Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

(2019) Jun Wang et al.   NATURE MEDICINE

CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen

(2019) Shiteng Duan et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis

(2019) Kyle J. Bednar et al.   ACS Chemical Biology

Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

(2019) Quentin Haas et al.   Cancer Immunology Research

The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival

(2019) Eillen Tecle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

(2019) Kunio Kawanishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialic acid blockade suppresses tumor growth by enhancing T cell-mediated tumor immunity

(2018) Christian Büll et al.   CANCER RESEARCH

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

(2018) Jeremy A. O'Sullivan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

(2018) Esther Bandala-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-based glycan arrays for probing glycan–glycan binding protein interactions

(2018) Jennie Grace Briard et al.   Nature Communications

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells

(2018) Jerry J. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec expression on the surface of human, bull and ram sperm

(2018) K Alkhodair et al.   REPRODUCTION

Evolution of the exclusively human pathogen Neisseria gonorrhoeae : Human-specific engagement of immunoregulatory Siglecs

(2018) Corinna S. Landig et al.   Evolutionary Applications

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

(2018) Lenneke A.M. Cornelissen et al.   INTERNATIONAL JOURNAL OF CANCER

B Cell Siglecs–News on Signaling and Its Interplay With Ligand Binding

(2018) Sarah J. Meyer et al.   Frontiers in Immunology

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

(2018) Joyce Lübbers et al.   Frontiers in Immunology

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

(2018) Takashi Angata   Frontiers in Immunology

Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer

(2017) Olivia Joan Adams et al.   GLYCOBIOLOGY

Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties

(2017) Huifeng Yu et al.   GLYCOBIOLOGY

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model

(2017) Kyle J. Bednar et al.   JOURNAL OF IMMUNOLOGY

Molecular basis of human CD22 function and therapeutic targeting

(2017) June Ereño-Orbea et al.   Nature Communications

Sialic Acids in the Immune Response during Sepsis

(2017) Yan-Cun Liu et al.   Frontiers in Immunology

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

(2017) Gitanjali Dharmadhikari et al.   Scientific Reports

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

(2016) Robert P. Schleimer et al.   Current Opinion in Allergy and Clinical Immunology

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation

(2016) Yuanyuan Ding et al.   NATURE IMMUNOLOGY

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

(2016) Richard Beatson et al.   NATURE IMMUNOLOGY

Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8

(2016) Johannes M. Pröpster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

(2016) Maurizio Perdicchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence ofSIGLEC9polymorphisms on COPD phenotypes including exacerbation frequency

(2016) Takeo Ishii et al.   RESPIROLOGY

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

(2016) Maurizio Perdicchio et al.   Oncotarget

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14

(2015) J. J. Fong et al.   EMBO JOURNAL

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

(2015) Bruce S. Bochner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice

(2015) Jennifer Müller et al.   JOURNAL OF IMMUNOLOGY

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

(2015) Ismael Secundino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

(2015) Shaun Spence et al.   Science Translational Medicine

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches

(2015) Takashi Angata et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sialosignaling: Sialyltransferases as engines of self-fueling loops in cancer progression

(2014) Fabio Dall'Olio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense

(2014) Kayluz Frias Boligan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The interplay between Siglecs and sialylated pathogens

(2014) Y.-C. Chang et al.   GLYCOBIOLOGY

CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance

(2014) L. Nitschke   GLYCOBIOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Siglecs Induce Tolerance to Cell Surface Antigens by BIM-Dependent Deletion of the Antigen-Reactive B Cells

(2014) Matthew S. Macauley et al.   JOURNAL OF IMMUNOLOGY

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A red meat-derived glycan promotes inflammation and cancer progression

(2014) Annie N. Samraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Exploration of Sialic Acid Diversity and Biology Using Sialoglycan Microarrays

(2013) Lingquan Deng et al.   BIOPOLYMERS

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

(2013) Vered Padler-Karavani et al.   FASEB JOURNAL

Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

(2013) Yusuke Kameda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22

(2013) F. Pfrengle et al.   JOURNAL OF IMMUNOLOGY

Sialyltransferase ST3Gal-III Regulates Siglec-F Ligand Formation and Eosinophilic Lung Inflammation in Mice

(2013) M. Suzukawa et al.   JOURNAL OF IMMUNOLOGY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

(2013) Esther Bandala-Sanchez et al.   NATURE IMMUNOLOGY

Dendritic Cells: A Spot on Sialic Acid

(2013) Hélio J. Crespo et al.   Frontiers in Immunology

Click and Pick: Identification of Sialoside Analogues for Siglec-Based Cell Targeting

(2012) Cory D. Rillahan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells

(2012) Paula C. Soto et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sialoadhesin in recognition of self and non-self

(2012) Mariliis Klaas et al.   Seminars in Immunopathology

Leukocyte Inflammatory Responses Provoked by Pneumococcal Sialidase

(2012) Y.-C. Chang et al.   mBio

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer

(2011) K. Aalto et al.   BLOOD

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas

(2011) Nivedita Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antigen Targeting to Plasmacytoid Dendritic Cells via Siglec-H Inhibits Th Cell-Dependent Autoimmunity

(2011) J. Loschko et al.   JOURNAL OF IMMUNOLOGY

Siglec-F Inhibition Reduces Esophageal Eosinophilia and Angiogenesis in a Mouse Model of Eosinophilic Esophagitis

(2011) Eitan Rubinstein et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells

(2010) Y. Kawasaki et al.   GLYCOBIOLOGY

A Novel Function of Siglec-9 A391C Polymorphism on T Cell Receptor Signaling

(2010) Kyung Ah Cheong et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

In Situ transLigands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics

(2010) T. N. C. Ramya et al.   MOLECULAR & CELLULAR PROTEOMICS

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

(2010) Ira Surolia et al.   NATURE

Uniquely human evolution of sialic acid genetics and biology

(2010) A. Varki   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model

(2009) Dae Jin Song et al.   CLINICAL IMMUNOLOGY

Deletion polymorphism of SIGLEC14 and its functional implications

(2009) M. Yamanaka et al.   GLYCOBIOLOGY

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

(2009) Bao Hoa Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling

(2009) D. J. Song et al.   JOURNAL OF IMMUNOLOGY

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

SIGLEC16encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpartSIGLEC11and has functional and non-functional alleles in humans

(2008) Huan Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY