Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

(2015) Peter G. K. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

(2015) Peiling Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain

(2015) Sarah Picaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

(2015) James Bennett et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

(2014) Martin Philpott et al.   Epigenetics & Chromatin

Tumor Suppressive Effects of Bromodomain-Containing Protein 7 (BRD7) in Epithelial Ovarian Carcinoma

(2013) Young-Ae Park et al.   CLINICAL CANCER RESEARCH

[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains

(2013) Oleg Fedorov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Efficient synthesis of indolizines and new imidazo[1,2-a]pyridines via the expected cyclization of aromatic cycloimmonium ylides with electron deficient alkynes and ethyl cyanoformate

(2013) C. Sandeep et al.   TETRAHEDRON LETTERS

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Prognostic relevance of BRD7 expression in colorectal carcinoma

(2012) Wen-Jing Wu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

No evidence for breast cancer susceptibility associated with variants of BRD7, a component of p53 and BRCA1 pathways

(2012) Judith Penkert et al.   Familial Cancer

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

(2012) Duncan Hay et al.   MedChemComm

The interactions between MicroRNA-200c and BRD7 in endometrial carcinoma

(2011) Young-Ae Park et al.   GYNECOLOGIC ONCOLOGY

Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery

(2011) Chun-wa Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

(2011) Martin Philpott et al.   Molecular BioSystems

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes

(2011) Sookil Tae et al.   NUCLEIC ACIDS RESEARCH

BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription

(2010) M. T. Harte et al.   CANCER RESEARCH

Gene regulation and tumor suppression by the bromodomain-containing protein BRD7

(2010) Fiamma Mantovani et al.   CELL CYCLE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

BRD7 is a candidate tumour suppressor gene required for p53 function

(2010) Jarno Drost et al.   NATURE CELL BIOLOGY

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

(2010) A. E. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New route synthesis of indolizines via 1,3-dipolar cycloaddition of pyridiniums and alkynes

(2009) Yongjia Shang et al.   TETRAHEDRON LETTERS

Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer

(2008) Ji Un Kang et al.   CANCER GENETICS AND CYTOGENETICS

BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells

(2008) Matthias D. Kaeser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY