Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells

Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells

(2018) Alexandre F. Carisey et al.   CURRENT BIOLOGY

Single Degranulations in NK Cells Can Mediate Target Cell Killing

(2018) Lavesh A. Gwalani et al.   JOURNAL OF IMMUNOLOGY

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Termination of the Activating NK Cell Immunological Synapse Is an Active and Regulated Process

(2017) Petra Netter et al.   JOURNAL OF IMMUNOLOGY

NK Cell Exhaustion

(2017) Jiacheng Bi et al.   Frontiers in Immunology

Signaling and Polarized Communication Across the T Cell Immunological Synapse

(2016) Michael L. Dustin et al.   Annual Review of Cell and Developmental Biology

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

(2016) Stephan Halle et al.   IMMUNITY

NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing

(2016) Hsiang-Ting Hsu et al.   JOURNAL OF CELL BIOLOGY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Regulation of NKG2D Expression and Signaling by Endocytosis

(2016) Rosa Molfetta et al.   TRENDS IN IMMUNOLOGY

Sustained Immune Complex-Mediated Reduction in CD16 Expression after Vaccination Regulates NK Cell Function

(2016) Martin R. Goodier et al.   Frontiers in Immunology

CellTracker (not only) for dummies

(2015) Filippo Piccinini et al.   BIOINFORMATICS

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

(2015) Misty R. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells

(2015) Yawu Jing et al.   PLoS One

The immune synapse clears and excludes molecules above a size threshold

(2014) Adam N. R. Cartwright et al.   Nature Communications

Classification of human natural killer cells based on migration behavior and cytotoxic response

(2013) B. Vanherberghen et al.   BLOOD

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

Membrane-Type 6 Matrix Metalloproteinase Regulates the Activation-Induced Downmodulation of CD16 in Human Primary NK Cells

(2013) G. Peruzzi et al.   JOURNAL OF IMMUNOLOGY

Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells

(2013) P. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

(2011) Navin Varadarajan et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Imaging Immune Surveillance of Individual Natural Killer Cells Confined in Microwell Arrays

(2010) Karolin Guldevall et al.   PLoS One

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells

(2009) C. Cerboni et al.   BLOOD

Regulation of human NK-cell cytokine and chemokine production by target cell recognition

(2009) C. Fauriat et al.   BLOOD

Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration

(2009) Fiona J. Culley et al.   PLOS BIOLOGY

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Monoclonal Antibody Therapy for B-Cell Non-Hodgkin's Lymphoma

(2008) Bruce D. Cheson et al.   NEW ENGLAND JOURNAL OF MEDICINE