Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
出版年份 2019 全文链接
标题
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Nature
发表日期
2019-02-13
DOI
10.1038/s41467-019-08554-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines
- (2018) Kyle Ellrott et al. Cell Systems
- Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
- (2018) Joshua Pan et al. Cell Systems
- Marked for death: targeting epigenetic changes in cancer
- (2017) Sophia Xiao Pfister et al. NATURE REVIEWS DRUG DISCOVERY
- Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
- (2017) Takao Fujisawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TumorFusions: an integrative resource for cancer-associated transcript fusions
- (2017) Xin Hu et al. NUCLEIC ACIDS RESEARCH
- A pathology atlas of the human cancer transcriptome
- (2017) Mathias Uhlen et al. SCIENCE
- Targeting Cancer Cells with BET Bromodomain Inhibitors
- (2017) Yali Xu et al. Cold Spring Harbor Perspectives in Medicine
- LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer
- (2016) Giorgio E. M. Melloni et al. BMC BIOINFORMATICS
- Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia
- (2016) Elena Ceccacci et al. BRITISH JOURNAL OF CANCER
- Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
- (2016) Laetitia J. Martin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
- (2016) Shaokun Shu et al. NATURE
- Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
- (2016) Anja F Hohmann et al. Nature Chemical Biology
- Targeting the cancer epigenome for therapy
- (2016) Peter A. Jones et al. NATURE REVIEWS GENETICS
- BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
- (2016) N. Tasdemir et al. Cancer Discovery
- The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
- (2016) Courtney Hodges et al. Cold Spring Harbor Perspectives in Medicine
- LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
- (2015) Peter G. K. Clark et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer
- (2015) Florian Gnad et al. BMC GENOMICS
- Chromatin signatures of cancer
- (2015) Marc A. Morgan et al. GENES & DEVELOPMENT
- 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain
- (2015) Sarah Picaud et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
- (2015) Natalie H. Theodoulou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drugging Chromatin in Cancer: Recent Advances and Novel Approaches
- (2015) Sheng F. Cai et al. MOLECULAR CELL
- Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
- (2015) Pawel K Mazur et al. NATURE MEDICINE
- Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
- (2015) Nicholas McGranahan et al. Science Translational Medicine
- Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains
- (2015) Duncan A. Hay et al. MedChemComm
- Pan-Cancer Analysis of Mutation Hotspots in Protein Domains
- (2015) Martin L. Miller et al. Cell Systems
- Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
- (2015) C. Kadoch et al. Science Advances
- PRADA: pipeline for RNA sequencing data analysis
- (2014) Wandaliz Torres-García et al. BIOINFORMATICS
- Vulnerabilities of Mutant SWI/SNF Complexes in Cancer
- (2014) Katherine C. Helming et al. CANCER CELL
- New and emerging HDAC inhibitors for cancer treatment
- (2014) Alison C. West et al. JOURNAL OF CLINICAL INVESTIGATION
- Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
- (2014) B. G. Wilson et al. MOLECULAR AND CELLULAR BIOLOGY
- The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
- (2014) Junwei Shi et al. MOLECULAR CELL
- Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
- (2014) Irfan A. Asangani et al. NATURE
- 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
- (2014) Eric Verdin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- RADIA: RNA and DNA Integrated Analysis for Somatic Mutation Detection
- (2014) Amie J. Radenbaugh et al. PLoS One
- An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma
- (2014) Maria Giuseppina Baratta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A rationale to target the SWI/SNF complex for cancer therapy
- (2014) Anja F. Hohmann et al. TRENDS IN GENETICS
- Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
- (2014) Lucie Guetzoyan et al. MedChemComm
- Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition
- (2014) R. Marmorstein et al. Cold Spring Harbor Perspectives in Biology
- Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
- (2014) E. Seto et al. Cold Spring Harbor Perspectives in Biology
- A global assessment of cancer genomic alterations in epigenetic mechanisms
- (2014) Muhammad A Shah et al. Epigenetics & Chromatin
- The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
- (2014) Robert Huether et al. Nature Communications
- Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
- (2013) Bjoern Chapuy et al. CANCER CELL
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Pan-cancer patterns of somatic copy number alteration
- (2013) Travis I Zack et al. NATURE GENETICS
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
- (2013) Alexandre Puissant et al. Cancer Discovery
- The mutational landscape of chromatin regulatory factors across 4,623 tumor samples
- (2013) Abel Gonzalez-Perez et al. GENOME BIOLOGY
- Absolute quantification of somatic DNA alterations in human cancer
- (2012) Scott L Carter et al. NATURE BIOTECHNOLOGY
- Epigenetic protein families: a new frontier for drug discovery
- (2012) Cheryl H. Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
- (2012) W. W. Lockwood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
- (2011) Johannes Zuber et al. NATURE
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- Targeting MYC dependence in cancer by inhibiting BET bromodomains
- (2011) J. A. Mertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
- (2011) Craig H Mermel et al. GENOME BIOLOGY
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started