Article
Multidisciplinary Sciences
Muhammad Irfan, Seung Chung
Summary: Tissue injury triggers an immune response and inflammation, and the complement system plays a role in the regeneration process. C5a receptor (C5aR) and C5a-like receptor 2 (C5AR2; C5L2) have been found to be involved in nerve sprouting and tissue formation. This study explores the role of C5L2 in regulating BDNF secretion in human dental pulp stem cells (DPSCs) and suggests its potential in accelerating nerve regeneration.
SCIENTIFIC REPORTS
(2023)
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Bocui Song, Qian Chen, Yuqi Li, Shuang Zhan, Rui Zhao, Xue Shen, Min Liu, Chunyu Tong
Summary: This review examines the progress of research into the role of exosomes in the pathogenesis, diagnosis, and treatment of allergic contact dermatitis (ACD). Exosomes affect the occurrence and development of ACD through immunoregulation among other ways, but further clarification is needed.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei Qiao, Dalong Zhi, Chen Yu, Chen Zhang, Kunyi Wu, Hui Fang, Shuai Shao, Wen Yin, Erle Dang, Ke Li, Gang Wang
Summary: Studies have shown that C3aR plays a protective role in psoriasis by negatively regulating the expression of K6, K16, and K17 in keratinocytes to inhibit cell proliferation and help reverse the progression of the disease.
Review
Immunology
Alessandra Zarantonello, Margot Revel, Anne Grunenwald, Lubka T. Roumenina
Summary: This article introduces the central effector molecule of the complement system, C3, and its various forms and fragments. It discusses the role of C3 in diseases and the process of C3 activation. The article also provides a detailed description of the interactions between C3a and opsonins with receptors, as well as the molecular architecture and functions of the receptors.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, Sebastiano Gangemi
Summary: IL-37 and IL-33 are newly identified cytokines that play a role in various inflammatory conditions. This review aims to collect and organize data from multiple studies to establish a comprehensive understanding of their role. The studies assessed mainly focused on atopic dermatitis and immunologic pathways. The collective data suggests a pro-inflammatory role for IL-33 and an anti-inflammatory role for IL-37, potentially linked in an IL-33/IL-37 axis. Early results indicate that both cytokines may serve as markers of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Holly Neale, Anna Cristina Garza-Mayers, Idy Tam, JiaDe Yu
Summary: ACD is a delayed hypersensitivity skin reaction to environmental allergens that affects children and adults similarly. However, pediatric patch testing for ACD is less common due to challenges such as smaller surface area for testing and difficulty in cooperation, particularly with younger children. Clinical suspicion guided by patient presentation and history is key in diagnosing ACD in children.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
Ichiro Takeuchi, Kumiko Yanagi, Shuji Takada, Toru Uchiyama, Arisa Igarashi, Kenichiro Motomura, Yuka Hayashi, Naoko Nagano, Ryo Matsuoka, Hiroki Sugiyama, Takako Yoshioka, Hirohisa Saito, Toshinao Kawai, Yumiko Miyaji, Yusuke Inuzuka, Yoichi Matsubara, Yukihiro Ohya, Toshiaki Shimizu, Kenji Matsumoto, Katsuhiro Arai, Ichiro Nomura, Tadashi Kaname, Hideaki Morita
Summary: A novel gain-of-function variant in the STAT6 gene has been identified in a patient with early-onset multiple allergic diseases. This variant leads to upregulation of STAT6 transcriptional activity and may be a potential cause of primary atopic disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Morgan Nguyen, Slaton Case, Nina Botto, Walter Liszewski
Summary: This study identified discussions about allergic contact dermatitis (ACD) across various social media platforms, including content created by patients, physicians, professional organizations, and companies. Instagram had the most content, while Facebook had patient support groups. However, YouTube videos presented poor quality medical information.
CONTACT DERMATITIS
(2022)
Review
Immunology
Philipp R. R. Esser, Michael Huber, Stefan F. F. Martin
Summary: Maintaining homeostasis is crucial for organismal health. The innate immune system and the unfolded protein response play important roles in inflammation and inflammatory diseases, including allergic contact dermatitis. This review explores the interplay between the innate immune system and cellular stress responses, focusing on the unfolded protein response.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jie Lin, Ya Xu, Peiwen Guo, Yu-Jie Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen
Summary: Due to metabolic disequilibrium and immune suppression, intracerebral hemorrhage patients are prone to infections. The intrinsic mechanisms underlying the effects of infection-related peripheral inflammation after ICH remain unclear.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Review
Biochemistry & Molecular Biology
Raffaele Brancaccio, Giuseppe Murdaca, Rossella Casella, Teresa Loverre, Laura Bonzano, Eustachio Nettis, Sebastiano Gangemi
Summary: Skin inflammation is a common feature of atopic dermatitis, allergic contact dermatitis and chronic spontaneous urticaria, and the pathogenetic mechanisms are not fully understood. This study reviews the role of miRNA in regulating inflammatory mechanisms and innate and adaptive immune responses in these skin conditions. miRNAs are found to be involved in the pathogenesis and regulation of atopic dermatitis, chronic spontaneous urticaria, and allergic contact dermatitis, and they could serve as biomarkers and potential therapeutic targets for these chronic skin conditions.
Article
Neurosciences
Wenliang Su, Jiawen Yu, Xiuhua Zhang, Lulu Ma, Yuguang Huang
Summary: Through proteomic analysis and immunohistochemical validation, this study revealed the upregulation of C3 protein in trigeminal satellite cells of ACD patients. The protein changes in ACD mainly focus on immune and peptidase activity, and the complement system may play a crucial role in forming pruritic and nociceptive sensations in ACD.
NEUROTOXICITY RESEARCH
(2021)
Review
Dermatology
Alix Danoy, Howard Maibach
Summary: The study found enantiospecificity in allergic reactions to certain chemicals, and proposed a link between one chemical and chronic actinic dermatitis. However, there was no clear evidence of enantio-stereospecificity in inducing allergic reactions. Future research combining modern analytical chemistry and new immunological knowledge is needed to gain clearer insights into the mechanism of allergens.