17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

(2018) Len Neckers et al.   CELL STRESS & CHAPERONES

Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells

(2018) Nicole Janssen et al.   CELLULAR IMMUNOLOGY

Combined BRAF and HSP90 inhibition in patients with unresectableBRAFV600E mutant melanoma

(2018) Zeynep Eroglu et al.   CLINICAL CANCER RESEARCH

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

(2018) Alireza Azimi et al.   Molecular Systems Biology

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

(2018) Toshiki Kijima et al.   Scientific Reports

Management of Metastatic Melanoma in 2018

(2018) Howard L. Kaufman et al.   JAMA Oncology

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells

(2018) Mariusz L. Hartman et al.   MOLECULAR CARCINOGENESIS

ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma

(2018) Rani Ojha et al.   Cancer Discovery

The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

(2018) Tania Morán Luengo et al.   TRENDS IN CELL BIOLOGY

A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R

(2017) Inés G. Muñoz et al.   FEBS LETTERS

IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling

(2017) Cheng Chen et al.   Journal of Translational Medicine

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells

(2017) Susanne Schaefer et al.   PLoS One

Phenotype-based variation as a biomarker of sensitivity to molecularly targeted therapy in melanoma

(2017) Kerem M. Senses et al.   MedChemComm

Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines

(2017) Bradley Garman et al.   Cell Reports

The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone

(2017) Karin Eigner et al.   Scientific Reports

The role of endoplasmic reticulum stress in neurodegenerative disease

(2016) Chunchen Xiang et al.   APOPTOSIS

HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer

(2016) Tarik Ghadban et al.   APOPTOSIS

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

(2016) Michaël Cerezo et al.   CANCER CELL

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations

(2016) Beata Talar et al.   PLoS One

Melanoma and the Unfolded Protein Response

(2016) Erin Sykes et al.   Cancers

Combined inhibition of Hsp90 and heme oxygenase-1 induces apoptosis and endoplasmic reticulum stress in melanoma

(2015) Ignazio Barbagallo et al.   ACTA HISTOCHEMICA

Membrane-bound heat shock proteins facilitate the uptake of dying cells and cross-presentation of cellular antigen

(2015) Haiyan Zhu et al.   APOPTOSIS

Synthesis and biological evaluation of geldanamycin analogs against human cancer cells

(2015) Yan-ping Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Heat-shock protein 90 inhibitors: will they ever succeed as chemotherapeutics?

(2015) Yao Wang et al.   Future Medicinal Chemistry

Pro-Survival Role of MITF in Melanoma

(2015) Mariusz L. Hartman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phenotypic diversity of patient-derived melanoma populations in stem cell medium

(2015) Malgorzata Sztiller-Sikorska et al.   LABORATORY INVESTIGATION

ABCB5 Maintains Melanoma-Initiating Cells through a Proinflammatory Cytokine Signaling Circuit

(2014) B. J. Wilson et al.   CANCER RESEARCH

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

ER Stress Response in Human Cellular Models of Senescence

(2014) Liliana Matos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Potential diagnostic significance of HSP90, ACS/TMS1, and L-plastin in the identification of melanoma

(2014) Allen G. Strickler et al.   MELANOMA RESEARCH

Evaluating Melanoma Drug Response and Therapeutic Escape with Quantitative Proteomics

(2014) Vito W. Rebecca et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of HSP90 by AT13387 Delays the Emergence of Resistance to BRAF Inhibitors and Overcomes Resistance to Dual BRAF and MEK Inhibition in Melanoma Models

(2014) T. Smyth et al.   MOLECULAR CANCER THERAPEUTICS

Natural Compounds' Activity against Cancer Stem-Like or Fast-Cycling Melanoma Cells

(2014) Malgorzata Sztiller-Sikorska et al.   PLoS One

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Anti-apoptotic proteins on guard of melanoma cell survival

(2013) Mariusz L. Hartman et al.   CANCER LETTERS

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress

(2013) Kwang Hong Tay et al.   CELLULAR SIGNALLING

Phenotypic Identification of the Redox Dye Methylene Blue as an Antagonist of Heat Shock Response Gene Expression in Metastatic Melanoma Cells

(2013) Angela Davis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oncogenic Activation of MEK/ERK Primes Melanoma Cells for Adaptation to Endoplasmic Reticulum Stress

(2013) Amanda Croft et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS-Mutant Melanoma

(2013) H. E. Haarberg et al.   MOLECULAR CANCER THERAPEUTICS

The Anti-Melanoma Activity of Dinaciclib, a Cyclin-Dependent Kinase Inhibitor, Is Dependent on p53 Signaling

(2013) Brijal M. Desai et al.   PLoS One

Vemurafenib Potently Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in BRAFV600E Melanoma Cells

(2013) D. Beck et al.   Science Signaling

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells

(2012) Che-Hsin Lee et al.   BIOCHIMIE

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters

(2012) Christopher Shipp et al.   CELL STRESS & CHAPERONES

The HSP90 Inhibitor XL888 Overcomes BRAF Inhibitor Resistance Mediated through Diverse Mechanisms

(2012) K. H. T. Paraiso et al.   CLINICAL CANCER RESEARCH

Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment

(2012) Malgorzata Sztiller-Sikorska et al.   MELANOMA RESEARCH

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones

(2011) David Siegel et al.   BIOCHEMICAL PHARMACOLOGY

The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations

(2011) G. Floris et al.   CLINICAL CANCER RESEARCH

Inducible Hsp70 in the Regulation of Cancer Cell Survival: Analysis of Chaperone Induction, Expression and Activity

(2011) Elisa Zorzi et al.   Cancers

Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs

(2010) Yuval Samuni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Geldanamycin and its anti-cancer activities

(2009) Yayoi Fukuyo et al.   CANCER LETTERS

Acquired Resistance to 17-Allylamino-17-Demethoxygeldanamycin (17-AAG, Tanespimycin) in Glioblastoma Cells

(2009) N. Gaspar et al.   CANCER RESEARCH

Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives

(2008) Y. Fukuyo et al.   CANCER RESEARCH