The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

Cytokine-mediated β-cell damage in PARP-1-deficient islets

(2012) Teresa Andreone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic  -Cells

(2012) V. Varanasi et al.   DIABETES

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

(2012) D. A. Cunha et al.   DIABETES

Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase

(2012) C. C. Patterson et al.   DIABETOLOGIA

Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines

(2012) Yaíma L. Lightfoot et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice

(2012) Maria C. Seleme et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications

(2011) Mohd Khan et al.   BMC IMMUNOLOGY

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

(2011) T. C. Thayer et al.   DIABETES

Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes

(2011) Helen E. Thomas et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide

(2011) Katherine J. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells

(2011) Olga Efimova et al.   PLoS One

Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment

(2011) Hyemi Lee et al.   PLoS One

Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5

(2011) Yaíma L. Lightfoot et al.   PLoS One

Pancreatic β-Cell Death in Response to Pro-Inflammatory Cytokines Is Distinct from Genuine Apoptosis

(2011) J. Jason Collier et al.   PLoS One

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

(2010) Li Qiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity

(2010) H. M. Tse et al.   JOURNAL OF IMMUNOLOGY

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

(2010) Marina D. Kraaij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

(2010) Grace Y. Lam et al.   Seminars in Immunopathology

Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage

(2009) Katherine J. Hughes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of Increased ROS Dissipation in Prevention of T1D

(2009) Jing Chen et al.   Annals of the New York Academy of Sciences

Mitochondria mediated cell death in diabetes

(2009) Gyorgy Szabadkai et al.   APOPTOSIS

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

(2009) J. D. Matute et al.   BLOOD

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

(2009) F. S. Wong et al.   DIABETES

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

(2009) M. D. McKenzie et al.   DIABETES

Repair of Nitric Oxide-damaged DNA in β-Cells Requires JNK-dependent GADD45α Expression

(2009) Katherine J. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Attenuates Nitric Oxide-induced β-Cell Death

(2009) Gordon P. Meares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

(2009) P. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

IL-1β caused pancreatic β-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway

(2009) Q. Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of hydroxyl radical modified GAD65: A potential autoantigen in type 1 diabetes

(2008) Mohd Wajid A. Khan et al.   AUTOIMMUNITY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine-Induced  -Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

(2008) M. C. Akerfeldt et al.   DIABETES

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Redox modulation inhibits CD8 T cell effector function

(2008) Martha M. Sklavos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant therapy in multiple sclerosis

(2008) Abbas Mirshafiey et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Concordance for Islet Autoimmunity among Monozygotic Twins

(2008) Maria J. Redondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress in ulcerative colitis-associated carcinogenesis

(2008) A. Roessner et al.   PATHOLOGY RESEARCH AND PRACTICE

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

(2008) Volkert A. L. Huurman et al.   PLoS One