标题
Pleiotropic Effects of mTOR and Autophagy During Development and Aging
作者
关键词
-
出版物
Frontiers in Cell and Developmental Biology
Volume 7, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-09-11
DOI
10.3389/fcell.2019.00192
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Influence of Normal Aging on Brain Autophagy: A Complex Scenario
- (2019) David A. Loeffler Frontiers in Aging Neuroscience
- Suppression of autophagic activity by Rubicon is a signature of aging
- (2019) Shuhei Nakamura et al. Nature Communications
- Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging
- (2019) Jianjian Shi et al. FASEB JOURNAL
- Autophagy and cardiac aging
- (2019) Shigeki Miyamoto CELL DEATH AND DIFFERENTIATION
- Autophagy regulates lipid metabolism through selective turnover of NCoR1
- (2019) Tetsuya Saito et al. Nature Communications
- Autophagy in health and disease: A comprehensive review
- (2018) Sarbari Saha et al. BIOMEDICINE & PHARMACOTHERAPY
- Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers
- (2018) Chengcheng Li et al. EXPERIMENTAL GERONTOLOGY
- Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training
- (2018) Maja Munk Dethlefsen et al. EXPERIMENTAL GERONTOLOGY
- Rapamycin confers neuroprotection against aging-induced oxidative stress, mitochondrial dysfunction and neurodegeneration in old rats via activation of autophagy
- (2018) Abhishek Kumar Singh et al. REJUVENATION RESEARCH
- Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
- (2018) Dagmar E. Ehrnhoefer et al. Acta Neuropathologica Communications
- Autophagy in Human Skin Fibroblasts: Impact of Age
- (2018) Hei Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging
- (2018) Michael D. Arensman et al. MOLECULAR CELL
- Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy
- (2018) Kathrin Schmeisser et al. PLoS Genetics
- Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury
- (2018) Mingxia Zhou et al. EBioMedicine
- Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
- (2018) Kurt A. Escobar et al. AGING CELL
- C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies
- (2018) Marina Ezcurra et al. CURRENT BIOLOGY
- Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans
- (2017) Thomas Wilhelm et al. GENES & DEVELOPMENT
- The ubiquity of pleiotropy in human disease
- (2017) Kevin Chesmore et al. HUMAN GENETICS
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway
- (2017) Jingjing Fan et al. Oncotarget
- Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging
- (2017) Jessica T Chang et al. eLife
- Antagonistic pleiotropy and mutation accumulation influence human senescence and disease
- (2017) Juan Antonio Rodríguez et al. Nature Ecology & Evolution
- Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
- (2016) Amiya Kumar Ghosh et al. Aging-US
- Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging
- (2016) Laura García-Prat et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation
- (2016) Sang Su Kwak et al. CELLULAR SIGNALLING
- AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
- (2016) Nathan P. Young et al. GENES & DEVELOPMENT
- Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects
- (2016) H-J Kim et al. MOLECULAR PSYCHIATRY
- AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
- (2016) Hi-Jai R. Shin et al. NATURE
- Understanding Dopaminergic Cell Death Pathways in Parkinson Disease
- (2016) Patrick P. Michel et al. NEURON
- Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro
- (2016) Carolin Walter et al. NEUROPHARMACOLOGY
- Autophagy in the eye: Development, degeneration, and aging
- (2016) Patricia Boya et al. PROGRESS IN RETINAL AND EYE RESEARCH
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts
- (2016) Christiane Ott et al. Redox Biology
- Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
- (2016) Antonio Piras et al. Acta Neuropathologica Communications
- mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
- (2016) Claudia Manzoni et al. Scientific Reports
- Tissue-specific autophagy responses to aging and stress in C. elegans
- (2015) Hannah C. Chapin et al. Aging-US
- This old heart: Cardiac aging and autophagy
- (2015) Phyllis-Jean Linton et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Autophagy in Huntington disease and huntingtin in autophagy
- (2015) Dale D.O. Martin et al. TRENDS IN NEUROSCIENCES
- Basal Level of Autophagy Is Increased in Aging Human Skin Fibroblasts In Vitro, but Not in Old Skin
- (2015) Dino Demirovic et al. PLoS One
- Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans
- (2014) Márton L. Tóth et al. Autophagy
- Autophagy is required for extension of yeast chronological life span by rapamycin
- (2014) Ashley L. Alvers et al. Autophagy
- Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A
- (2014) Sunil Laxman et al. Autophagy
- Geroconversion: irreversible step to cellular senescence
- (2014) Mikhail V Blagosklonny CELL CYCLE
- Oxidative stress and autophagy: the clash between damage and metabolic needs
- (2014) G Filomeni et al. CELL DEATH AND DIFFERENTIATION
- The C. elegans LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39
- (2014) Marion Manil-Ségalen et al. DEVELOPMENTAL CELL
- Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
- (2014) Michael Ristow et al. Dose-Response
- Assays to monitor autophagy in Drosophila
- (2014) Caroline Mauvezin et al. METHODS
- Shaping Dendritic Spines in Autism Spectrum Disorder: mTORC1-Dependent Macroautophagy
- (2014) Heather Bowling et al. NEURON
- Age-related disruption of autophagy in dermal fibroblasts modulates extracellular matrix components
- (2013) Kanae Tashiro et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A
- (2013) Benjamin M. Sutter et al. CELL
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- Autophagy has a key role in the pathophysiology of schizophrenia
- (2013) A Merenlender-Wagner et al. MOLECULAR PSYCHIATRY
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
- (2013) Francesca Nazio et al. NATURE CELL BIOLOGY
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- The age-specific force of natural selection and biodemographic walls of death
- (2013) K. W. Wachter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Neuronal autophagy and neurodegenerative diseases
- (2012) Jin H. Son et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
- (2012) Alejo Efeyan et al. NATURE
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Autophagy Dysregulation in Amyotrophic Lateral Sclerosis
- (2011) Sheng Chen et al. BRAIN PATHOLOGY
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Experimental Evolution Reveals Antagonistic Pleiotropy in Reproductive Timing but Not Life Span in Caenorhabditis elegans
- (2011) Jennifer L. Anderson et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest
- (2011) Ian G. Ganley et al. MOLECULAR CELL
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- Investigation on Huntington's disease in the Canadian Prairies
- (2010) M. H. K. Shokeir CLINICAL GENETICS
- DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy
- (2010) Itay Koren et al. CURRENT BIOLOGY
- Survival costs of reproduction in Drosophila
- (2010) Thomas Flatt EXPERIMENTAL GERONTOLOGY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- The genetics of ageing
- (2010) Cynthia J. Kenyon NATURE
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
- (2010) A. S. Tsvetkov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy and Metabolism
- (2010) J. D. Rabinowitz et al. SCIENCE
- A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors
- (2010) Mirela Matecic et al. PLoS Genetics
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- TOR-dependent control of autophagy: biting the hand that feeds
- (2009) Thomas P Neufeld CURRENT OPINION IN CELL BIOLOGY
- Age-dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy
- (2009) J. A. MOORAD et al. JOURNAL OF EVOLUTIONARY BIOLOGY
- An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation
- (2009) Yu-Yun Chang et al. MOLECULAR BIOLOGY OF THE CELL
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- Diet and longevity in the balance
- (2009) Thomas Flatt NATURE
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
- (2009) Kohichi Matsunaga et al. NATURE CELL BIOLOGY
- SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
- (2008) Xiaoju Max Ma et al. CELL
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
- (2008) S Sarkar et al. CELL DEATH AND DIFFERENTIATION
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
- (2008) Andrea Williams et al. Nature Chemical Biology
- A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
- (2008) Malene Hansen et al. PLoS Genetics
- Autophagy and aging: keeping that old broom working
- (2008) Ana Maria Cuervo TRENDS IN GENETICS
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