Article
Multidisciplinary Sciences
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L. Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B. -H. Tok, James C. Y. Dunn, Bianxiao Cui, Sergiu P. Pasca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Summary: Neurotransmitters play crucial roles in regulating neural circuit dynamics in the central and peripheral nervous systems, including the gastrointestinal tract. However, there is a lack of bioelectronic tools for real-time monitoring of neurotransmitter dynamics in vivo, especially in the enteric nervous system. In this study, the researchers developed a tissue-mimicking, stretchable neurochemical biological interface called NeuroString, which allows chronic in vivo real-time monitoring of monoamine levels in the brain and serotonin dynamics in the gut. This interface has the potential for studying the impact of neurotransmitters on gut microbes and brain-gut communication.
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Neurosciences
Lola Welsch, Esther Colantonio, Mathilde Frison, Desiree A. Johnson, Shannan P. Mcclain, Victor Mathis, Matthew R. Banghart, Sami Ben Hamida, Emmanuel Darcq, Brigitte L. Kieffer
Summary: This study found that μ opioid receptor neurons in the dorsal raphe nucleus (DRN) participate in reward and emotional responses. These neurons respond to rewarding stimuli and their optoactivation has reinforcing effects and promotes positive emotional responses. Furthermore, their effects are partially mediated by their projections to the lateral hypothalamus.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Chemistry, Analytical
Juan Qiao, Deyu Wu, Yuying Song, Wenliang Ji, Qingwei Yue, Lanqun Mao, Li Qi
Summary: A new fluorescent probe was designed to simultaneously measure intracellular temperature and norepinephrine (NE) variations, revealing an increase in cell temperature and decrease in NE reuptake during antidepressant drug inhibition. This study provides insight into the underlying mechanisms of neurotransmitter signaling pathways, which could aid in the treatment of depression.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Christopher Patzke, Jinye Dai, Marisa M. Brockmann, Zijun Sun, Pascal Fenske, Christian Rosenmund, Thomas C. Sudhof
Summary: Cannabis and cannabinoid drugs play a central role in modulating neurotransmitter release in neurons by stimulating CB1 receptors and affecting the size of synaptic vesicle pools. Synapsin-1 is identified as a key factor in the CB1R-dependent regulation of neurotransmission.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Shiyu Wang, Anna I. Neel, Kristen L. Adams, Haiguo Sun, Sara R. Jones, Allyn C. Howlett, Rong Chen
Summary: It has been found that long-term use of atorvastatin reduces the function of dopamine transporter (DAT) in neuroblastoma 2A cells, possibly due to the drug lowering brain cholesterol levels. However, atorvastatin does not have a significant effect on dopamine efflux. This study has important implications for understanding the neurological side effects associated with BBB penetrant statins.
Article
Psychology, Biological
Reza Shadmehr, Alaa A. Ahmed
Summary: The brain assigns value to things and controls our movements through shared neural circuits. Damage to reward signaling systems like dopamine and serotonin can affect mood, decision-making patterns, and movement. The way we move reveals how much we value what we are moving towards.
BEHAVIORAL AND BRAIN SCIENCES
(2021)
Article
Polymer Science
Rania Djermane, Celia Nieto, Julio C. Vargas, Milena Vega, Eva M. Martin del Valle
Summary: In the past decade, novel strategies for synthesizing polydopamine nanoparticles (PDA NPs) have been developed due to their applications in nanotechnology. This study focused on analyzing the formation kinetics of PDA NPs and proposed a mathematical model to predict PDA NP diameter. Additionally, it was shown that reducing the synthesis time of PDA NPs from 24 to 3 hours did not alter their key properties, making them a relevant material for nanomedicine studies.
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Baojie Shen, Xiaoyu Yang, Sarah Elizabeth Noll, Xiaojie Yang, Yanping Liu, Shanshan Jia, Jiaxing Zhao, Shi Zheng, Richard N. Zare, Hongying Zhong
Summary: A cell-based ambient Venturi autosampling device was developed for real-time monitoring of dynamic cell secretions in response to chemical stimulations. It utilizes the Venturi effect to deliver secretory products of cells for detection and screening using matrix assisted laser desorption ionization mass spectrometry.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kishore K. Joshi, Tarmie L. Matlack, Stephanie Pyonteck, Mehul Vora, Ralph Menzel, Christopher Rongo
Summary: Metazoans utilize protein homeostasis pathways to respond to adverse conditions, with the nervous system playing a role in regulating proteostasis in different tissues. This study reveals that Caenorhabditis elegans uses biogenic amine neurotransmitters to modulate UPS proteostasis in epithelia by promoting eicosanoid production through P450 monooxygenases, ultimately maintaining protein turnover.
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Paul J. Fletcher, Zhaoxia Li, Xiaodong Ji, Guy A. Higgins, Douglas Funk
Summary: This study examined the effects of manipulating serotonin receptors on alcohol self-administration and alcohol-seeking behavior in rats. The results showed that blocking 5-HT2A receptors had limited effects on reducing alcohol-seeking, while activating 5-HT2C receptors had a broader range of effects on reducing alcohol self-administration, alcohol drinking, and alcohol-seeking behavior.
Article
Psychiatry
Stina Borchers, Jil Carl, Katharina Schormair, Jean-Philippe Krieger, Mohammed Asker, Christian E. Edvardsson, Elisabeth Jerlhag, Karolina P. Skibicka
Summary: Studies show that contrary to the common notion that female rats are not aggressive, female rats also exhibit aggressive behavior outside of maternal context and find winning in aggressive interactions rewarding. This reward is similar to that experienced by male rats and is dopamine-dependent.
TRANSLATIONAL PSYCHIATRY
(2023)
Editorial Material
Biochemical Research Methods
B. Jill Venton, Rebecca R. Pompano
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuanyu Chang, B. Jill Venton
Summary: Rapid adenosine signaling in the brain provides local neuromodulation but is limited in spatial resolution and regional coordination. This study used dual-channel fast-scan cyclic voltammetry to measure adenosine release in mouse brain slices, revealing localized spontaneous adenosine events and regionally extended adenosine release after mechanical stimulation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Qizhang Jia, Cheng Yang, B. Jill Venton, Kateri H. DuBay
Summary: This study utilizes molecular dynamics simulations to investigate the surface diffusion of dopamine on graphene. The findings suggest that dopamine rapidly adsorbs to the surface and diffuses quickly, with its vertical placement influenced by charge.
Article
Chemistry, Physical
Qun Cao, Zijun Shao, Dale Hensley, B. Jill Venton
Summary: This study mass fabricates carbon nanoelectrodes by growing carbon nanospikes (CNSs) on metal wires, which have remarkable electrochemical properties and can be mass fabricated on almost any substrate without using catalysts. The CNS nanoelectrodes show excellent sensitivity for the detection of neurotransmitters like dopamine using fast-scan cyclic voltammetry.
FARADAY DISCUSSIONS
(2022)
Article
Electrochemistry
Zijun Shao, B. Jill Venton
Summary: Carbon nanotube yarn microelectrodes (CNTYMEs) exhibit different trapping effects on anions and cations, and secondary peaks can be used for dopamine identification in mixtures.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Editorial Material
Chemistry, Physical
Jordi Cabana, Thomas Alaan, George W. Crabtree, Marta C. Hatzell, Karthish Manthiram, Daniel A. Steingart, Iryna Zenyuk, Feng Jiao, Aleksandra Vojvodic, Jenny Y. Yang, Nitash P. Balsara, Kristin A. Persson, Donald J. Siegel, Christy L. Haynes, Janine Mauzeroll, Mei Shen, B. Jill Venton, Nina Balke, Joaquin Rodriguez-Lopez, Debra R. Rolison, Reza Shahbazian-Yassar, Venkat Srinivasan, Santanu Chaudhuri, Adrien Couet, Jason Hattrick-Simpers
ACS ENERGY LETTERS
(2022)
Article
Biochemical Research Methods
Scott T. Lee, Yuanyu Chang, B. Jill Venton
Summary: This study investigated the role of pannexin channels, specifically pannexinl (Panx1) channels, in rapid adenosine release. The results showed that Panx1 is a release mechanism for mechanically stimulated adenosine release, but not the only mechanism.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Zijun Shao, Yuanyu Chang, B. Jill Venton
Summary: Carbon electrodes are widely used in neurotransmitter detection due to their good electrochemical properties, high biocompatibility, and inert chemistry. Customizing the shape and nanostructuring the surface of carbon electrodes enhance their electrochemical properties, including sensitivity, selectivity, and secondary peaks. This enables new applications in neuroscience, such as distinguishing different catecholamines, detecting vesicular release in single cells, and multi-region measurements in vivo.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Kelly E. Dunham, B. Jill Venton
Summary: This study provides a detailed investigation into the effects of selective serotonin reuptake inhibitors (SSRIs) on serotonin concentration and reuptake in fruit fly larvae. The results show that different types of SSRIs have varying effects on serotonin concentration and reuptake in this model, which is valuable for future studies exploring the pharmacological effects of SSRIs with different genetic mutations in fruit flies.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qizhang Jia, B. Jill Venton, Kateri H. DuBay
Summary: This study investigates the adsorption and surface diffusion dynamics of dopamine on carbon nanotubes (CNTs) using molecular dynamics simulations. The results show that solvent affects the diffusion of adsorbates on solvated CNT surfaces, while curvature changes have minimal impact on diffusion. Furthermore, dopamine diffuses into the groove between aligned CNTs, enhancing its diffusion along the CNT axis.
Article
Chemistry, Multidisciplinary
Mimi Shin, B. Jill Venton
Summary: In this study, we developed fast-scan cyclic voltammetry (FSCV) to measure dopamine release in fruit flies during behavior. The results showed that sugar feeding induced longer dopamine release compared to acetylcholine stimulation in the mushroom body. In addition, administering dopamine transporter inhibitor or D2 receptor antagonist significantly increased sugar-evoked dopamine release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
B. Jill Venton, Zijun Shao, Leslie Wilson, Yuanyu Chang
Summary: Nanodiamonds (NDs) are a promising material for electrochemical sensing due to their large surface area, defect sites, and functional groups. Growing thin films of ND on niobium wires and oxygen plasma etching can increase sensitivity but slightly decrease fouling resistance.
Article
Biochemistry & Molecular Biology
Eduard Dumitrescu, Jeffrey M. Copeland, B. Jill Venton
Summary: This study investigates the effect of parkin knockdown on dopamine release in Drosophila. The results show that parkin knockdown causes age-dependent reduction of dopamine release in certain brain regions, leading to impaired locomotion. The findings provide insights into the mechanism of Parkinson's disease and suggest Drosophila as a useful model for studying dopamine functionality and potential therapies.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Chemistry, Physical
Yuanyu Chang, Qun Cao, B. Jill Venton
Summary: Traditional carbon electrodes made of glassy carbon or carbon fibers have limited shapes. 3D printing enables complete customization of shape and simultaneous fabrication of devices and electrodes. Additive manufacturing, the most common 3D printing method, involves adding carbon materials to make it conductive and applying treatments to enhance electrochemical activity. Another newer form, 2-photon lithography uses laser lithography to print electrodes in photoresist and then annealed to carbon. Applications of 3D printed carbon electrodes include nanoelectrode measurements, biosensor arrays, and integrated electrodes in microfluidic devices.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Biochemical Research Methods
He Zhao, Kailash Shrestha, Dale K. Hensley, B. Jill Venton
Summary: Carbon nanospikes (CNSs) are a new nanomaterial that enhances the sensitivity for dopamine detection. In this study, CNS-modified electrodes (CNSMEs) were evaluated for the detection of adenosine, hydrogen peroxide ( H2O2), and histamine. The results showed that CNSMEs had higher signals compared to conventional electrodes (CFMEs), with increased sensitivity for adenosine (4.8 times), H2O2 (1.5 times), and histamine (2 times). CNSMEs also promoted the formation of secondary products for adenosine and histamine, allowing differentiation from analytes with similar oxidation potentials. CNSs selectively enhanced the sensitivity for adenosine and histamine compared to H2O2. The use of CNSMEs in brain slices and tissue measurements showed high selectivity and low fouling.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)