Mechanisms of natural killer cell‐mediated cellular cytotoxicity

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

(2018) Amelia J. Brennan et al.   CELL DEATH AND DIFFERENTIATION

Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells

(2018) Marcus Lettau et al.   INTERNATIONAL IMMUNOLOGY

Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells

(2018) Katja Srpan et al.   JOURNAL OF CELL BIOLOGY

Single Degranulations in NK Cells Can Mediate Target Cell Killing

(2018) Lavesh A. Gwalani et al.   JOURNAL OF IMMUNOLOGY

Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells

(2018) Clarissa Liesche et al.   Frontiers in Immunology

Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin

(2017) Kelsey Lesteberg et al.   IMMUNOLOGIC RESEARCH

Granzyme K-deficient mice show no evidence of impaired antiviral immunity

(2017) Lars T Joeckel et al.   IMMUNOLOGY AND CELL BIOLOGY

Termination of the Activating NK Cell Immunological Synapse Is an Active and Regulated Process

(2017) Petra Netter et al.   JOURNAL OF IMMUNOLOGY

Real-time visualization of perforin nanopore assembly

(2017) Carl Leung et al.   Nature Nanotechnology

NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing

(2016) Hsiang-Ting Hsu et al.   JOURNAL OF CELL BIOLOGY

Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

(2016) Roxana Khazen et al.   Nature Communications

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

In vivopotential of recombinant granulysin against human tumors

(2015) Sameer Al-Wasaby et al.   OncoImmunology

Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity

(2014) Marie Meeths et al.   EXPERIMENTAL CELL RESEARCH

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

(2014) Emily M Mace et al.   IMMUNOLOGY AND CELL BIOLOGY

Real-Time Detection of CTL Function Reveals Distinct Patterns of Caspase Activation Mediated by Fas versus Granzyme B

(2014) Jinzhu Li et al.   JOURNAL OF IMMUNOLOGY

NK cells kill mycobacteria directly by releasing perforin and granulysin

(2014) Chia-Chen Lu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Classification of human natural killer cells based on migration behavior and cytotoxic response

(2013) B. Vanherberghen et al.   BLOOD

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

(2013) K. Krzewski et al.   BLOOD

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

(2013) A. Cohnen et al.   BLOOD

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

(2013) A. M. James et al.   BLOOD

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

(2013) J. A. Lopez et al.   BLOOD

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

(2013) O Susanto et al.   CELL DEATH AND DIFFERENTIATION

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

(2013) J. A. Lopez et al.   JOURNAL OF IMMUNOLOGY

Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells

(2013) P. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

(2013) F. Bertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controversies in granzyme biology

(2012) O. Susanto et al.   TISSUE ANTIGENS

Human and mouse granzyme M display divergent and species-specific substrate specificities

(2011) Stefanie A.H. de Poot et al.   BIOCHEMICAL JOURNAL

A quarter century of granzymes

(2011) C L Ewen et al.   CELL DEATH AND DIFFERENTIATION

Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes

(2011) Amelia J. Brennan et al.   IMMUNITY

Cytotoxic T lymphocyte perforin and Fas ligand working in concert even when Fas ligand lytic action is still not detectable

(2011) David Hassin et al.   IMMUNOLOGY

Two modes of lytic granule fusion during degranulation by natural killer cells

(2011) Dongfang Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

2B4 Engagement Mediates Rapid LFA-1 and Actin-Dependent NK Cell Adhesion to Tumor Cells as Measured by Single Cell Force Spectroscopy

(2011) S. C. Hoffmann et al.   JOURNAL OF IMMUNOLOGY

Effector Granules in Human T Lymphocytes: Proteomic Evidence for Two Distinct Species of Cytotoxic Effector Vesicles

(2011) Hendrik Schmidt et al.   JOURNAL OF PROTEOME RESEARCH

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Intracellular Serine Protease Inhibitor SERPINB4 Inhibits Granzyme M-Induced Cell Death

(2011) Pieter J. A. de Koning et al.   PLoS One

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

(2010) Špela Konjar et al.   IMMUNOLOGY

Rapid Lytic Granule Convergence to the MTOC in Natural Killer Cells Is Dependent on Dynein But Not Cytolytic Commitment

(2010) Ashley N. Mentlik et al.   MOLECULAR BIOLOGY OF THE CELL

Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH

(2010) Tilen Praper et al.   MOLECULAR IMMUNOLOGY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors

(2009) Y. T. Bryceson et al.   BLOOD

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1

(2009) P. Zhu et al.   BLOOD

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses

(2009) Dongfang Liu et al.   IMMUNITY

Biology and clinical relevance of granulysin

(2009) A. M. Krensky et al.   TISSUE ANTIGENS

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

(2008) V Romero et al.   CELL DEATH AND DIFFERENTIATION

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A

(2008) Niels Bovenschen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing

(2008) Sean P. Cullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

(2008) Yuming Guo et al.   MOLECULAR IMMUNOLOGY

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

(2008) F. C. Kurschus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells

(2008) Hendrik Schmidt et al.   PROTEOMICS