Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)

Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application

(2018) Dimitris Georgiadis et al.   CURRENT MEDICINAL CHEMISTRY

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1

(2018) Anastasia Mpakali et al.   MOLECULAR IMMUNOLOGY

Cell Surface MHC Class I Expression Is Limited by the Availability of Peptide-Receptive “Empty” Molecules Rather than by the Supply of Peptide Ligands

(2018) Liran Komov et al.   PROTEOMICS

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

(2018) José A. López de Castro   Frontiers in Immunology

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

(2017) Jennifer G. Abelin et al.   IMMUNITY

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome

(2017) Adrian Martín-Esteban et al.   JOURNAL OF AUTOIMMUNITY

The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing

(2017) Pablo Guasp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Leukocyte Antigen (HLA)-B27 Peptidomein Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion

(2017) Eilon Barnea et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

GibbsCluster: unsupervised clustering and alignment of peptide sequences

(2017) Massimo Andreatta et al.   NUCLEIC ACIDS RESEARCH

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules

(2016) Niranjana A. Nagarajan et al.   JOURNAL OF IMMUNOLOGY

Optimization and Structure–Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides

(2016) Paraskevi Kokkala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view

(2016) José A. López de Castro et al.   MOLECULAR IMMUNOLOGY

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis

(2015) Liye Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

ERAP1 Regulates Natural Killer Cell Function by Controlling the Engagement of Inhibitory Receptors

(2015) L. Cifaldi et al.   CANCER RESEARCH

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease

(2015) Michael J. Ombrello et al.   CURRENT OPINION IN RHEUMATOLOGY

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35-specific T-cell recognition

(2015) Martin Keller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune Cells

(2015) Yasser A. Aldhamen et al.   Journal of Innate Immunity

Pharmacogenomic agreement between two cancer cell line data sets

(2015) Nicolas Stransky et al.   NATURE

Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants

(2015) Robert Petryszak et al.   NUCLEIC ACIDS RESEARCH

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Immunogenicity of somatic mutations in human gastrointestinal cancers

(2015) E. Tran et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

(2015) Adrian Cortes et al.   Nature Communications

Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA-B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues

(2015) Alejandro Sanz-Bravo et al.   Arthritis & Rheumatology

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

(2014) Efstratios Stratikos   CURRENT OPINION IN CHEMICAL BIOLOGY

ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses

(2014) D. P. W. Rastall et al.   INTERNATIONAL IMMUNOLOGY

Functionally distinctERAP1allotype combinations distinguish individuals with Ankylosing Spondylitis

(2014) Emma Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of MHC-I Expression Is Prevalent but Reversible in Merkel Cell Carcinoma

(2014) K. G. Paulson et al.   Cancer Immunology Research

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines

(2014) Sebastian Boegel et al.   OncoImmunology

Modulating antigen processing for cancer immunotherapy

(2014) Efstratios Stratikos   OncoImmunology

A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition

(2014) Efstratios Stratikos et al.   Frontiers in Oncology

Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function

(2013) E. James et al.   JOURNAL OF IMMUNOLOGY

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies

(2013) Efstratios Stratikos et al.   MOLECULAR IMMUNOLOGY

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases

(2013) Carlos Alvarez-Navarro et al.   MOLECULAR IMMUNOLOGY

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

(2013) E. Zervoudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

Simultaneous alignment and clustering of peptide data using a Gibbs sampling approach

(2012) Massimo Andreatta et al.   BIOINFORMATICS

Peptidases trimming MHC class I ligands

(2012) Mirjana Weimershaus et al.   CURRENT OPINION IN IMMUNOLOGY

Nonclassical MHC class Ib–restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum

(2012) Niranjana A Nagarajan et al.   NATURE IMMUNOLOGY

Seq2Logo: a method for construction and visualization of amino acid binding motifs and sequence profiles including sequence weighting, pseudo counts and two-sided representation of amino acid enrichment and depletion

(2012) Martin Christen Frølund Thomsen et al.   NUCLEIC ACIDS RESEARCH

The role of classical and non-classical HLA class I antigens in human tumors

(2012) Juergen Bukur et al.   SEMINARS IN CANCER BIOLOGY

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

(2011) Efthalia Zervoudi et al.   BIOCHEMICAL JOURNAL

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

(2011) L. Cifaldi et al.   CANCER RESEARCH

NetMHCcons: a consensus method for the major histocompatibility complex class I predictions

(2011) Edita Karosiene et al.   IMMUNOGENETICS

Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ

(2011) Yoshikuni Goto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

(2011) Sungchul Kim et al.   NATURE IMMUNOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

A New Role for Zn(II) Aminopeptidases: Antigenic Peptide Generation and Destruction

(2009) Irini Evnouchidou et al.   CURRENT PHARMACEUTICAL DESIGN

Cellular Mechanisms that Edit the Immunopeptidome

(2009) Dimitra Georgiadou et al.   Current Proteomics

Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma

(2009) Akash M. Mehta et al.   GENES CHROMOSOMES & CANCER

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non‐lymphoid human tissues

(2008) Doriana Fruci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY