ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses

Increased Frequency of EBV-Specific Effector Memory CD8+ T Cells Correlates with Higher Viral Load in Rheumatoid Arthritis

(2014) J. D. Lunemann et al.   JOURNAL OF IMMUNOLOGY

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies

(2013) Efstratios Stratikos et al.   MOLECULAR IMMUNOLOGY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response

(2013) Yasser A. Aldhamen et al.   PLoS One

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

(2012) Alessandra Fierabracci et al.   AUTOIMMUNITY REVIEWS

Characterization of Effector Memory CD8+ T Cells in the Synovial Fluid of Rheumatoid Arthritis

(2012) Bon-A Cho et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Vaccines Expressing the Innate Immune Modulator EAT-2 Elicit Potent Effector Memory T Lymphocyte Responses despite Pre-Existing Vaccine Immunity

(2012) Y. A. Aldhamen et al.   JOURNAL OF IMMUNOLOGY

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

(2012) Franca Rosa Guerini et al.   PLoS One

Autoreactive Effector/Memory CD4+ and CD8+ T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage

(2012) Ramiro Diz et al.   PLoS One

Post-proteasomal and proteasome-independent generation of MHC class I ligands

(2011) Peter van Endert   CELLULAR AND MOLECULAR LIFE SCIENCES

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Novel Susceptibility Loci for Kawasaki Disease in a Han Chinese Population by a Genome-Wide Association Study

(2011) Fuu-Jen Tsai et al.   PLoS One

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice

(2011) Sergey S. Seregin et al.   VACCINE

Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1

(2011) Amit Gandhi et al.   Scientific Reports

Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells

(2010) N. Blanchard et al.   JOURNAL OF IMMUNOLOGY

Expression of the SLAM Family of Receptors Adapter EAT-2 as a Novel Strategy for Enhancing Beneficial Immune Responses to Vaccine Antigens

(2010) Y. A. Aldhamen et al.   JOURNAL OF IMMUNOLOGY

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Association ofERAP1, but notIL23R, with ankylosing spondylitis in a Han Chinese population

(2009) Stuart I. Davidson et al.   ARTHRITIS AND RHEUMATISM

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

Proteases in MHC Class I Presentation and Cross-Presentation

(2009) Kenneth L. Rock et al.   JOURNAL OF IMMUNOLOGY

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Antigen-specific T-T interactions regulate CD4 T-cell expansion

(2008) J. Helft et al.   BLOOD

Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum

(2008) Nicolas Blanchard et al.   NATURE IMMUNOLOGY