heesen, Brigitte Wildemann, Friedemann Paul, Antonios Bayas, Clemens Warnke, Frank Weber, Ralf A. Linker, Ulf Ziemann, Uwe K. Zettl, Frauke Zipp, Heinz Wiendl, Bernhard Hemmer, Ralf Gold, Anke Salmen
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2018)