Inducible Hsp70 in the Regulation of Cancer Cell Survival: Analysis of Chaperone Induction, Expression and Activity

Drugging the heat shock factor 1 pathway: Exploitation of the critical cancer cell dependence on the guardian of the proteome

(2011) Emmanuel de Billy et al.   CELL CYCLE

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

(2011) Marissa V. Powers et al.   CELL CYCLE

KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia

(2011) Emel Sahin et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Cellules myéloïdes suppressives et cancer : une nouvelle cible thérapeutique

(2011) Fanny Chalmin et al.   M S-MEDECINE SCIENCES

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

(2011) Liliana Batista-Nascimento et al.   PLoS One

Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-α induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1

(2010) Yanhong Gao et al.   APOPTOSIS

N-Formyl-3,4-methylenedioxy-benzylidene-γ-butyrolaetam, KNK437 induces caspase-3 activation through inhibition of mTORC1 activity in Cos-1 cells

(2010) Hirofumi Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HSP70 and lysosomal storage disorders: novel therapeutic opportunities

(2010) Nikolaj H.T. Petersen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Whole genome analysis of p38 SAPK-mediated gene expression upon stress

(2010) Isabel Ferreiro et al.   BMC GENOMICS

Strap: A versatile transcription co-factor

(2010) Danmei Xu et al.   CELL CYCLE

Death by chaperone: HSP90, HSP70 or both?

(2010) Marissa V. Powers et al.   CELL CYCLE

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

(2010) Nikolaj H.T. Petersen et al.   CELL CYCLE

Regulation of the members of the mammalian heat shock factor family

(2010) Johanna K. Björk et al.   FEBS Journal

The p38 SAPK Is Recruited to Chromatin via Its Interaction with Transcription Factors

(2010) Isabel Ferreiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to thehsp70Promoter

(2010) Young Ju Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p27 Suppresses Arsenite-induced Hsp27/Hsp70 Expression through Inhibiting JNK2/c-Jun- and HSF-1-dependent Pathways

(2010) Jinyi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triptolide and TRAIL Combination Enhances Apoptosis in Cholangiocarcinoma

(2010) Kimberly A. Clawson et al.   JOURNAL OF SURGICAL RESEARCH

Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

(2010) E L Davenport et al.   LEUKEMIA

BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells

(2010) P. Rammer et al.   MOLECULAR CANCER THERAPEUTICS

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Combined effect of tumor necrosis factor (TNF)-α and heat shock protein (HSP)-70 in reducing apoptotic injury in hypoxia: A cell culture study

(2010) Gunjan Goel et al.   NEUROSCIENCE LETTERS

Protein Kinase A Binds and Activates Heat Shock Factor 1

(2010) Ayesha Murshid et al.   PLoS One

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

(2009) Longzhen Piao et al.   BMC CELL BIOLOGY

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70

(2009) A R Stankiewicz et al.   CELL DEATH AND DIFFERENTIATION

Multi-faceted role of HSP40 in cancer

(2009) Aparna Mitra et al.   CLINICAL & EXPERIMENTAL METASTASIS

Inhibiting the transcription factor HSF1 as an anticancer strategy

(2009) Luke Whitesell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hsp105β upregulates hsp70 gene expression through signal transducer and activator of transcription-3

(2009) Nobuyuki Yamagishi et al.   FEBS Journal

Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms

(2009) Vikas Dudeja et al.   GASTROENTEROLOGY

The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review

(2009) Stuart K. Calderwood et al.   GERONTOLOGY

Mesothelioma Cells Escape Heat Stress by Upregulating Hsp40/Hsp70 Expression via Mitogen-Activated Protein Kinases

(2009) Michael Roth et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

(2009) L. A. O'Reilly et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives

(2009) Rongsheng E. Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allostery in Hsp70 Chaperones Is Transduced by Subdomain Rotations

(2009) Akash Bhattacharya et al.   JOURNAL OF MOLECULAR BIOLOGY

Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells

(2009) Sabrina Fritah et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting HSP70 for Cancer Therapy

(2009) Lorenzo Galluzzi et al.   MOLECULAR CELL

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity

(2009) M Brunet Simioni et al.   ONCOGENE

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA polymerase II interacts with the Hspa1b promoter in mouse epididymal spermatozoa

(2009) Donald C Wilkerson et al.   REPRODUCTION

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

(2009) Mara B. Antonoff et al.   SURGERY

Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis

(2009) Yi-Chen Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Hsp90 molecular chaperone: an open and shut case for treatment

(2008) Laurence H. Pearl et al.   BIOCHEMICAL JOURNAL

Lysosomes and oxidative stress in aging and apoptosis

(2008) Tino Kurz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma

(2008) Ramadevi Nimmanapalli et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70

(2008) Prabir K. Chakraborty et al.   CANCER SCIENCE

Rapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 Loci

(2008) Steven J. Petesch et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

(2008) Mathias Gehrmann et al.   CELL STRESS & CHAPERONES

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

HSP70 and EndoG Modulate Cell Death by Heat in Human Skin Keratinocytes in vitro

(2008) Sathivel Chinnathambi et al.   CELLS TISSUES ORGANS

A transcription cofactor required for the heat-shock response

(2008) Danmei Xu et al.   EMBO REPORTS

Fusogenicity of membranes: The impact of acid sphingomyelinase on innate immune responses

(2008) Olaf Utermöhlen et al.   IMMUNOBIOLOGY

The Hsp90 Chaperone Machinery

(2008) Sebastian Karl Wandinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of HSP70 expression by the JNK kinases SEK1 and MKK7 in mouse embryonic stem cells treated with cadmium

(2008) Gen Nishitai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of HSP70 on ENPP1 expression and insulin-receptor activation

(2008) Antonella Marucci et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicity

(2008) Valérie Combaret et al.   Molecular Cancer

PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1

(2008) Hyun-Eui Kim et al.   MOLECULAR CELL

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

(2008) A. D. Steele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits

(2008) T. A. Sangster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of an imatinib-resistant K562 cell line highlights opposing roles of heat shock cognate 70 and heat shock 70 proteins in resistance

(2008) Marion Pocaly et al.   PROTEOMICS

Regulation of protein turnover by acetyltransferases and deacetylases

(2007) Karin Sadoul et al.   BIOCHIMIE

Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion

(2007) Olga Vasiljeva et al.   BIOCHIMIE