mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes

Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals

(2018) Shira Anzi et al.   DEVELOPMENTAL CELL

Transgene-associated hGH expression in pancreatic β-cells impairs identification of sex-based gene expression differences

(2018) Jennifer S Stancill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

(2017) Gia Cac Chau et al.   JOURNAL OF CELL BIOLOGY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Raptor regulates functional maturation of murine beta cells

(2017) Qicheng Ni et al.   Nature Communications

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

(2017) Manuel Blandino-Rosano et al.   Nature Communications

Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development

(2017) Lynda Elghazi et al.   Molecular Metabolism

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene

(2017) Timothy J. Pullen et al.   Frontiers in Genetics

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(2016) Arash Yavari et al.   Cell Metabolism

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Disallowance ofAcot7in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion

(2016) Aida Martinez-Sanchez et al.   DIABETES

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

(2016) Ting Yuan et al.   DIABETOLOGIA

TSC1-mTOR signaling determines the differentiation of islet cells

(2016) Li Ding et al.   JOURNAL OF ENDOCRINOLOGY

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells

(2016) Avigail Dreazen Wittenberg et al.   PLoS One

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

(2015) Anna Maria D'Erchia et al.   MITOCHONDRION

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

(2015) Cécile Jacovetti et al.   Nature Communications

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise

(2014) Katarina Marcinko et al.   EXPERIMENTAL PHYSIOLOGY

LKB1 and AMPK differentially regulate pancreatic β-cell identity

(2014) Marina Kone et al.   FASEB JOURNAL

Maternal diet–induced microRNAs and mTOR underlie β cell dysfunction in offspring

(2014) Emilyn U. Alejandro et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

(2011) Jean-Claude Henquin   DIABETES RESEARCH AND CLINICAL PRACTICE

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo

(2010) Gao Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells

(2010) C. Aguayo-Mazzucato et al.   DIABETOLOGIA

Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

(2010) G. Sun et al.   DIABETOLOGIA

Critical roles for the TSC-mTOR pathway in β-cell function

(2009) Hiroyuki Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

(2009) Accalia Fu et al.   Cell Metabolism

mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

(2009) Norman Balcazar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers

(2008) Craig Dorrell et al.   Stem Cell Research