Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance

(2018) Shylesh Bhaskaran et al.   EMBO REPORTS

The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 fromMycobacterium tuberculosis

(2018) Katharina Weinhäupl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

(2018) Siavash Vahidi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for Each

(2018) Nicholas A. Wood et al.   JOURNAL OF BACTERIOLOGY

Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes

(2017) Dóra Balogh et al.   Chemical Science

Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome

(2017) Wilfried Moreira et al.   Frontiers in Microbiology

Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, fromMycobacterium tuberculosis

(2016) Mi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease

(2016) Kirsten Famulla et al.   MOLECULAR MICROBIOLOGY

Studying dynamics by magic-angle spinning solid-state NMR spectroscopy: Principles and applications to biomolecules

(2016) Paul Schanda et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex fromListeria monocytogenes

(2015) Maria Dahmen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

Cleavage Specificity ofMycobacterium tuberculosisClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity

(2015) Tatos Akopian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

(2015) Malte Gersch et al.   Nature Communications

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

(2014) Karl R. Schmitz et al.   MOLECULAR MICROBIOLOGY

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

(2014) K. R. Schmitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helix Unfolding/Refolding Characterizes the Functional Dynamics ofStaphylococcus aureusClp Protease

(2013) Fei Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad

(2013) E. Zeiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

(2012) Tatos Akopian et al.   EMBO JOURNAL

ClpP: A structurally dynamic protease regulated by AAA+ proteins

(2012) John A. Alexopoulos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Bacterial proteolytic complexes as therapeutic targets

(2012) Ravikiran M. Raju et al.   NATURE REVIEWS DRUG DISCOVERY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

A Conformational Switch Underlies ClpP Protease Function

(2011) Sebastian R. Geiger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prediction of Hydrodynamic and Other Solution Properties of Rigid Proteins from Atomic- and Residue-Level Models

(2011) A. Ortega et al.   BIOPHYSICAL JOURNAL

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2

(2011) Nadia Benaroudj et al.   BMC BIOCHEMISTRY

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle

(2011) David M. Smith et al.   CELL

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

(2011) Elisa Leung et al.   CHEMISTRY & BIOLOGY

Structural Switching ofStaphylococcus aureusClp Protease

(2011) Jie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Directed Methyl Group Labeling as an NMR Probe of Structure and Dynamics in Supramolecular Protein Systems: Applications to the Proteasome and to the ClpP Protease

(2011) Tomasz L. Religa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

(2011) P. Sass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Control of Substrate Gating and Translocation into ClpP by Channel Residues and ClpX Binding

(2010) Mary E. Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development

(2010) Sumit Rathore et al.   MOLECULAR MICROBIOLOGY

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations

(2010) Matthew S. Kimber et al.   STRUCTURE

Fast Two-Dimensional NMR Spectroscopy of High Molecular Weight Protein Assemblies

(2009) Carlos Amero et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Structural Basis for the Activation and Peptide Recognition of Bacterial ClpP

(2008) Dong Young Kim et al.   JOURNAL OF MOLECULAR BIOLOGY