Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Antagonistic pleiotropy and mutation accumulation influence human senescence and disease

(2017) Juan Antonio Rodríguez et al.   Nature Ecology & Evolution

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality

(2016) Alexander M. Kulminski et al.   PLoS Genetics

Deep Proteome Analysis Identifies Age-Related Processes in C. elegans

(2016) Vikram Narayan et al.   Cell Systems

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

(2014) Masaki Mizunuma et al.   AGING CELL

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Differential Function of the Two Atg4 Homologues in the Aggrephagy Pathway inCaenorhabditis elegans

(2012) Fan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CUP-5, theC. elegansortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes

(2011) Tao Sun et al.   Autophagy

The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway inC. elegans

(2011) Peiguo Yang et al.   Autophagy

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans

(2011) Alexander Ruck et al.   Autophagy

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

Autophagy-independent LC3 function in vesicular traffic

(2010) Cornelis A.M. de Haan et al.   Autophagy

The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans

(2010) Adriana Alberti et al.   Autophagy

RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans

(2010) Z. Ni et al.   Briefings in Functional Genomics

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Genome-Wide Identification of Binding Sites Defines Distinct Functions for Caenorhabditis elegans PHA-4/FOXA in Development and Environmental Response

(2010) Mei Zhong et al.   PLoS Genetics

Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia

(2009) J.-A Lee et al.   JOURNAL OF NEUROSCIENCE

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics