PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

(2018) Ismail Syed et al.   Cell Metabolism

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice

(2018) Elsa Pflimlin et al.   Cell Metabolism

On the Complexity of PAHSA Research

(2018) Ondrej Kuda   Cell Metabolism

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects

(2018) Ismail Syed et al.   Cell Metabolism

Microfluidic-enabled quantitative measurements of insulin release dynamics from single islets of Langerhans in response to 5-palmitic acid hydroxy stearic acid

(2018) Basel Bandak et al.   LAB ON A CHIP

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity

(2017) Xinyun Bi et al.   JOURNAL OF CLINICAL INVESTIGATION

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation

(2017) Andrew T. Nelson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fish oil supplementation inhibits endoplasmic reticulum stress and improves insulin resistance: involvement of AMP-activated protein kinase

(2017) Wenqi Yang et al.   Food & Function

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

(2017) Archana Vijayakumar et al.   Cell Reports

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

(2016) Matthew J. Kolar et al.   BIOCHEMISTRY

NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model

(2016) Rajakrishnan Veluthakal et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties

(2016) Ondrej Kuda et al.   DIABETES

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

(2016) James A. Pearson et al.   JOURNAL OF AUTOIMMUNITY

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses

(2016) Jennifer Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

(2016) William H Parsons et al.   Nature Chemical Biology

A LC-MS–based workflow for measurement of branched fatty acid esters of hydroxy fatty acids

(2016) Tejia Zhang et al.   Nature Protocols

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

(2015) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

An in silico MS/MS library for automatic annotation of novel FAHFA lipids

(2015) Yan Ma et al.   Journal of Cheminformatics

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes

(2014) H Peter Chase et al.   PEDIATRIC DIABETES

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

(2014) Wenxian Fu et al.   eLife

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

(2012) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Omega-3 fatty acids and their lipid mediators: Towards an understanding of resolvin and protectin formation

(2012) Karsten H. Weylandt et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited

(2011) M. A. Atkinson et al.   DIABETES

Anti-CD3 antibodies for type 1 diabetes: beyond expectations

(2011) Jean-François Bach   LANCET

Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany

(2011) Stefan Ehehalt et al.   PEDIATRIC DIABETES

Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: The Diabetes Autoimmunity Study in the Young (DAISY)

(2011) Melissa R Miller et al.   PEDIATRIC DIABETES

Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction

(2010) Marta Michalska et al.   BIOSCIENCE REPORTS

Ductal Origin Hypothesis of Pancreatic Regeneration under Attack

(2010) Jake A. Kushner et al.   Cell Metabolism

Protein Farnesylation-Dependent Raf/Extracellular Signal-Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic  -Cells

(2010) A. Kowluru et al.   DIABETES

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

Cellular Production of n-3 PUFAs and Reduction of n-6-to-n-3 Ratios in the Pancreatic  -Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death

(2009) D. Wei et al.   DIABETES

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes

(2009) L. Vija et al.   DIABETES & METABOLISM

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

The MAPK Kinase Kinase-1 Is Essential for Stress-Induced Pancreatic Islet Cell Death

(2008) Dariush Mokhtari et al.   ENDOCRINOLOGY

Exendin-4 Modulates Diabetes Onset in Nonobese Diabetic Mice

(2007) Irene Hadjiyanni et al.   ENDOCRINOLOGY