An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

(2011) Jane C Stinchcombe et al.   BMC BIOLOGY

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes

(2011) B. Qu et al.   JOURNAL OF IMMUNOLOGY

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy

(2011) Alice C. N. Brown et al.   PLOS BIOLOGY

The immunological synapse: a focal point for endocytosis and exocytosis

(2010) Gillian M. Griffiths et al.   JOURNAL OF CELL BIOLOGY

T Cell Polarity at the Immunological Synapse Is Required for CD154-Dependent IL-12 Secretion by Dendritic Cells

(2010) M. Tourret et al.   JOURNAL OF IMMUNOLOGY

Activation of the Ancestral Polarity Regulator Protein Kinase C  at the Immunological Synapse Drives Polarization of Th Cell Secretory Machinery toward APCs

(2010) F. Bertrand et al.   JOURNAL OF IMMUNOLOGY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation

(2008) Íris Caramalho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Shouts, whispers and the kiss of death: directional secretion in T cells

(2008) Morgan Huse et al.   NATURE IMMUNOLOGY