A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1)

(2017) Wolf-Dieter Lienhart et al.   FEBS Journal

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

(2017) Encarnación Medina-Carmona et al.   HUMAN MOLECULAR GENETICS

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

(2017) Encarnación Medina-Carmona et al.   Scientific Reports

On the link between conformational changes, ligand binding and heat capacity

(2016) S. Vega et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

(2016) Angel L. Pey et al.   CURRENT DRUG TARGETS

Recognition of enzymes lacking bound cofactor by protein quality control

(2016) Adrián Martínez-Limón et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

(2016) Encarnación Medina-Carmona et al.   Scientific Reports

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

(2014) Angel L. Pey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase1

(2014) Wolf-Dieter Lienhart et al.   FEBS Journal

Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria

(2014) Fredj ben Bdira et al.   HUMAN MOLECULAR GENETICS

The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis

(2013) B Lajin et al.   BRITISH JOURNAL OF CANCER

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells

(2010) Marco Garate et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

(2007) Marie A. Colucci et al.   ORGANIC & BIOMOLECULAR CHEMISTRY