Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database

(2010) Paul C. D. Hawkins et al.   Journal of Chemical Information and Modeling

Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1

(2010) D. Georgiadou et al.   JOURNAL OF IMMUNOLOGY

Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

(2010) A. L. Albiston et al.   MOLECULAR PHARMACOLOGY

Endoplasmic reticulum aminopeptidases: biology and pathogenic potential

(2010) Nigil Haroon et al.   Nature Reviews Rheumatology

Cellular Mechanisms that Edit the Immunopeptidome

(2009) Dimitra Georgiadou et al.   Current Proteomics

Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors

(2009) Marcin Drag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1

(2008) Yoshikuni Goto et al.   BIOCHEMICAL JOURNAL

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One