Featured Article: Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells

Teriflunomide (Leflunomide) Promotes Cytostatic, Antioxidant, and Apoptotic Effects in Transformed Prostate Epithelial Cells: Evidence Supporting a Role for Teriflunomide in Prostate Cancer Chemoprevention

(2015) Numsen Hail et al.   NEOPLASIA

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A771726, an anti-inflammatory drug, exerts an anticancer effect and reverses tamoxifen resistance in endocrine-resistant breast cancer cells

(2014) OU HUANG et al.   ONCOLOGY REPORTS

Triple-Negative Breast Cancer and the Need for New Therapeutic Targets

(2013) Olav Engebraaten et al.   AMERICAN JOURNAL OF PATHOLOGY

Safety, Tolerability, and Efficacy of Oral Therapies for Relapsing-Remitting Multiple Sclerosis

(2013) Jiwon Oh et al.   CNS DRUGS

Drugs in Development for Relapsing Multiple Sclerosis

(2013) Rehiana Ali et al.   DRUGS

Pharmacokinetic evaluation of teriflunomide for the treatment of multiple sclerosis

(2013) Michael D Wiese et al.   Expert Opinion on Drug Metabolism & Toxicology

Randomized Phase II Study of the Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Cetuximab With Cisplatin Versus Cisplatin Alone in Patients With Metastatic Triple-Negative Breast Cancer

(2013) José Baselga et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic targets in triple negative breast cancer

(2013) Sandra A O'Toole et al.   JOURNAL OF CLINICAL PATHOLOGY

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer

(2013) A. Prat et al.   ONCOLOGIST

Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors

(2013) Z. Castano et al.   Cancer Discovery

Triple-negative breast cancer: epidemiological considerations and recommendations

(2012) P. Boyle   ANNALS OF ONCOLOGY

Matrix Metalloproteinase 9 (MMP-9)-dependent Processing of βig-h3 Protein Regulates Cell Migration, Invasion, and Adhesion

(2012) Yeon Hyang Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

(2012) Dai Horiuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro

(2012) Yash Somnay et al.   NEUROENDOCRINOLOGY

The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells

(2012) Edmond F. O’Donnell et al.   PLoS One

Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes

(2011) Numsen Hail et al.   APOPTOSIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Leflunomide Induces Apoptosis in Fludarabine-Resistant and Clinically Refractory CLL Cells

(2011) S. Dietrich et al.   CLINICAL CANCER RESEARCH

Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells

(2011) Tsung-Ying Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

Molecular Stratification of Triple-Negative Breast Cancers

(2011) C. M. Perou   ONCOLOGIST

Teriflunomide encourages cytostatic and apoptotic effects in premalignant and malignant cutaneous keratinocytes

(2010) Numsen Hail et al.   APOPTOSIS

Epidermal Growth Factor Receptor in Triple-Negative and Basal-Like Breast Cancer

(2010) Monika L. Burness et al.   CANCER JOURNAL

Identification of a Novel Raf-1 Pathway Activator that Inhibits Gastrointestinal Carcinoid Cell Growth

(2010) M. R. Cook et al.   MOLECULAR CANCER THERAPEUTICS

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

Zoledronic acid determines S-phase arrest but fails to induce apoptosis in cholangiocarcinoma cells

(2009) Antonello A. Romani et al.   BIOCHEMICAL PHARMACOLOGY

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells

(2009) P. Baumann et al.   MOLECULAR CANCER THERAPEUTICS