Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells

Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy

(2015) Jinxian Xu et al.   KIDNEY INTERNATIONAL

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

(2014) Zhe Chang et al.   PLoS One

Reassessment of the Role of TSC, mTORC1 and MicroRNAs in Amino Acids-Meditated Translational Control of TOP mRNAs

(2014) Ilona Patursky-Polischuk et al.   PLoS One

Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

(2014) S. O. Sulima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

(2014) Rachel Miloslavski et al.   Journal of Molecular Cell Biology

Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer

(2013) A. Khalaileh et al.   CANCER RESEARCH

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

mTORC1 Status Dictates Tumor Response to Targeted Therapeutics

(2013) I. Kelsey et al.   Science Signaling

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

LEDGF (p75) promotes DNA-end resection and homologous recombination

(2012) Mads Daugaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Decreased IRS Signaling Impairs  -Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in  -Cells

(2010) L. Elghazi et al.   DIABETES

CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer

(2010) S. Ripka et al.   GUT

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

(2009) Norman Balcazar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN regulate angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells

(2009) Jiachi Ma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

How Common Are Extraribosomal Functions of Ribosomal Proteins?

(2009) Jonathan R. Warner et al.   MOLECULAR CELL

Common corruption of the mTOR signaling network in human tumors

(2009) S Menon et al.   ONCOGENE

Mice Deficient in Ribosomal Protein S6 Phosphorylation Suffer from Muscle Weakness that Reflects a Growth Defect and Energy Deficit

(2009) Igor Ruvinsky et al.   PLoS One

AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

(2008) I. Plo et al.   CANCER RESEARCH

Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling

(2008) Lynda Elghazi et al.   GASTROENTEROLOGY

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

(2008) Samira Alliouachene et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA