ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein

(2011) Guo-lin Zhang et al.   ACTA PHARMACOLOGICA SINICA

Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice

(2011) Xiaoyan Sheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis

(2011) Xiao Li Huang et al.   INFLAMMATION RESEARCH

Selective Abrogation of BiP/GRP78 Blunts Activation of NF- B through the ATF6 Branch of the UPR: Involvement of C/EBP  and mTOR-Dependent Dephosphorylation of Akt

(2011) S. Nakajima et al.   MOLECULAR AND CELLULAR BIOLOGY

Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue

(2011) C. Hu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease

(2010) Damir Hamamdzic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A20 suppresses inflammatory responses and bone destruction in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis

(2010) Young-Sool Hah et al.   ARTHRITIS AND RHEUMATISM

The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol

(2010) Hong-Jun Peng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo

(2010) Ming-Hsing Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

(2010) Debra M Meyer et al.   Journal of Inflammation-London

Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shcSignaling Cascade: Counter Regulation by Estrogens or Androgens

(2010) Maria Almeida et al.   MOLECULAR ENDOCRINOLOGY

Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats

(2010) Martina Skurlova et al.   NEUROSCIENCE LETTERS

Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes

(2010) A.W.M. Cheng et al.   OSTEOARTHRITIS AND CARTILAGE

Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei

(2010) Zhi-Heng He et al.   PHYTOMEDICINE

Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

(2009) N. Wehling et al.   ARTHRITIS AND RHEUMATISM

Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats

(2009) A Bernardi et al.   BRITISH JOURNAL OF PHARMACOLOGY

PIKKing on PKB: regulation of PKB activity by phosphorylation

(2009) Lana Bozulic et al.   CURRENT OPINION IN CELL BIOLOGY

Renal adverse effects of nonsteroidal anti-inflammatory drugs

(2009) Sam Harirforoosh et al.   Expert Opinion On Drug Safety

Diacerein decreases TNF-α and IL-1β levels in peritoneal fluid and prevents Baker’s yeast-induced fever in young rats

(2009) Juliana Saibt Martins Pasin et al.   INFLAMMATION RESEARCH

Imatinib mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference with the Akt signaling pathway

(2009) Fumitaka Terabe et al.   Modern Rheumatology

Rhein Improves Renal Lesion and Ameliorates Dyslipidemia in db/db Mice with Diabetic Nephropathy

(2009) Qing Gao et al.   PLANTA MEDICA

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway

(2008) J-M Zheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation

(2008) Na Li et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The chemical biology of nitric oxide — an outsider's reflections about its role in osteoarthritis

(2008) Martin Feelisch   OSTEOARTHRITIS AND CARTILAGE

Anti-inflammatory and analgesic effects and molecular mechanisms of JCICM-6, a purified extract derived from an anti-arthritic Chinese herbal formula

(2008) Y.F. Wong et al.   PHYTOMEDICINE

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

(2008) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY

Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22Phox and iNOS expression

(2007) C. Valvason et al.   RHEUMATOLOGY