The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival

(2018) Divya A. Verghese et al.   JOURNAL OF IMMUNOLOGY

Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis

(2018) Anja Thorenz et al.   KIDNEY INTERNATIONAL

Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2

(2018) Christian M. Karsten et al.   Frontiers in Immunology

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury

(2017) Felix Poppelaars et al.   FASEB JOURNAL

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse

(2017) Christian M. Karsten et al.   JOURNAL OF IMMUNOLOGY

The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury

(2017) Patrick J.C. Biggins et al.   JOURNAL OF NEUROTRAUMA

New concepts on the therapeutic control of complement anaphylatoxin receptors

(2017) Owen A. Hawksworth et al.   MOLECULAR IMMUNOLOGY

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

GPCRdb in 2018: adding GPCR structure models and ligands

(2017) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

(2017) Anna Kovtun et al.   Scientific Reports

Corrigendum to “The Controversial C5a Receptor C5aR2: Its Role in Health and Disease”

(2017) Ting Zhang et al.   Journal of Immunology Research

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

(2017) Natalie E. Stevens et al.   Scientific Reports

More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation

(2016) George Hajishengallis et al.   IMMUNOLOGICAL REVIEWS

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

(2016) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro

(2016) Miriam Kalbitz et al.   JOURNAL OF IMMUNOLOGY

Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes

(2016) Mikel D. Haggadone et al.   MEDIATORS OF INFLAMMATION

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

(2016) Michelle L. Halls et al.   Science Signaling

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

(2016) Michelle L. Halls et al.   Science Signaling

Differential Interaction of the Staphylococcal Toxins Panton–Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors

(2015) András N. Spaan et al.   JOURNAL OF IMMUNOLOGY

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production

(2015) Priyanka Pundir et al.   JOURNAL OF IMMUNOLOGY

High Expression of C5L2 Correlates with High Proinflammatory Cytokine Expression in Advanced Human Atherosclerotic Plaques

(2014) Santosh Vijayan et al.   AMERICAN JOURNAL OF PATHOLOGY

C5L2 is required for C5a-triggered receptor internalization and ERK signaling

(2014) Wei-Chan Hsu et al.   CELLULAR SIGNALLING

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a

(2014) Reena Halai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expression and regulation of complement receptors by human natural killer cells

(2014) Xiaoyun Min et al.   IMMUNOBIOLOGY

C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β-arrestin recruitment

(2014) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors

(2014) András N. Spaan et al.   Nature Communications

The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors

(2013) András N. Spaan et al.   Cell Host & Microbe

The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation

(2013) Markus Bosmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2

(2013) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis

(2013) R. Wang et al.   JOURNAL OF IMMUNOLOGY

Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology

(2013) Maria I Fonseca et al.   Journal of Neuroinflammation

Deficiency of C5L2 Increases Macrophage Infiltration and Alters Adipose Tissue Function in Mice

(2013) Danny Gauvreau et al.   PLoS One

A Pro-Inflammatory Role of C5L2 in C5a-Primed Neutrophils for ANCA-Induced Activation

(2013) Jian Hao et al.   PLoS One

IL-17 cytokines in immunity and inflammation

(2013) Wei Jin et al.   Emerging Microbes & Infections

C5L2 and C5aR interaction in adipocytes and macrophages: Insights into adipoimmunology

(2012) Pegah Poursharifi et al.   CELLULAR SIGNALLING

C5L2: a controversial receptor of complement anaphylatoxin, C5a

(2012) Rui Li et al.   FASEB JOURNAL

C5L2 receptor disruption enhances the development of diet-induced insulin resistance in mice

(2012) Alexandre Fisette et al.   IMMUNOBIOLOGY

Crosstalk between Toll like receptors and C5a receptor in human monocyte derived DCs suppress inflammatory cytokine production

(2012) Anouk Zaal et al.   IMMUNOBIOLOGY

C5a Receptor-Dependent Cell Activation by Physiological Concentrations of Desarginated C5a: Insights from a Novel Label-Free Cellular Assay

(2012) E. S. Reis et al.   JOURNAL OF IMMUNOLOGY

Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney

(2012) Maaike B. van Werkhoven et al.   MOLECULAR IMMUNOLOGY

Sphingosine Kinase 1 Mediation of Expression of the Anaphylatoxin Receptor C5L2 Dampens the Inflammatory Response to Endotoxin

(2012) Kurt Bachmaier et al.   PLoS One

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2

(2011) Anne-Catherine Raby et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for C5L2 in the Pathogenesis of Experimental Allergic Asthma

(2010) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Complement component 5a (C5a)

(2009) Helga D. Manthey et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation

(2009) Wei Cui et al.   MOLECULAR IMMUNOLOGY

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2

(2008) Hyun Lee et al.   IMMUNOLOGY AND CELL BIOLOGY

The human complement fragment receptor, C5L2, is a recycling decoy receptor

(2008) Anne-Marie Scola et al.   MOLECULAR IMMUNOLOGY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE