标题
Geroconversion: irreversible step to cellular senescence
作者
关键词
-
出版物
CELL CYCLE
Volume 13, Issue 23, Pages 3628-3635
出版商
Informa UK Limited
发表日期
2014-11-12
DOI
10.4161/15384101.2014.985507
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density
- (2016) Yong Pan et al. Aging-US
- Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential
- (2016) Zoya N. Demidenko et al. Aging-US
- Growth and aging: a common molecular mechanism
- (2016) Mikhail V. Blagosklonny et al. Aging-US
- Validation of anti-aging drugs by treating age-related diseases
- (2016) Mikhail V. Blagosklonny Aging-US
- DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
- (2016) Olga V. Leontieva et al. Aging-US
- Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
- (2016) Mikhail V. Blagosklonny Aging-US
- The p53 inducing drug dosage may determine quiescence or senescence
- (2016) David P. Lane et al. Aging-US
- The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
- (2016) Lioubov G. Korotchkina et al. Aging-US
- Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells
- (2016) Baomin Li et al. Aging-US
- Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay
- (2016) Marco De Cecco et al. Aging-US
- Molecular damage in cancer: an argument for mTOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression
- (2016) Olga V. Leontieva et al. Aging-US
- The Werner syndrome protein: linking the replication checkpoint response to genome stability
- (2016) Pietro Pichierri et al. Aging-US
- Deciphering the role of Nuclear Factor-κB in cellular senescence
- (2016) Simon Vaughan et al. Aging-US
- Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
- (2016) Mikhail V. Blagosklonny Aging-US
- Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
- (2016) Lawrence A. Donehower Aging-US
- Answering the ultimate question “What is the Proximal Cause of Aging?”
- (2016) Mikhail V. Blagosklonny Aging-US
- Recent discoveries in the cycling, growing and aging of the p53 field
- (2016) James A. McCubrey et al. Aging-US
- Beyond average: potential for measurement of short telomeres
- (2016) Elsa Vera et al. Aging-US
- Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
- (2016) Elena A. Komarova et al. Aging-US
- Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Replicatively senescent cells are arrested in G1 and G2 phases
- (2016) Zhiyong Mao et al. Aging-US
- New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- (2016) Maria Comas et al. Aging-US
- Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
- (2016) EA Georgakopoulou et al. Aging-US
- Berberine suppresses gero-conversion from cell cycle arrest to senescence
- (2016) Hong Zhao et al. Aging-US
- Human nevi lack distinguishing senescence traits
- (2016) Sieu Tran et al. Aging-US
- How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a
- (2016) Jessie C. Jeyapalan et al. Aging-US
- MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways
- (2016) Zhaoyong Hu et al. Aging-US
- Is miR-29 an oncogene or tumor suppressor in CLL?
- (2015) Oncotarget
- Wiring the oncogenic circuitry: Pin1 unleashes mutant p53
- (2015) Oncotarget
- Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
- (2015) Weibo Luo et al. Oncotarget
- Phosphorylation of AKT: a Mutational Analysis.
- (2015) Jonathan R. Hart et al. Oncotarget
- Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
- (2015) Lydia Kriegl et al. Oncotarget
- Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
- (2015) Yuchen Jiao et al. Oncotarget
- Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine
- (2015) Kyung H Yi et al. Oncotarget
- Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer
- (2015) Leigh Ellis et al. Oncotarget
- Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy
- (2015) Frank Louwen et al. Oncotarget
- FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
- (2015) Rocky Cipriano et al. Oncotarget
- LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program
- (2015) Xing-gang Mao et al. Oncotarget
- Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved
- (2015) Maria Grazia Vizioli et al. Oncotarget
- Contact inhibition against senescence
- (2015) Peiqing Sun Oncotarget
- Caspase-2 regulates oncogene-induced senescence
- (2015) Delphine Gitenay et al. Oncotarget
- Cellular senescence and its effector programs
- (2014) R. Salama et al. GENES & DEVELOPMENT
- Geriatric muscle stem cells switch reversible quiescence into senescence
- (2014) Pedro Sousa-Victor et al. NATURE
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells
- (2014) Birgit Berkenkamp et al. PLoS One
- Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program
- (2014) O. V. Leontieva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dysregulation of the mTOR pathway in p53-deficient mice
- (2013) Olga V Leontieva et al. CANCER BIOLOGY & THERAPY
- Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
- (2013) Christin E. Burd et al. CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- mTOR in aging, metabolism, and cancer
- (2013) Marion Cornu et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
- (2013) Xing-mei Zhang et al. GENE
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence
- (2013) Yi Luo et al. TRANSPLANTATION
- TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
- (2013) M V Blagosklonny Cell Death & Disease
- A senescent cell bystander effect: senescence-induced senescence
- (2012) Glyn Nelson et al. AGING CELL
- Prospective Treatment of Age-Related Diseases by Slowing Down Aging
- (2012) Mikhail V. Blagosklonny AMERICAN JOURNAL OF PATHOLOGY
- Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
- (2012) David Gems et al. Annual Review of Physiology
- Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?
- (2012) David Gems et al. ANTIOXIDANTS & REDOX SIGNALING
- Dissecting the role of mTOR complexes in cellular senescence
- (2012) Manuel Serrano CELL CYCLE
- A new chronological survival assay in mammalian cell culture
- (2012) Matt Kaeberlein et al. CELL CYCLE
- Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
- (2012) Marina Kolesnichenko et al. CELL CYCLE
- Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells
- (2012) Olga V. Leontieva et al. CELL CYCLE
- Chronological and replicative lifespan in yeast
- (2012) Michael Polymenis et al. CELL CYCLE
- Suppression of replicative senescence by rapamycin in rodent embryonic cells
- (2012) Tatyana V. Pospelova et al. CELL CYCLE
- Replicative and Chronological Aging in Saccharomyces cerevisiae
- (2012) Valter D. Longo et al. Cell Metabolism
- Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
- (2012) Cecilia A. Hinojosa et al. EXPERIMENTAL GERONTOLOGY
- Astrocyte Senescence as a Component of Alzheimer’s Disease
- (2012) Rekha Bhat et al. PLoS One
- Hypoxia suppresses conversion from proliferative arrest to cellular senescence
- (2012) O. V. Leontieva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
- (2011) Zoya N. Demidenko et al. CELL CYCLE
- mTORC1 signaling governs hematopoietic stem cell quiescence
- (2011) Boyi Gan et al. CELL CYCLE
- Rapamycin decelerates cellular senescence
- (2011) Zoya N. Demidenko et al. CELL CYCLE
- mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging
- (2011) Javier A. Menendez et al. CELL CYCLE
- mTOR signaling in disease
- (2011) Eva Dazert et al. CURRENT OPINION IN CELL BIOLOGY
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
- (2011) Jessica J. Howell et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Growth stimulation leads to cellular senescence when the cell cycle is blocked
- (2010) Zoya N. Demidenko et al. CELL CYCLE
- Aging: ROS or TOR
- (2010) Mikhail V Blagosklonny CELL CYCLE
- Weak p53 permits senescence during cell cycle arrest
- (2010) Olga V. Leontieva et al. CELL CYCLE
- Paradoxical suppression of cellular senescence by p53
- (2010) Z. N. Demidenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
- (2010) Zhaohui Feng et al. TRENDS IN CELL BIOLOGY
- DNA damage response and cellular senescence in tissues of aging mice
- (2009) Chunfang Wang et al. AGING CELL
- mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
- (2009) Rogerio M. Castilho et al. Cell Stem Cell
- Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
- (2009) D. Adhikari et al. HUMAN MOLECULAR GENETICS
- Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension
- (2009) Min Wei et al. PLoS Genetics
- Aging, Stem Cells, and Mammalian Target of Rapamycin: A Prospect of Pharmacologic Rejuvenation of Aging Stem Cells
- (2008) Mikhail V. Blagosklonny REJUVENATION RESEARCH
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