A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

Liposomes loaded with lipophilic prodrugs of methotrexate and melphalan as convenient drug delivery vehicles

(2015) N. Kuznetsova et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Methotrexate-loaded microspheres for nose to brain delivery: in vitro/in vivo evaluation

(2015) Yu Sun et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio

(2012) Hong Zong et al.   BIOMACROMOLECULES

Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery

(2012) Amir Azadi et al.   CARBOHYDRATE POLYMERS

Trastuzumab decorated methotrexate–human serum albumin conjugated nanoparticles for targeted delivery to HER2 positive tumor cells

(2012) Azade Taheri et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Investigation of nano lipid vesicles of methotrexate for anti-rheumatoid activity

(2012) Prabhakara Prabhu et al.   International Journal of Nanomedicine

The in vivo antitumor activity of LHRH targeted methotrexate–human serum albumin nanoparticles in 4T1 tumor-bearing Balb/c mice

(2012) Azade Taheri et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate

(2012) Seok Ki Choi et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Methotrexate-Loaded Chitosan- and Glycolchitosan-Based Nanoparticles: A Promising Strategy for the Administration of the Anticancer Drug to Brain Tumors

(2011) Adriana Trapani et al.   AAPS PHARMSCITECH

Injectable thermosensitive hydrogels for intra-articular delivery of methotrexate

(2011) Bolong Miao et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Targeted Delivery of Methotrexate to Tumor Cells Using Biotin Functionalized Methotrexate-Human Serum Albumin Conjugated Nanoparticles

(2011) Azade Taheri et al.   Journal of Biomedical Nanotechnology

Lactoferrin-Conjugated Dendritic Nanoconstructs for Lung Targeting of Methotrexate

(2011) Balak D. Kurmi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Methotrexate-incorporated polymeric micelles composed of methoxy poly(ethylene glycol)-grafted chitosan

(2011) Young-Il Jeong et al.   MACROMOLECULAR RESEARCH

Synthesis, pharmacoscintigraphic evaluation and antitumor efficacy of methotrexate-loaded, folate-conjugated, stealth albumin nanoparticles

(2011) Sanyog Jain et al.   Nanomedicine

Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery

(2011) Jingou Ji et al.   POLYMER BULLETIN

Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells

(2010) Zhiqian Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Characterization of Methotrexate Polyethylene Glycol Esters as a Drug Delivery System

(2010) Gholamhossein Yousefi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Differential effects of methotrexate and liposomally conjugated methotrexate in rat adjuvant-induced arthritis

(2010) A. S. WILLIAMS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Nanoparticles of Conjugated Methotrexate-Human Serum Albumin: Preparation and Cytotoxicity Evaluations

(2010) Azade Taheri et al.   Journal of Nanomaterials

Capping Methotrexate α-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers

(2010) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

Novel hyaluronic acid–methotrexate conjugates for osteoarthritis treatment

(2009) Akie Homma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and optimization of hyaluronic acid–methotrexate conjugates to maximize benefit in the treatment of osteoarthritis

(2009) Akie Homma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers

(2009) Cristian Samorì et al.   CHEMICAL COMMUNICATIONS

A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system

(2009) Xiaoyu Zhang et al.   DRUG DELIVERY

Determining the cytotoxicity of methotrexate-loaded microemulsion on human breast, ovarian, and prostate carcinoma cell lines: a new modality for an old drug

(2009) H.Y. Karasulu et al.   DRUG DEVELOPMENT RESEARCH

Slow release properties and liver-targeting characteristics of methotrexate erythrocyte carriers

(2009) Sheng-Hua Yuan et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers

(2009) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

Targeted drug delivery by in vivo coupling to endogenous albumin: an albumin-binding prodrug of methotrexate (MTX) is better than MTX in the treatment of murine collagen-induced arthritis

(2008) C Fiehn et al.   ANNALS OF THE RHEUMATIC DISEASES

Polyethylene Glycol Conjugates of Methotrexate and Melphalan: Synthesis, Radiolabeling and Biologic Studies

(2008) Gauri Shukla et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

The Effect of Chitosan Molecular Weight on the Characteristics of Spray-Dried Methotrexate-Loaded Chitosan Microspheres for Nasal Administration

(2008) Yu Sun et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Drug delivery systems for the treatment of rheumatoid arthritis

(2008) Ingo H Tarner et al.   Expert Opinion on Drug Delivery

Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes

(2008) Lin Zhu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Methotrexate Loaded Polyether-Copolyester Dendrimers for the Treatment of Gliomas: Enhanced Efficacy and Intratumoral Transport Capability

(2008) Renu Singh Dhanikula et al.   MOLECULAR PHARMACEUTICS

HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb

(2008) Rameshwer Shukla et al.   NANOTECHNOLOGY